INT14027

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Context Info
Confidence 0.69
First Reported 1988
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 29
Total Number 30
Disease Relevance 3.63
Pain Relevance 4.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prep) peptidase activity (Prep) nucleus (Prep)
cytoplasm (Prep)
Anatomy Link Frequency
hypothalamus 5
neurons 3
striatum 1
PVN 1
olfactory tubercle 1
Prep (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 181 100.00 Very High Very High Very High
Nerve growth factor 6 100.00 Very High Very High Very High
Enkephalin 38 98.96 Very High Very High Very High
cocaine 77 98.26 Very High Very High Very High
Acupuncture 7 98.12 Very High Very High Very High
Hippocampus 9 95.36 Very High Very High Very High
withdrawal 10 95.08 Very High Very High Very High
Morphine 8 94.64 High High
antagonist 3 93.68 High High
monoamine 4 91.20 High High
Disease Link Frequency Relevance Heat
Stress 30 99.82 Very High Very High Very High
Atherosclerosis 7 99.44 Very High Very High Very High
Lordosis 15 98.72 Very High Very High Very High
Apoptosis 19 92.92 High High
Body Weight 5 91.52 High High
Urological Neuroanatomy 4 91.36 High High
Disorder Of Lipid Metabolism 10 90.64 High High
Cv Unclassified Under Development 37 84.80 Quite High
Injury 5 75.00 Quite High
Reperfusion Injury 14 70.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Slot blot hybridization analysis indicates that the levels of PE mRNA in the ventromedial hypothalamus of ovariectomized rats increase 3.1-fold after 2 weeks of estrogen replacement.
Positive_regulation (increase) of PE mRNA in hypothalamus
1) Confidence 0.69 Published 1988 Journal Mol. Endocrinol. Section Abstract Doc Link 2464133 Disease Relevance 0 Pain Relevance 0
The latency of the estrogen-induced elevation in PE mRNA levels was found to be relatively short: PE mRNA levels were increased 2-fold within 1 h of estrogen replacement.
Positive_regulation (increased) of PE mRNA
2) Confidence 0.68 Published 1989 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 2927283 Disease Relevance 0 Pain Relevance 0
These results suggest that estrogen rapidly increases PE mRNA levels through a mechanism that probably involves alterations in both the rate of appearance and the rate of degradation of the message.
Positive_regulation (increases) of PE mRNA
3) Confidence 0.68 Published 1989 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 2927283 Disease Relevance 0 Pain Relevance 0
Progesterone treatment attenuated this decline, prolonging the estrogen-induced elevation of PE mRNA levels.
Positive_regulation (elevation) of PE mRNA
4) Confidence 0.68 Published 1989 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 2927283 Disease Relevance 0 Pain Relevance 0
Estrogen treatment increased hybridization density, the number of PE mRNA-expressing cells and PE mRNA (grains) level/cell in the VMN of normal adult female rats.
Positive_regulation (increased) of PE mRNA in VMN
5) Confidence 0.46 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221919 Disease Relevance 0 Pain Relevance 0.22
The increase in PE mRNA levels is due to both a 63% increase in the number of detectable PE mRNA-containing neurons and a 2.0-fold increase in the levels of PE mRNA per enkephalinergic neuron (1.63 x 2.0 = 3.3-fold overall induction).
Positive_regulation (increase) of PE mRNA in neurons
6) Confidence 0.46 Published 1988 Journal Mol. Endocrinol. Section Abstract Doc Link 2464133 Disease Relevance 0 Pain Relevance 0
The increase in PE mRNA levels is due to both a 63% increase in the number of detectable PE mRNA-containing neurons and a 2.0-fold increase in the levels of PE mRNA per enkephalinergic neuron (1.63 x 2.0 = 3.3-fold overall induction).
Positive_regulation (increase) of PE mRNA in neurons
7) Confidence 0.46 Published 1988 Journal Mol. Endocrinol. Section Abstract Doc Link 2464133 Disease Relevance 0 Pain Relevance 0
Soluble prolyl endopeptidase activity was higher in the renal cortex of the chronic salt-loaded rats than in the control rats.
Positive_regulation (higher) of prolyl endopeptidase in renal cortex
8) Confidence 0.46 Published 2001 Journal Regul. Pept. Section Abstract Doc Link 11495689 Disease Relevance 0 Pain Relevance 0.17
The latency of the estrogen-induced elevation in PE mRNA levels was found to be relatively short: PE mRNA levels were increased 2-fold within 1 h of estrogen replacement.
