INT140193

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Context Info
Confidence 0.71
First Reported 2001
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 58
Total Number 63
Disease Relevance 49.65
Pain Relevance 25.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp3) extracellular space (Mmp3) extracellular region (Mmp3)
proteinaceous extracellular matrix (Mmp3) nucleus (Mmp3) protein complex (Mmp3)
Anatomy Link Frequency
joint 7
fibroblasts 4
extracellular matrix 3
cartilage 3
macrophages 2
Mmp3 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 1779 100.00 Very High Very High Very High
metalloproteinase 1615 100.00 Very High Very High Very High
Inflammation 1007 100.00 Very High Very High Very High
chemokine 65 100.00 Very High Very High Very High
cytokine 597 99.72 Very High Very High Very High
Arthritis 1303 99.04 Very High Very High Very High
Osteoarthritis 137 98.60 Very High Very High Very High
COX2 1 98.52 Very High Very High Very High
Leflunomide 12 97.96 Very High Very High Very High
fibrosis 89 97.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 1784 100.00 Very High Very High Very High
INFLAMMATION 884 100.00 Very High Very High Very High
Aggression 21 100.00 Very High Very High Very High
Stomach Cancer 174 99.84 Very High Very High Very High
Atherosclerotic Plaque 11 99.84 Very High Very High Very High
Aneurism 190 99.68 Very High Very High Very High
Fibrosis 115 99.64 Very High Very High Very High
Cancer 1062 99.48 Very High Very High Very High
Arthritis 1366 99.04 Very High Very High Very High
Coronary Aneurysm 144 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In rodents, MMP-2, MMP-3, MMP-9, MMP-13, MMP-14, as well as TIMP-1 and TIMP-2 are expressed in early stages of HSC activation and have been implicated in fibrogenesis as well as fibrolysis (reviewed in [20]).
Gene_expression (expressed) of MMP-3 associated with fibrosis
1) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.89 Pain Relevance 0.31
Combined detection of both MMP-3 and CTXII on the other hand was more indicative for cartilage destruction.


