INT140296

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 13.61
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (XIAP) intracellular (XIAP) ligase activity (XIAP)
cytoplasm (XIAP)
Anatomy Link Frequency
cleavage 3
XIAP (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 10 99.04 Very High Very High Very High
Analgesic 2 96.16 Very High Very High Very High
chemokine 5 89.72 High High
dexamethasone 3 83.28 Quite High
Inflammatory mediators 2 81.68 Quite High
cINOD 9 75.68 Quite High
agonist 44 50.00 Quite Low
headache 6 37.76 Quite Low
antagonist 2 6.40 Low Low
Inflammation 25 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 138 100.00 Very High Very High Very High
Targeted Disruption 17 99.42 Very High Very High Very High
Cancer 488 99.00 Very High Very High Very High
Glioblastoma 19 98.86 Very High Very High Very High
Melanoma 146 98.48 Very High Very High Very High
Hepatotoxicity 6 98.48 Very High Very High Very High
Ovarian Cancer 25 95.68 Very High Very High Very High
Basal Cell Neoplasms 5 92.60 High High
Injury 9 91.60 High High
Multiple Myeloma 61 90.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bcl-2 cleavage and down-regulation of the inhibitor of apoptosis proteins (IAPs) family including cIAP-1/2, XIAP, and survivin, occurred downstream of ROS production during sulindac-induced apoptosis.
Negative_regulation (down-regulation) of XIAP in cleavage associated with apoptosis
1) Confidence 0.45 Published 2007 Journal Apoptosis Section Abstract Doc Link 17136320 Disease Relevance 1.32 Pain Relevance 0.08
Apoptosis was associated with the downregulation of anti-apoptotic proteins XIAP and Mcl-1 as well as induction of caspase-3 activity [207].
Negative_regulation (downregulation) of XIAP associated with apoptosis
2) Confidence 0.42 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 1.49 Pain Relevance 0.04
Bcl-2 cleavage and down-regulation of the inhibitor of apoptosis proteins (IAPs) family including cIAP-1/2, XIAP, and survivin, occurred downstream of ROS production during sulindac-induced apoptosis.
Negative_regulation (inhibitor) of XIAP in cleavage associated with apoptosis
3) Confidence 0.33 Published 2007 Journal Apoptosis Section Abstract Doc Link 17136320 Disease Relevance 1.32 Pain Relevance 0.07
Most human cancers have high levels of IAPs, including the X-linked inhibitor of apoptosis protein (XIAP) isoform, which are associated with poor treatment responses [83].
Negative_regulation (inhibitor) of XIAP associated with cancer and apoptosis
4) Confidence 0.32 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC2958340 Disease Relevance 1.26 Pain Relevance 0
Most human cancers have high levels of IAPs, including the X-linked inhibitor of apoptosis protein (XIAP) isoform, which are associated with poor treatment responses [83].
Negative_regulation (inhibitor) of apoptosis protein associated with cancer and apoptosis
5) Confidence 0.32 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC2958340 Disease Relevance 1.26 Pain Relevance 0
The X-linked inhibitor of apoptosis protein (XIAP) is up-regulated in metastatic melanoma, and XIAP cleavage by Phenoxodiol is associated with Carboplatin sensitization

XIAP up-regulation is associated with chemotherapy resistance.

Negative_regulation (inhibitor) of apoptosis protein in cleavage associated with melanoma and apoptosis
6) Confidence 0.29 Published 2007 Journal J Transl Med Section Title Doc Link PMC1796544 Disease Relevance 0.98 Pain Relevance 0
The two pathways are inhibited by a group of proteins called the IAP (inhibitors of apoptosis) proteins, of which the X-linked inhibitor of apoptosis protein (XIAP) is a key member.
Negative_regulation (inhibitor) of apoptosis protein associated with apoptosis
7) Confidence 0.29 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 0.97 Pain Relevance 0
Based on these observations, Vellanki et al. found that the inherent radioresistance of glioblastoma CSCs could be alleviated by promoting apoptosis with an XIAP inhibitor.
Negative_regulation (inhibitor) of XIAP associated with glioblastoma and apoptosis
8) Confidence 0.27 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC2958340 Disease Relevance 1.33 Pain Relevance 0
Survivin is a member of the inhibitor of apoptosis protein (IAP) family, and has generated interest because of its increased expression in many human cancer cell lines [19].
Negative_regulation (inhibitor) of apoptosis protein associated with cancer and apoptosis
9) Confidence 0.04 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2647552 Disease Relevance 1.13 Pain Relevance 0
CXC receptor-2 knockout genotype increases X-linked inhibitor of apoptosis protein and protects mice from acetaminophen hepatotoxicity.
Negative_regulation (inhibitor) of apoptosis protein associated with targeted disruption, paracetamol, hepatotoxicity and apoptosis
10) Confidence 0.00 Published 2010 Journal Hepatology Section Title Doc Link 20683965 Disease Relevance 1.15 Pain Relevance 0.67
Conclusion: The decreased rate of apoptosis in the knockout mice correlated with an almost undetectable and significantly decreased level of activated caspase-3 and significantly increased levels of X-linked inhibitor of apoptosis protein, which also correlated with increased levels of nuclear factor kappa B p52 and decreased levels of c-Jun N-terminal kinase; this provides a possible mechanism for the decrease in apoptosis seen in CXCR2 knockout mice.
Negative_regulation (inhibitor) of apoptosis protein associated with targeted disruption and apoptosis
11) Confidence 0.00 Published 2010 Journal Hepatology Section Abstract Doc Link 20683965 Disease Relevance 1.41 Pain Relevance 0.50

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