INT140237

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Context Info
Confidence 0.46
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.31
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ADRBK1, MC1R) pigmentation (MC1R) cytosol (ADRBK1)
signal transduction (ADRBK1) aging (ADRBK1) signal transducer activity (MC1R)
Anatomy Link Frequency
melanocytes 3
ADRBK1 (Homo sapiens)
MC1R (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 10 100.00 Very High Very High Very High
agonist 1 93.52 High High
Disease Link Frequency Relevance Heat
Skin Cancer 4 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have shown that MC1R desensitization is mediated by two GRKs expressed in melanocytes and melanoma cells, GRK2 and GRK6.
Gene_expression (expressed) of GRK2 in melanocytes Positive_regulation (mediated) of Gene_expression (desensitization) of MC1R in melanocytes associated with melanocortin 1 receptor and skin cancer
1) Confidence 0.46 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17130136 Disease Relevance 0.31 Pain Relevance 0.68

General Comments

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