INT14029

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Context Info
Confidence 0.19
First Reported 1983
Last Reported 2009
Negated 1
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 0.68
Pain Relevance 7.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Fdft1) endoplasmic reticulum (Fdft1) transferase activity, transferring alkyl or aryl (other than methyl) groups (Fdft1)
Anatomy Link Frequency
spinal 1
neuronal 1
hypothalamus 1
pituitary 1
brains 1
Fdft1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 93 100.00 Very High Very High Very High
Calcitonin gene-related peptide 37 100.00 Very High Very High Very High
Clonidine 30 100.00 Very High Very High Very High
agonist 5 100.00 Very High Very High Very High
Glutamate receptor 3 99.76 Very High Very High Very High
substance P 33 99.68 Very High Very High Very High
dexamethasone 46 98.56 Very High Very High Very High
spinal dorsal horn 11 98.48 Very High Very High Very High
antagonist 3 96.80 Very High Very High Very High
Neuropeptide 16 96.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 24 90.76 High High
Neurogenic Inflammation 2 72.24 Quite High
Urological Neuroanatomy 4 66.80 Quite High
Nociception 25 56.08 Quite High
Stress 12 5.00 Very Low Very Low Very Low
Polycystic Ovary Syndrome 7 5.00 Very Low Very Low Very Low
Hyperalgesia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous studies have shown changes in both somatostatin (SS)- and proenkephalin(PE)-derived peptides in the brains of amygdaloid-kindled rats, suggesting possible roles for the peptides in the kindling process.
Regulation (changes) of SS in brains associated with somatostatin
1) Confidence 0.19 Published 1991 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1684628 Disease Relevance 0.07 Pain Relevance 0.24
The effects of bath-applied somatostatin (SS), and related peptides on the membrane potential and input resistance of 117 ventral subicular neurons were investigated by intracellular recording in rat brain slices.
Spec (investigated) Regulation (effects) of SS in ventral associated with somatostatin
2) Confidence 0.14 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8632306 Disease Relevance 0 Pain Relevance 0.22
The effects of MK 678, SS, SS D-Trp8 and somatostatin were concentration-dependent, and these peptides were equipotent at 500 nM and at 5 microM.
Regulation (effects) of SS associated with somatostatin
3) Confidence 0.10 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8632306 Disease Relevance 0 Pain Relevance 0.73
Regulation of somatostatin (SS) secretion was studied in an in vitro system using collagenase-dispersed cells from fetal rat hypothalamus maintained in long term monolayer culture.
Regulation (Regulation) of SS in hypothalamus associated with somatostatin
4) Confidence 0.08 Published 1983 Journal Endocrinology Section Abstract Doc Link 6129132 Disease Relevance 0 Pain Relevance 0.43
The effects of adrenalectomy on CGRP and SS were reversed by administration of dexamethasone.
Regulation (effects) of SS associated with somatostatin, dexamethasone and calcitonin gene-related peptide
5) Confidence 0.08 Published 1991 Journal Brain Res. Section Abstract Doc Link 1723340 Disease Relevance 0.21 Pain Relevance 1.08
The effects of the alpha-2 adrenoceptor agonist clonidine (CLO) on the growth hormone (GH) regulatory neuronal systems, growth hormone-releasing hormone (GHRH) and somatostatin (SS), were studied in adult male rats given a single or a short-term administration (1, 3 and 6 days) of the drug.
Regulation (effects) of SS in neuronal associated with somatostatin, agonist and clonidine
6) Confidence 0.08 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8632352 Disease Relevance 0 Pain Relevance 0.65
Hypothalamic SS content and mRNA levels remained unaltered.
Regulation (unaltered) of SS associated with somatostatin
7) Confidence 0.05 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8632352 Disease Relevance 0 Pain Relevance 1.02
In these rats, pituitary GH content and mRNA levels were also significantly increased, whereas hypothalamic SS content and mRNA levels remained unaltered.
Regulation (unaltered) of SS in pituitary associated with somatostatin
8) Confidence 0.05 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8632352 Disease Relevance 0 Pain Relevance 0.94
The effects of MK 678, SS, SS D-Trp8 and somatostatin were concentration-dependent, and these peptides were equipotent at 500 nM and at 5 microM.
Regulation (effects) of SS associated with somatostatin
9) Confidence 0.04 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8632306 Disease Relevance 0 Pain Relevance 0.73
Contrary to CGRP, SP and GABAB2, no effect of GC was observed on the spinal levels of SS.
Neg (no) Regulation (effect) of SS in spinal associated with somatostatin, substance p and calcitonin gene-related peptide
10) Confidence 0.01 Published 2009 Journal Mol Pain Section Body Doc Link PMC2727498 Disease Relevance 0.41 Pain Relevance 1.36

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