INT140247

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Context Info
Confidence 0.33
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 3.15
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ngfr) signal transduction (Ngfr) nuclear envelope (Ngfr)
Golgi apparatus (Ngfr) plasma membrane (Ngfr) nucleus (Ngfr)
Anatomy Link Frequency
sciatic nerve 6
Ngfr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bDMF 213 99.60 Very High Very High Very High
Sciatic nerve 72 98.96 Very High Very High Very High
Nerve growth factor 8 96.52 Very High Very High Very High
unmyelinated 4 83.20 Quite High
Hyperalgesia 2 80.80 Quite High
Spinal cord 89 71.36 Quite High
dorsal root ganglion 2 60.36 Quite High
Dorsal column 13 5.00 Very Low Very Low Very Low
Central nervous system 12 5.00 Very Low Very Low Very Low
halothane 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nervous System Injury 9 98.64 Very High Very High Very High
Diabetes Mellitus 18 97.32 Very High Very High Very High
Sciatic Neuropathy 32 83.52 Quite High
Hyperalgesia 2 80.80 Quite High
Nociception 10 75.00 Quite High
Neuropathic Pain 6 75.00 Quite High
Ganglion Cysts 3 60.36 Quite High
Spinal Cord Injury 37 59.68 Quite High
Overdose 4 21.64 Low Low
Injury 32 10.52 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Osmopump delivery prevented the decline of NGFR-TrkA, insulin receptor (P < 0.05), and IGF-IR (P < 0.005) expressions in DRGs and improved NGF content (P < 0.05) in sciatic nerve.
Negative_regulation (prevented) of Negative_regulation (decline) of NGFR-TrkA in sciatic nerve associated with nerve growth factor and sciatic nerve
1) Confidence 0.33 Published 2006 Journal Diabetes Section Abstract Doc Link 17130507 Disease Relevance 1.36 Pain Relevance 0.46
Osmopump delivery prevented the decline of NGFR-TrkA, insulin receptor (P < 0.05), and IGF-IR (P < 0.005) expressions in DRGs and improved NGF content (P < 0.05) in sciatic nerve.
Negative_regulation (prevented) of Negative_regulation (decline) of NGFR-TrkA in sciatic nerve associated with nerve growth factor and sciatic nerve
2) Confidence 0.33 Published 2006 Journal Diabetes Section Abstract Doc Link 17130507 Disease Relevance 1.36 Pain Relevance 0.46
BDNF is upregulated and p75NTR is down-regulated in sensory neurons after sciatic nerve injury [12], [35].
Negative_regulation (down) of Negative_regulation (regulated) of p75NTR in sciatic nerve associated with nervous system injury, sciatic nerve and bdmf
3) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2246162 Disease Relevance 0.43 Pain Relevance 0.67

General Comments

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