INT140224

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Context Info
Confidence 0.72
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 32
Total Number 32
Disease Relevance 26.91
Pain Relevance 9.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl2) extracellular region (Ccl2) cytoskeleton organization (Ccl2)
cytoplasm (Ccl2)
Anatomy Link Frequency
macrophage 7
monocyte 6
microglia 2
sensory neurons 1
brain 1
Ccl2 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 606 100.00 Very High Very High Very High
cytokine 462 100.00 Very High Very High Very High
ischemia 61 100.00 Very High Very High Very High
Central nervous system 331 99.14 Very High Very High Very High
antagonist 57 98.80 Very High Very High Very High
Inflammation 922 98.72 Very High Very High Very High
Pain 11 96.44 Very High Very High Very High
Spinal cord 145 94.20 High High
Multiple sclerosis 470 93.88 High High
Hyperalgesia 5 93.80 High High
Disease Link Frequency Relevance Heat
Disease 559 100.00 Very High Very High Very High
Cv General 4 Under Development 19 100.00 Very High Very High Very High
Infection 207 99.92 Very High Very High Very High
Obesity 402 99.84 Very High Very High Very High
Cancer 147 99.76 Very High Very High Very High
Central Nervous System Disease 288 99.14 Very High Very High Very High
INFLAMMATION 1048 98.72 Very High Very High Very High
Insulin Resistance 55 97.96 Very High Very High Very High
Sprains And Strains 201 97.68 Very High Very High Very High
Lymphatic System Cancer 68 97.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In humans, there are 27 CC chemokines, most of which including CCL2, CCL7, CCL11, CCL8, CCL13, CCL1, CCL5, CCL16, CCL14, CCL15, CCL23, CCL18, CCL3 and CCL4, respectively, are encoded as a cluster within chromosome 17q11.
Localization (respectively) of CCL2 associated with chemokine
1) Confidence 0.72 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.52 Pain Relevance 0.75
Besides establishing the CCR characteristics in RRMS and SPMS, this study also suggests that targeting the CCL2-CCR2 axis with specific CCR2 antagonist or a combination of CCR2 and CCR5 antagonists might be an option in SPMS, whereas CCR5 antagonists alone may be considered in RRMS.
Localization (targeting) of CCL2 associated with antagonist
2) Confidence 0.72 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.50 Pain Relevance 0.29
In humans, there are 27 CC chemokines, most of which including CCL2, CCL7, CCL11, CCL8, CCL13, CCL1, CCL5, CCL16, CCL14, CCL15, CCL23, CCL18, CCL3 and CCL4, respectively, are encoded as a cluster within chromosome 17q11.
Localization (including) of CCL2 associated with chemokine
3) Confidence 0.72 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.45 Pain Relevance 0.69
Thus, the functional involvement of CCL chemokines during EAE is not only restricted to a well orchestrated recruitment of dendritic cells, monocytes, macrophages, T effector and regulatory cells into the CNS, but also includes a temporal and spatial regulation of TH1 (CCL3, CCL5) or TH2 (CCL2, CCL22) polarization, and monocyte, macrophage and microglial activation (CCL1, CCL2, CCL7, CCL8).
Localization (regulation) of CCL2 in macrophages associated with chemokine, multiple sclerosis and central nervous system
4) Confidence 0.72 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.08 Pain Relevance 0.23
, CSF3R) and macrophage recruitment (CCL2) and/or perhaps a tissue remodeling response through activation of MMP9.
Localization (recruitment) of CCL2 in macrophage
5) Confidence 0.72 Published 2010 Journal Respir Res Section Body Doc Link PMC2892448 Disease Relevance 0.78 Pain Relevance 0.07
Together, our data provide strong evidence that the chemical mediator CCL2 is released from tumor cells and evokes phenotypic changes in sensory neurons, including increases in voltage-gated Ca2+ channels that likely underlie the mechanical hyperalgesia in the fibrosarcoma cancer model.
Localization (released) of CCL2 in sensory neurons associated with fibrosarcoma, hyperalgesia and cancer
6) Confidence 0.70 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17881535 Disease Relevance 1.53 Pain Relevance 0.69
For example, MCP-1/Ccl2 can mobilize EPCs and monocyte populations.
Localization (mobilize) of MCP-1 in monocyte
7) Confidence 0.69 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733377 Disease Relevance 0.66 Pain Relevance 0.13
For example, MCP-1/Ccl2 can mobilize EPCs and monocyte populations.
Localization (mobilize) of Ccl2 in monocyte
8) Confidence 0.69 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733377 Disease Relevance 0.66 Pain Relevance 0.13
Through secretion of various chemokines such as CXCL10, CCL2 and BAFF, astrocytes play an important role in shaping adaptive immune responses in the CNS [32].
Localization (secretion) of CCL2 in astrocytes associated with chemokine
9) Confidence 0.60 Published 2007 Journal J Transl Med Section Body Doc Link PMC1914111 Disease Relevance 0.86 Pain Relevance 0.22
MCP-1 is decreased, and is positively correlated with brain A?
Localization (correlated) of MCP-1 in brain
10) Confidence 0.58 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2955708 Disease Relevance 0.47 Pain Relevance 0.07
In this study, we didn't find any enhanced motility of microglia after local application of MCP-1, FKN, BDNF, NGF, IL-1?
Localization (application) of MCP-1 in microglia
11) Confidence 0.56 Published 2010 Journal Mol Pain Section Body Doc Link PMC2857828 Disease Relevance 0.18 Pain Relevance 0.61
CCL2 is secreted in the course of T. cruzi infection and participates in T. cruzi uptake and activation of trypanocidal activity in macrophages.
Localization (secreted) of CCL2 in macrophages associated with infection
12) Confidence 0.54 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2953483 Disease Relevance 0.62 Pain Relevance 0.19
Cytokine group (12 transcripts mRNAs): CCL2, IL1B, IL6, CSF2, CSF3, IFNG, IRAK1, IRAK2, NLRP2, KAT2B, STAT1, and EGR1 (All abbreviations are current Entrez Gene official symbols and official full names are presented in Table S1).
Localization (group) of CCL2 associated with cytokine
13) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682759 Disease Relevance 0.19 Pain Relevance 0.11
The latter factors can induce the secretion of IL-8 and MCP-1 in RPE cells in vitro

