INT14026

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Context Info
Confidence 0.68
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 24
Total Number 24
Disease Relevance 10.84
Pain Relevance 4.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
pollen 2
polymorphonuclear leucocytes 2
erythrocytes 1
suppressor T cells 1
red blood cells 1
Igh-6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 68 99.90 Very High Very High Very High
Angina 1 99.60 Very High Very High Very High
qutenza 10 99.28 Very High Very High Very High
intrathecal 44 98.72 Very High Very High Very High
c fibre 2 98.08 Very High Very High Very High
agonist 2 97.82 Very High Very High Very High
Bile 2 97.80 Very High Very High Very High
Opioid 4 97.02 Very High Very High Very High
Demyelination 6 96.24 Very High Very High Very High
Neuritis 12 96.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Measles 4 99.98 Very High Very High Very High
Seronegative Spondarthritis 4 99.90 Very High Very High Very High
Gallstones 1 99.84 Very High Very High Very High
Syndrome 16 99.78 Very High Very High Very High
Biliary Liver Cirrhosis 11 99.72 Very High Very High Very High
Infarction 2 99.60 Very High Very High Very High
Meningoencephalitis 24 99.08 Very High Very High Very High
Immunodeficiency 3 99.00 Very High Very High Very High
Rhinitis 35 98.68 Very High Very High Very High
Arthritis 69 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Accumulation of immunoglobulin across the 'blood-nerve barrier' in spinal roots in adoptive transfer experimental autoimmune neuritis.
Positive_regulation (Accumulation) of immunoglobulin in spinal associated with experimental autoimmune neuritis and neuritis
1) Confidence 0.68 Published 2002 Journal Neuropathol. Appl. Neurobiol. Section Title Doc Link 12445165 Disease Relevance 0.35 Pain Relevance 0.22
In the post-infarction syndrome, only the M immunoglobulin content was increased.
Positive_regulation (increased) of M immunoglobulin associated with syndrome and infarction
2) Confidence 0.58 Published 1980 Journal Kardiologiia Section Abstract Doc Link 7412084 Disease Relevance 0.55 Pain Relevance 0.10
Serum measles immunoglobulin M level was elevated (183 AU).
Positive_regulation (elevated) of immunoglobulin M associated with measles
3) Confidence 0.52 Published 2006 Journal Brain Dev. Section Abstract Doc Link 16504441 Disease Relevance 0.86 Pain Relevance 0.17
The involvement of the nucleus accumbens in neuroimmunostimulation was demonstrated during activation of opioid mu receptors with the selective agonist DAGO (100 microg/kg); single doses of this agent to sham-operated (control) Wistar rats induced significant increases in the numbers of direct IgM antibody-forming and total rosette-forming cells after immunization with sheep erythrocytes.
Positive_regulation (increases) of IgM in erythrocytes associated with nucleus accumbens, immunization, agonist and opioid
4) Confidence 0.50 Published 2002 Journal Neurosci. Behav. Physiol. Section Abstract Doc Link 12403006 Disease Relevance 0.18 Pain Relevance 0.48
Immunoglobulin accumulation was expressed as counts/min/mg in fixative-perfused roots as a percentage of that in serum, measured 24 h after intraperitoneal injection of 0.1 micro Ci 125I-labelled immunoglobulin.
Positive_regulation (accumulation) of Immunoglobulin
5) Confidence 0.49 Published 2002 Journal Neuropathol. Appl. Neurobiol. Section Abstract Doc Link 12445165 Disease Relevance 0.39 Pain Relevance 0.24
The first abnormality detected in AT-EAN was a rapid increase in the passage of immunoglobulin into spinal roots, together with endoneurial infiltration of T lymphocytes and polymorphonuclear leucocytes.
Positive_regulation (increase) of immunoglobulin in T lymphocytes
6) Confidence 0.49 Published 2002 Journal Neuropathol. Appl. Neurobiol. Section Abstract Doc Link 12445165 Disease Relevance 0.30 Pain Relevance 0.22
Immunoglobulin accumulation in the roots of normal rats was 3 +/- 1% (mean +/- SE), but this first increased 3(1/2) days after cell injection, peaked at 22 +/- 2% on day 4(1/2), and declined to normal by day 8.
Positive_regulation (accumulation) of Immunoglobulin
7) Confidence 0.49 Published 2002 Journal Neuropathol. Appl. Neurobiol. Section Abstract Doc Link 12445165 Disease Relevance 0.39 Pain Relevance 0.24
Accumulation of immunoglobulin was maximal during the worsening of neurological deficit, and declined rapidly before the onset of neurological recovery.
Positive_regulation (Accumulation) of immunoglobulin
8) Confidence 0.49 Published 2002 Journal Neuropathol. Appl. Neurobiol. Section Abstract Doc Link 12445165 Disease Relevance 0.28 Pain Relevance 0.21
Single doses of DAGO (100 microg/kg) in sham-operated control Wistar rats induced significant increases in the numbers of direct IgM-antibody-forming and total rosette-forming cells at the peak of the immune response after immunization with sheet red blood cells.
Positive_regulation (increases) of IgM in red blood cells associated with immunization
9) Confidence 0.49 Published 2001 Journal Neurosci. Behav. Physiol. Section Abstract Doc Link 11430578 Disease Relevance 0.17 Pain Relevance 0.15
Patients with psoriatic arthritis had elevated B cells and immunoglobulin levels which fell with sulfasalazine therapy.
Positive_regulation (elevated) of immunoglobulin in B cells associated with seronegative spondarthritis and arthritis
10) Confidence 0.36 Published 1991 Journal J. Rheumatol. Section Abstract Doc Link 1684619 Disease Relevance 0.71 Pain Relevance 0.30
In our experience, IgE in the CSF and serum in eosinophilic meningoencephalitis caused by Angiostrongylus cantonensis is the immunoglobulin that shows the largest increase compared to IgA, IgG and IgM.
Positive_regulation (increase) of immunoglobulin associated with rhinitis and meningoencephalitis
11) Confidence 0.32 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2607252 Disease Relevance 0.43 Pain Relevance 0.17
Results revealed that serum IgM levels dramatically increased and achieved a maximum level on day 20 (Fig. 2A).
Positive_regulation (increased) of IgM
12) Confidence 0.26 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2816374 Disease Relevance 1.08 Pain Relevance 0.15
The first abnormality detected in AT-EAN was a rapid increase in the passage of immunoglobulin into spinal roots, together with endoneurial infiltration of T lymphocytes and polymorphonuclear leucocytes.
Positive_regulation (increase) of immunoglobulin in polymorphonuclear leucocytes
13) Confidence 0.17 Published 2002 Journal Neuropathol. Appl. Neurobiol. Section Abstract Doc Link 12445165 Disease Relevance 0.30 Pain Relevance 0.22
In conclusion, the exacerbated pulmonary neutrophil recruitment caused by the capsaicin neonatal treatment is unrelated to increase in serum immunoglobulin antibodies, and suggests a protective role for C-fibers in attenuating the allergic neutrophil infiltration.
Positive_regulation (increase) of immunoglobulin in neutrophil associated with c fibre, qutenza and hypersensitivity
14) Confidence 0.16 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11399269 Disease Relevance 0.10 Pain Relevance 0.76
In our experience, IgE in the CSF and serum in eosinophilic meningoencephalitis caused by Angiostrongylus cantonensis is the immunoglobulin that shows the largest increase compared to IgA, IgG and IgM.
Positive_regulation (increase) of IgM associated with rhinitis and meningoencephalitis
15) Confidence 0.14 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2607252 Disease Relevance 0.42 Pain Relevance 0.17
Likewise, decrease in IgM and increase in Hb, as well as wellbeing (Karnofsky performance scale), were observed.[83] T. cordifolia prevents antitubercular drugs[8485] and bile salts[86] induced hepatic damage, x and obstructive jaundice.[87] The extract has also exhibited in vitro inactivating property against hepatitis B and E surface antigens in 48 to 72 hours.[88]