Gene_expression (detection) of MMP-3 in cartilage associated with metalloproteinase
2) Confidence 0.61 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945063 Disease Relevance 0.24 Pain Relevance 0.37
This is in line with previous reports that demonstrated elevated MMP-3 expression levels in synovial fluids and sera of patients with rheumatoid arthritis as well as expression in joints of CIA rats [10-12].
Gene_expression (expression) of MMP-3 in joints associated with rheumatoid arthritis, metalloproteinase and arthritis
3) Confidence 0.61 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945063 Disease Relevance 1.26 Pain Relevance 0.74
The objective of our study was to determine whether the expression of Mmp-3, Mmp-13 and Ddr2 was increased in OA-like TM joints in mutant mice using immunohistochemistry.
Gene_expression (expression) of Mmp-3 in joints associated with osteoarthritis
4) Confidence 0.55 Published 2007 Journal Arch. Oral Biol. Section Abstract Doc Link 17125729 Disease Relevance 0.34 Pain Relevance 0.32
Mmp3 is typically expressed by macrophages within the atherosclerotic plaques found in coronary artery disease [28], and has been shown to promote plaque rupture, myocardial infarction and aneurysm [29].
Gene_expression (expressed) of Mmp3 in macrophages associated with atherosclerotic plaque, coronary artery disease, rupture, aneurism and myocardial infarction
5) Confidence 0.55 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481284 Disease Relevance 1.00 Pain Relevance 0.20
Although several studies have proposed MMP-3 as a useful indicator for inflammation in RA, the correlation of MMP-3 with joint destruction or its predictive value is still a matter of debate [10,13-18].
Spec (proposed) Gene_expression (proposed) of MMP-3 in joint associated with inflammation, rheumatoid arthritis and metalloproteinase
6) Confidence 0.46 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945063 Disease Relevance 1.35 Pain Relevance 0.82
When evaluating the value of serum markers, MMP-3 was found to be highly indicative of all the features of CIA, including inflammation, cartilage destruction and bone erosion.
Gene_expression (indicative) of MMP-3 in cartilage associated with inflammation, metalloproteinase and arthritis
7) Confidence 0.46 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945063 Disease Relevance 1.09 Pain Relevance 0.66
Although several studies have proposed MMP-3 as a useful indicator for inflammation in RA, the correlation of MMP-3 with joint destruction or its predictive value is still a matter of debate [10,13-18].
Gene_expression (proposed) of MMP-3 in joint associated with inflammation, rheumatoid arthritis and metalloproteinase
8) Confidence 0.46 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945063 Disease Relevance 1.33 Pain Relevance 0.78
We conclude that MMP-3 overexpression due to a proteolytic imbalance may lead to coronary aneurysm development through degradation of matrix components, especially lamina elastica.
Gene_expression (overexpression) of MMP-3 in lamina associated with coronary aneurysm
9) Confidence 0.46 Published 2004 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC526392 Disease Relevance 0.65 Pain Relevance 0.30
Others have reported that MMP-3 is expressed in atherosclerotic plaque cells, but not by cells in normal arteries [34-37].
Neg (not) Gene_expression (expressed) of MMP-3 in plaque associated with atherosclerotic plaque
10) Confidence 0.46 Published 2004 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC526392 Disease Relevance 0.93 Pain Relevance 0.10
Based on these and our own observations, we maintain that MMP-3 over-expression may occur in aneurysm segments.
Gene_expression (over) of MMP-3 associated with aneurism
11) Confidence 0.40 Published 2004 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC526392 Disease Relevance 0.94 Pain Relevance 0.16
Among a wide range of MMPs tested, only MMP-3 was over-expressed in the aortic aneurysm samples.
Gene_expression (-) of MMP-3 associated with metalloproteinase and aneurism
12) Confidence 0.40 Published 2004 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC526392 Disease Relevance 1.19 Pain Relevance 0.21
DMSO for 24 hours, before harvesting total RNA and determining expression of various MMP genes, including stromelysins 1 (MMP-3), 2 (MMP-10) and 3 (MMP-11), collagenases I (MMP-1) and IV (MMP-2) and meltrins ?
Spec (determining) Gene_expression (expression) of MMP-3
13) Confidence 0.39 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.08 Pain Relevance 0.04
Furthermore, immunohistochemical analysis indicated that the joint specimens from vehicle-treated CIA mice strongly stained for MMP-3, which is a key contributor to the destruction of cartilage, but treatment with LE and rLE reduced the expression of MMP-3 in inflammatory articular cartilage (Figure 2(b)).
Gene_expression (expression) of MMP-3 in joint associated with inflammation and arthritis
14) Confidence 0.39 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2841253 Disease Relevance 1.53 Pain Relevance 0.65
Increased levels of MMP-2, MMP-3, MMP-9 and MMP-12 have been identified in aneurysm vessel walls [23-27].
Gene_expression (levels) of MMP-3 associated with aneurism
15) Confidence 0.36 Published 2004 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC526392 Disease Relevance 0.72 Pain Relevance 0.26
We investigated the association between MMPs and coronary artery aneurysm by measuring the levels of MMP-1 and MMP-3 (both of which represent markers of proteolytic activity) in patients with coronary artery disease, some of whom had coronary aneurysms (cases) and others who did not (controls).


Gene_expression (levels) of MMP-3 in coronary artery associated with coronary artery disease, metalloproteinase, coronary aneurysm and aneurism
16) Confidence 0.36 Published 2004 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC526392 Disease Relevance 1.37 Pain Relevance 0.14
An increased propensity for extracellular matrix (ECM) remodeling is suggested by elevated expression of matrix metalloproteinases (Mmp3, Mmp9 and Mmp13), urokinase-type plasminogen activator (Plau) and secreted protease inhibitors (Serpina3g, Serpin2 and Lcn2).
Gene_expression (expression) of Mmp3 in extracellular matrix associated with metalloproteinase
17) Confidence 0.34 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2529338 Disease Relevance 0.43 Pain Relevance 0.09
Among a wide range of MMPs tested, only MMP-3 was over-expressed in the aortic aneurysm samples.
Gene_expression (expressed) of MMP-3 associated with metalloproteinase and aneurism
18) Confidence 0.31 Published 2004 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC526392 Disease Relevance 1.20 Pain Relevance 0.21
Based on these and our own observations, we maintain that MMP-3 over-expression may occur in aneurysm segments.
Gene_expression (-) of MMP-3 associated with aneurism
19) Confidence 0.31 Published 2004 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC526392 Disease Relevance 0.94 Pain Relevance 0.16
Based on these and our own observations, we maintain that MMP-3 over-expression may occur in aneurysm segments.
Gene_expression (expression) of MMP-3 associated with aneurism
20) Confidence 0.31 Published 2004 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC526392 Disease Relevance 0.95 Pain Relevance 0.18

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