[120, 121].

Localization (secretion) of MCP-1
14) Confidence 0.49 Published 2008 Journal PPAR Research Section Body Doc Link PMC2276614 Disease Relevance 0.84 Pain Relevance 0.18
The ratios of extended/retracted processes or distances of microglia at time 30 min to 0 min after application of 10 ng/ml MCP-1 (n = 6 slices/5 mice) or FNK (n = 5 slices/5 mice) were summarized in Fig. 1.
Localization (summarized) of MCP-1 in microglia
15) Confidence 0.49 Published 2010 Journal Mol Pain Section Body Doc Link PMC2857828 Disease Relevance 0.14 Pain Relevance 0.47
Among these were MCP-1 (CCL2), MIG (CXCL9), IP-10 (CCL10), and I-TAC (CXCL11).
Localization (were) of CCL2
16) Confidence 0.49 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 0.84 Pain Relevance 0.09
Among these were MCP-1 (CCL2), MIG (CXCL9), IP-10 (CCL10), and I-TAC (CXCL11).
Localization (were) of MCP-1
17) Confidence 0.49 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 0.84 Pain Relevance 0.09
Of interest, the ability of MSC cultures of secreting high levels of angiogenic cytokines, such as VEGF, IL-8, angiogenin and CCL2, was significantly (p<0.01) enhanced by the concomitant presence of lymphoma cells.
Localization (secreting) of CCL2 associated with lymphatic system cancer and cytokine
18) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886845 Disease Relevance 0.87 Pain Relevance 0.09
Gene expression for MCP-1 and TNF-?
Localization (for) of MCP-1
19) Confidence 0.35 Published 2008 Journal Part Fibre Toxicol Section Body Doc Link PMC2546436 Disease Relevance 0.96 Pain Relevance 0
It is also established that JEV infection leads to massive upregulation of inflammatory cytokine levels [19], and neurons also respond to infection by secreting CCL2, and type I and II IFNs [21].
Localization (secreting) of CCL2 in neurons associated with inflammation, infection and cytokine
20) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780913 Disease Relevance 0.77 Pain Relevance 0.27

General Comments

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