INT140282

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Context Info
Confidence 0.39
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.09
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
C cells 2
Crh (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 18 99.84 Very High Very High Very High
Serotonin 2 96.92 Very High Very High Very High
Dopamine 1 94.92 High High
noradrenaline 1 94.40 High High
fluoxetine 1 91.12 High High
Endep 2 89.92 High High
depression 8 86.40 High High
antidepressant 1 86.40 High High
Kinase C 24 36.80 Quite Low
amygdala 16 25.28 Quite Low
Disease Link Frequency Relevance Heat
Stress 62 100.00 Very High Very High Very High
Reprotox - General 1 2 98.04 Very High Very High Very High
Neuroblastoma 4 96.92 Very High Very High Very High
Depression 8 86.40 High High
Sprains And Strains 9 84.36 Quite High
Aggression 57 81.48 Quite High
Targeted Disruption 35 77.28 Quite High
Mental Disorders 1 74.96 Quite High
Anxiety Disorder 31 5.00 Very Low Very Low Very Low
Hyponatremia 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increasing central CRF levels (via icv injections) (which would presumably increase activation of CRFR1) decreases maternal responding in maternally sensitized virgin rats [6].
Negative_regulation (decreases) of Positive_regulation (Increasing) of CRF
1) Confidence 0.39 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1821036 Disease Relevance 0.47 Pain Relevance 0.09
Furthermore, the ethanolic extract of Curcuma longa significantly reversed the swim stress-induced increases in serum corticotropin-releasing factor and cortisol levels.
Negative_regulation (reversed) of Positive_regulation (increases) of serum corticotropin-releasing factor associated with stress
2) Confidence 0.37 Published 2007 Journal J Ethnopharmacol Section Abstract Doc Link 17134862 Disease Relevance 0.43 Pain Relevance 0.44
The forskolin-stimulated CRH gene promoter activity is suppressed by dexamethasone in the BE(2)C cells which endogenously express CRH.
Negative_regulation (suppressed) of Positive_regulation (stimulated) of CRH gene in C cells associated with dexamethasone
3) Confidence 0.35 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0 Pain Relevance 0.18
The cAMP-induced CRH promoter activity is reduced in the deletion construct which does not contain CRE.
Negative_regulation (reduced) of Positive_regulation (induced) of CRH promoter
4) Confidence 0.35 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.19 Pain Relevance 0

General Comments

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