ANTI-HYPERGLYCEMIC ACTIVITY

Positive_regulation (increase) of IgM in bile associated with bile, hepatitis and obstructive jaundice
16) Confidence 0.11 Published 2010 Journal International Journal of Ayurveda Research Section Body Doc Link PMC2924974 Disease Relevance 0.64 Pain Relevance 0.08
Both patients initially had negative MAT and IgM results in their acute serum sample.
Positive_regulation (results) of IgM
17) Confidence 0.09 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2271056 Disease Relevance 0.50 Pain Relevance 0
Criteria for inclusion in the study are: 1) patient age above 7 and less than 70 years, 2) renal biopsy diagnostic for IgAN based on immunohistologic staining for IgA that is greater than or equal to staining for IgG and IgM after the biopsy report has be evaluated by one of the study pathologists (entry into the study does not depend upon any specific time interval between the time of the renal biopsy and the time of entry), 3) ability to swallow the oral medications used in the study, 4) signed informed consent by subjects ?
Positive_regulation (staining) of IgM
18) Confidence 0.05 Published 2004 Journal BMC Nephrol Section Body Doc Link PMC415550 Disease Relevance 0 Pain Relevance 0
The presence of increased levels of mitochondrial antibodies without any other auto-antibody associated with a chronic non-surgical cholestasis and an increased level of immunoglobulin M is still strongly suggestive of primary biliary cirrhosis.
Positive_regulation (increased) of immunoglobulin associated with biliary liver cirrhosis and gallstones
19) Confidence 0.02 Published 1988 Journal Ann Med Interne (Paris) Section Abstract Doc Link 3364874 Disease Relevance 0.92 Pain Relevance 0.13
First, we sought to determine the impact that diesel exhaust inhalation during the differentiation periods of the immune system had upon the elevation of immunoglobulin E against Japanese cedar pollen.
Positive_regulation (elevation) of immunoglobulin in pollen
20) Confidence 0.01 Published 2002 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC101391 Disease Relevance 0.41 Pain Relevance 0

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