INT140265

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Context Info
Confidence 0.67
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.52
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Reg2)
Anatomy Link Frequency
hepatocytes 1
NIT-1 1
Reg2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 4 94.72 High High
Inflammation 10 91.92 High High
Paracetamol 1 62.88 Quite High
chemokine 14 14.00 Low Low
Glutamate 4 5.00 Very Low Very Low Very Low
diabetic neuropathy 4 5.00 Very Low Very Low Very Low
member 8 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Crohn's disease 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 308 99.24 Very High Very High Very High
Congenital Anomalies 2 96.92 Very High Very High Very High
INFLAMMATION 14 94.36 High High
Targeted Disruption 4 80.48 Quite High
Stress 2 77.88 Quite High
Hepatotoxicity 1 75.00 Quite High
Hepatitis 1 69.40 Quite High
Acute Liver Failure 1 64.00 Quite High
Chronic Renal Failure 2 62.36 Quite High
Renal Disease 10 62.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because the Reg2 gene was activated between 6 and 24 hours after hepatectomy in wild-type mice, Reg2 could mediate the TNF-alpha/IL-6 priming signaling by exerting a negative feed-back on STAT3/IL-6 activation to allow the hepatocytes to progress through the cell cycle.
Positive_regulation (activated) of Reg2 in hepatocytes
1) Confidence 0.67 Published 2006 Journal Hepatology Section Abstract Doc Link 17133485 Disease Relevance 0.50 Pain Relevance 0.06
Reg2 was upregulated in islets from NOD RIP-HuIFN?
Positive_regulation (upregulated) of Reg2
2) Confidence 0.41 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 1.01 Pain Relevance 0.09
up-regulates Reg1 and Reg2 genes in NIT-1 cells.
Positive_regulation (regulates) of Reg2 in NIT-1
3) Confidence 0.18 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 1.01 Pain Relevance 0.09

General Comments

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