INT140223

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 13.10
Pain Relevance 5.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl2) extracellular region (Ccl2) cytoskeleton organization (Ccl2)
cytoplasm (Ccl2)
Anatomy Link Frequency
microglia 5
T-cell 2
sensory neurons 1
plaques 1
lung 1
Ccl2 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 453 99.96 Very High Very High Very High
Inflammation 263 99.68 Very High Very High Very High
spinal dorsal horn 20 99.48 Very High Very High Very High
Pain 11 99.44 Very High Very High Very High
corticosteroid 8 97.88 Very High Very High Very High
Hyperalgesia 6 95.68 Very High Very High Very High
Multiple sclerosis 258 94.96 High High
dorsal root ganglion 4 93.72 High High
cytokine 186 93.00 High High
Spinal cord 134 91.40 High High
Disease Link Frequency Relevance Heat
Cancer 40 100.00 Very High Very High Very High
INFLAMMATION 275 99.68 Very High Very High Very High
Pain 8 99.44 Very High Very High Very High
Disease 440 99.40 Very High Very High Very High
Multiple Sclerosis 407 98.88 Very High Very High Very High
Recurrence 65 98.36 Very High Very High Very High
Hematological Disease 4 97.36 Very High Very High Very High
Diabetes Mellitus 154 97.04 Very High Very High Very High
Cardiovascular Disease 12 95.76 Very High Very High Very High
Hyperalgesia 8 95.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together with data from CCR2-deficient mice, these present data confirm a key role of CCL2/CCR2 axis in pain pathways and suggest that inhibiting this axis may result in novel pain therapies.
Regulation (role) of CCL2 associated with pain
1) Confidence 0.45 Published 2007 Journal Neuroscience Section Abstract Doc Link 17870246 Disease Relevance 0.84 Pain Relevance 0.78
Second, previous studies suggested the involvement of CCL2, CCL7, CCL8, CCL5 and CCL3 molecules in the development of plaques [39,46].
Regulation (involvement) of CCL2 in plaques
2) Confidence 0.44 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.40 Pain Relevance 0.28
Together, our data provide strong evidence that the chemical mediator CCL2 is released from tumor cells and evokes phenotypic changes in sensory neurons, including increases in voltage-gated Ca2+ channels that likely underlie the mechanical hyperalgesia in the fibrosarcoma cancer model.
Regulation (changes) of CCL2 in sensory neurons associated with fibrosarcoma, hyperalgesia and cancer
3) Confidence 0.39 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17881535 Disease Relevance 1.54 Pain Relevance 0.70
The deletion of the CCR2 [a receptor for monocyte chemoattractant protein-1 (MCP-1 or CCL2)] gene in Tg2576 mice reduced the number of microglia and impaired A?
Regulation (deletion) of MCP-1 in microglia
4) Confidence 0.36 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430555 Disease Relevance 1.06 Pain Relevance 0.09
The deletion of the CCR2 [a receptor for monocyte chemoattractant protein-1 (MCP-1 or CCL2)] gene in Tg2576 mice reduced the number of microglia and impaired A?
Regulation (deletion) of CCL2 in microglia
5) Confidence 0.36 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430555 Disease Relevance 1.06 Pain Relevance 0.09
Chemokines, especially MCP-1 and FNK, have been suggested to contribute to microglia activation [4,31,32].
Regulation (especially) of MCP-1 in microglia associated with chemokine
6) Confidence 0.34 Published 2010 Journal Mol Pain Section Body Doc Link PMC2857828 Disease Relevance 0.33 Pain Relevance 0.52
Chemokines, especially MCP-1 and FNK, have been suggested to contribute to microglia activation [4,31,32].
Regulation (contribute) of MCP-1 in microglia associated with chemokine
7) Confidence 0.34 Published 2010 Journal Mol Pain Section Body Doc Link PMC2857828 Disease Relevance 0.33 Pain Relevance 0.52
The deletion of the CCR2 [a receptor for monocyte chemoattractant protein-1 (MCP-1 or CCL2)] gene in Tg2576 mice reduced the number of microglia and impaired A?
Regulation (deletion) of chemoattractant protein-1 in microglia
8) Confidence 0.32 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430555 Disease Relevance 1.06 Pain Relevance 0.09
The up-regulation of CCL3 and CCL4 vs. down-regulation of CCL2 suggests opposed functions of these chemokines in the disease process in T1D.
Regulation (regulation) of CCL2 associated with chemokine, diabetes mellitus and disease
9) Confidence 0.30 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 1.06 Pain Relevance 0.16
However, it is unclear whether the biotinylated CCL2 reagent available to us is useful for identifying cognate receptor expression because we observed similar high background binding of this reagent to T cells in WT and CCR2 KO mice.
Spec (whether) Regulation (useful) of CCL2 in T cells
10) Confidence 0.28 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0.07
With the exception of well defined changes in the CCL2, CCL3 and CCL5 levels in the CSF during relapses, most investigators observed no differences in various clinical forms of the disease [56,61,64,66].
Neg (exception) Regulation (changes) of CCL2 associated with disease and recurrence
11) Confidence 0.26 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 2.31 Pain Relevance 0.75
This study emphasizes the importance of CCL2 and CCL3 in the development of active EAE in rats.
Regulation (importance) of CCL2 associated with multiple sclerosis
12) Confidence 0.26 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.38 Pain Relevance 0.15
CCL2, CCL3, CCL5, CCL7, CCL8, etc...) are transcriptionally regulated during inflammation and mediate the recruitment of inflammatory cells to target tissues.
Regulation (regulated) of CCL2 associated with inflammation
13) Confidence 0.26 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.55 Pain Relevance 0.65
The concentrations of CCL2, CCL3, CCL5, TNF?
Regulation (concentrations) of CCL2
14) Confidence 0.23 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 0.13 Pain Relevance 0.11
Consistent with the first experiment, there was a significant effect of mechanical ventilation on lung levels of KC/CXCL1, MCP1/CCL2, MIP1?
Regulation (effect) of CCL2 in lung
15) Confidence 0.08 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0.44 Pain Relevance 0.25
We measured and compared the ratio of elevated levels of regulated on activation normally T-cell expressed and secreted (RANTES), monocytic chemotactic peptide-1 (MCP-1), soluble (s) P-selectin and sL-selectin after PCI.
Regulation (regulated) of monocytic chemotactic peptide-1 in T-cell
16) Confidence 0.00 Published 2006 Journal Platelets Section Abstract Doc Link 17127484 Disease Relevance 0.60 Pain Relevance 0.21

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