INT14029

Context Info Confidence 0.19 First Reported 1983 Last Reported 2009 Negated 1 Speculated 1 Reported most in Abstract Documents 9 Total Number 10 Disease Relevance 0.68 Pain Relevance 7.40

oxidoreductase activity (Fdft1) endoplasmic reticulum (Fdft1) transferase activity, transferring alkyl or aryl (other than methyl) groups (Fdft1)

Anatomy Link Frequency spinal 1 neuronal 1 hypothalamus 1 pituitary 1 brains 1 Fdft1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Somatostatin 93 100.00 Calcitonin gene-related peptide 37 100.00 Clonidine 30 100.00 agonist 5 100.00 Glutamate receptor 3 99.76 substance P 33 99.68 dexamethasone 46 98.56 spinal dorsal horn 11 98.48 antagonist 3 96.80 Neuropeptide 16 96.00

Disease Link Frequency Relevance Heat Pain 24 90.76 Neurogenic Inflammation 2 72.24 Urological Neuroanatomy 4 66.80 Nociception 25 56.08 Stress 12 5.00 Polycystic Ovary Syndrome 7 5.00 Hyperalgesia 1 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Previous studies have shown changes in both somatostatin (SS)- and proenkephalin(PE)-derived peptides in the brains of amygdaloid-kindled rats, suggesting possible roles for the peptides in the kindling process.

Regulation (changes) of SS in brains associated with somatostatin

1) Confidence 0.19 Published 1991 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1684628 Disease Relevance 0.07 Pain Relevance 0.24

The effects of bath-applied somatostatin (SS), and related peptides on the membrane potential and input resistance of 117 ventral subicular neurons were investigated by intracellular recording in rat brain slices.

Spec (investigated) Regulation (effects) of SS in ventral associated with somatostatin

2) Confidence 0.14 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8632306 Disease Relevance 0 Pain Relevance 0.22

The effects of MK 678, SS, SS D-Trp8 and somatostatin were concentration-dependent, and these peptides were equipotent at 500 nM and at 5 microM.

Regulation (effects) of SS associated with somatostatin

3) Confidence 0.10 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8632306 Disease Relevance 0 Pain Relevance 0.73

Regulation of somatostatin (SS) secretion was studied in an in vitro system using collagenase-dispersed cells from fetal rat hypothalamus maintained in long term monolayer culture.

Regulation (Regulation) of SS in hypothalamus associated with somatostatin

4) Confidence 0.08 Published 1983 Journal Endocrinology Section Abstract Doc Link 6129132 Disease Relevance 0 Pain Relevance 0.43

The effects of adrenalectomy on CGRP and SS were reversed by administration of dexamethasone.

Regulation (effects) of SS associated with somatostatin, dexamethasone and calcitonin gene-related peptide

5) Confidence 0.08 Published 1991 Journal Brain Res. Section Abstract Doc Link 1723340 Disease Relevance 0.21 Pain Relevance 1.08

The effects of the alpha-2 adrenoceptor agonist clonidine (CLO) on the growth hormone (GH) regulatory neuronal systems, growth hormone-releasing hormone (GHRH) and somatostatin (SS), were studied in adult male rats given a single or a short-term administration (1, 3 and 6 days) of the drug.

Regulation (effects) of SS in neuronal associated with somatostatin, agonist and clonidine

6) Confidence 0.08 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8632352 Disease Relevance 0 Pain Relevance 0.65

Hypothalamic SS content and mRNA levels remained unaltered.

Regulation (unaltered) of SS associated with somatostatin

7) Confidence 0.05 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8632352 Disease Relevance 0 Pain Relevance 1.02

In these rats, pituitary GH content and mRNA levels were also significantly increased, whereas hypothalamic SS content and mRNA levels remained unaltered.

Regulation (unaltered) of SS in pituitary associated with somatostatin

8) Confidence 0.05 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8632352 Disease Relevance 0 Pain Relevance 0.94

The effects of MK 678, SS, SS D-Trp8 and somatostatin were concentration-dependent, and these peptides were equipotent at 500 nM and at 5 microM.

Regulation (effects) of SS associated with somatostatin

9) Confidence 0.04 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8632306 Disease Relevance 0 Pain Relevance 0.73

Contrary to CGRP, SP and GABAB2, no effect of GC was observed on the spinal levels of SS.

Neg (no) Regulation (effect) of SS in spinal associated with somatostatin, substance p and calcitonin gene-related peptide

10) Confidence 0.01 Published 2009 Journal Mol Pain Section Body Doc Link PMC2727498 Disease Relevance 0.41 Pain Relevance 1.36

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