INT140288

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Context Info
Confidence 0.78
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 6.15
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pon1) extracellular region (Pon1) lipid metabolic process (Pon1)
Anatomy Link Frequency
liver 1
Pon1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Regional anesthesia 5 98.24 Very High Very High Very High
lidocaine 4 97.08 Very High Very High Very High
Inflammation 62 89.36 High High
ischemia 1 82.16 Quite High
anesthesia 13 55.92 Quite High
chemokine 4 26.36 Quite Low
Inflammatory response 4 12.20 Low Low
cytokine 4 5.12 Low Low
fibrosis 8 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Liver Disease 58 99.84 Very High Very High Very High
Disorder Of Lipid Metabolism 298 99.36 Very High Very High Very High
Hepatotoxicity 8 96.40 Very High Very High Very High
Congenital Anomalies 8 93.16 High High
Stress 82 90.24 High High
Disease 26 89.60 High High
INFLAMMATION 66 89.36 High High
Cirrhosis 68 85.32 High High
Reperfusion Injury 1 82.92 Quite High
Cv Unclassified Under Development 1 82.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, the proportional distribution of phospholipids and apo A-I in HDL has been shown to play an important role in PON1 secretion, stability and activity.
Localization (secretion) of PON1 associated with disorder of lipid metabolism
1) Confidence 0.78 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 0.71 Pain Relevance 0.03
The incubation of HDL with PNGase F strongly suggests that this protein is, indeed, a highly glycosylated form of PON1.
Localization (form) of PON1 associated with disorder of lipid metabolism
2) Confidence 0.73 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 0.77 Pain Relevance 0
Not much is known about the biochemical mechanisms underlying these alterations in PON1 synthesis and secretion in liver diseases.
Localization (secretion) of PON1 in liver associated with liver disease
3) Confidence 0.68 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 1.18 Pain Relevance 0.11
Of special note is the presence of a high molecular weight inactive PON1 carried in the HDL in large quantities.
Localization (presence) of PON1 associated with disorder of lipid metabolism
4) Confidence 0.68 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 1.19 Pain Relevance 0.04
Measurement of paraoxonase and arylesterase activities
Localization (Measurement) of paraoxonase
5) Confidence 0.53 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2845769 Disease Relevance 1.07 Pain Relevance 0.09
Measurement of paraoxonase and arylesterase activities
Localization (arylesterase) of paraoxonase
6) Confidence 0.53 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2845769 Disease Relevance 1.06 Pain Relevance 0.09
Serum levels of malondialdehyde (MDA) and paraoxonase activity were measured at 1 min before, immediately upon, and 30 min after the release of the tourniquet.
Localization (release) of paraoxonase
7) Confidence 0.19 Published 2006 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 17136232 Disease Relevance 0.17 Pain Relevance 0.80

General Comments

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