Positive_regulation (elevation) of PE mRNA
9) Confidence 0.45 Published 1989 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 2927283 Disease Relevance 0 Pain Relevance 0
In this series of experiments, we examined the temporal qualities of this induction by determining both the latency of the estrogen-induced elevation in PE mRNA levels and the rate at which the message levels decline following removal of estrogen.
Spec (determining) Positive_regulation (elevation) of PE mRNA
10) Confidence 0.45 Published 1989 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 2927283 Disease Relevance 0 Pain Relevance 0
The PE mRNA induction in estrogen-treated androgenized rats correlated well with the lordosis scores obtained by manual stimulation testing.
Positive_regulation (induction) of PE mRNA associated with lordosis
11) Confidence 0.43 Published 1990 Journal Brain Res. Section Abstract Doc Link 1707724 Disease Relevance 0.25 Pain Relevance 0.05
Such 3D measurements reveal that cocaine produces large, consistent rightward shifts of the 3D structure along the price axis (increases in Pe).
Positive_regulation (increases) of Pe associated with cocaine
12) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994896 Disease Relevance 0 Pain Relevance 0.08
The increase in PE mRNA levels is due to both a 63% increase in the number of detectable PE mRNA-containing neurons and a 2.0-fold increase in the levels of PE mRNA per enkephalinergic neuron (1.63 x 2.0 = 3.3-fold overall induction).
Positive_regulation (increase) of PE mRNA in neurons
13) Confidence 0.40 Published 1988 Journal Mol. Endocrinol. Section Abstract Doc Link 2464133 Disease Relevance 0 Pain Relevance 0
Slot blot hybridization analysis of RNA isolated from the ventromedial hypothalamus indicated that estrogen treatment increased PE mRNA levels in the VL-VM of ovariectomized female rats (2.2-fold), but had no measurable effect on PE mRNA levels in gonadectomized males.
Positive_regulation (increased) of PE mRNA in hypothalamus
14) Confidence 0.40 Published 1990 Journal Brain Res. Section Abstract Doc Link 1707724 Disease Relevance 0.09 Pain Relevance 0.09
Unlike the genetic male, the androgenized females responded to estrogen treatment with a female-typical increase in PE mRNA levels (1.7-fold).
Positive_regulation (increase) of PE mRNA
15) Confidence 0.40 Published 1990 Journal Brain Res. Section Abstract Doc Link 1707724 Disease Relevance 0.23 Pain Relevance 0.06
The data indicate that an apparent 'threshold' level of PE mRNA in VMN coincided wit display of behavior, and suggest further that high levels of PE mRNA, alone, are not sufficient for lordosis.
Positive_regulation (levels) of PE mRNA in VMN associated with lordosis
16) Confidence 0.38 Published 1990 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 2166200 Disease Relevance 0.27 Pain Relevance 0.09
In the hypothalamus both prolyl endopeptidase and dipeptidyl peptidase IV activities were concomitantly increased.
Positive_regulation (increased) of prolyl endopeptidase in hypothalamus
17) Confidence 0.34 Published 1996 Journal Pharmacol. Toxicol. Section Abstract Doc Link 8882344 Disease Relevance 0.17 Pain Relevance 0.54
Concomitant increases in hypothalamic prolyl endopeptidase and dipeptidyl peptidase activities may contribute to these changes.
Positive_regulation (increases) of prolyl endopeptidase
18) Confidence 0.34 Published 1996 Journal Pharmacol. Toxicol. Section Abstract Doc Link 8882344 Disease Relevance 0.17 Pain Relevance 0.52
Estradiol treatment led to a monotonic dose-dependent increase in PE mRNA level in VMN, while only a small effect was observed in POA at the higher estradiol doses.
Positive_regulation (increase) of PE mRNA in POA
19) Confidence 0.33 Published 1990 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 2166200 Disease Relevance 0.26 Pain Relevance 0.06
Stress induced by injection of hypertonic saline increased both CRH and PE mRNA levels in PVN.
Positive_regulation (increased) of PE mRNA in PVN associated with stress
20) Confidence 0.21 Published 1998 Journal Brain Res. Section Abstract Doc Link 9555022 Disease Relevance 0.35 Pain Relevance 0.09

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