INT140245

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Context Info
Confidence 0.36
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.65
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

anatomical structure formation involved in morphogenesis (Gli3) intracellular (Gli3) cilium (Gli3)
DNA binding (Gli3) cytoplasm (Gli3) cytosol (Gli3)
Anatomy Link Frequency
nerve 1
Gli3 (Mus musculus)
Pain Link Frequency Relevance Heat
Painful diabetic neuropathy 27 100.00 Very High Very High Very High
diabetic neuropathy 10 100.00 Very High Very High Very High
allodynia 39 99.98 Very High Very High Very High
Pain 20 96.28 Very High Very High Very High
Nerve growth factor 45 94.48 High High
Trk A 11 94.16 High High
hypoalgesia 2 87.76 High High
Brush evoked pain 2 87.24 High High
Inflammation 15 87.20 High High
COX2 29 79.84 Quite High
Disease Link Frequency Relevance Heat
Diabetic Neuropathy 42 100.00 Very High Very High Very High
Neuropathic Pain 50 99.98 Very High Very High Very High
Diabetes Mellitus 52 99.08 Very High Very High Very High
Hyperglycemia 4 96.68 Very High Very High Very High
Pain 18 96.28 Very High Very High Very High
Obesity 6 95.96 Very High Very High Very High
Hypoalagesia 2 87.76 High High
INFLAMMATION 23 87.20 High High
Congenital Anomalies 24 81.84 Quite High
Peripheral Neuropathy 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study was aimed at characterization of PDN in leptin-deficient (ob/ob) mice, a model of type 2 diabetes with relatively mild hyperglycemia and obesity. ob/ob mice ( approximately 11 weeks old) clearly developed manifest sciatic motor nerve conduction velocity (MNCV) and hind-limb digital sensory nerve conduction velocity (SNCV) deficits, thermal hypoalgesia, tactile allodynia, and a remarkable ( approximately 78%) loss of intraepidermal nerve fibers.
PDN Binding (characterization) of in nerve associated with hyperglycemia, brush evoked pain, diabetes mellitus, diabetic neuropathy, obesity and hypoalgesia
1) Confidence 0.36 Published 2006 Journal Diabetes Section Abstract Doc Link 17130477 Disease Relevance 1.74 Pain Relevance 0.50
Here we are the first to report a role for this protein kinase in mechanical allodynia associated with PDN in an animal model of type 2 diabetes.
PDN Binding (associated) of associated with painful diabetic neuropathy, allodynia and diabetes mellitus
2) Confidence 0.18 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 0.91 Pain Relevance 0.96
The majority of naturally occurring mutations in the ATRX gene occur in the ADD and helicase domains [22].
ADD Binding (occur) of
3) Confidence 0.04 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1464382 Disease Relevance 0 Pain Relevance 0

General Comments

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