INT14030

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Context Info
Confidence 0.47
First Reported 1990
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 7
Total Number 9
Disease Relevance 5.58
Pain Relevance 2.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Npy) extracellular region (Npy)
Anatomy Link Frequency
neurons 4
hippocampus 4
mossy fibers 2
adult mouse 2
Npy (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 36 100.00 Very High Very High Very High
Enkephalin 9 100.00 Very High Very High Very High
Dynorphin 4 100.00 Very High Very High Very High
Cholecystokinin 2 100.00 Very High Very High Very High
Hippocampus 27 99.84 Very High Very High Very High
Opioid 2 93.48 High High
projection neuron 1 91.96 High High
Thalamus 2 89.44 High High
Pyramidal cell 2 79.28 Quite High
anesthesia 2 77.00 Quite High
Disease Link Frequency Relevance Heat
Convulsion 63 100.00 Very High Very High Very High
Diabetes Mellitus 38 100.00 Very High Very High Very High
Appetite Loss 4 100.00 Very High Very High Very High
Sprains And Strains 4 99.20 Very High Very High Very High
Death 10 92.68 High High
Apoptosis 16 92.64 High High
Starvation 46 89.68 High High
Neurodegenerative Disease 32 87.08 High High
Scrapie 3 84.00 Quite High
Hyperphagia 17 83.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In adult mouse hypothalami, the expression of landmark genes such as Npy, Pomc1 and Agrp is changed upon food deprivation [16].
Regulation (changed) of Gene_expression (expression) of Npy in adult mouse
1) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827556 Disease Relevance 0 Pain Relevance 0
Moreover, ectopic NPY expression in mossy fibers was readily detected in 3 out of 4 saline-treated SurvivinCamcre mice but not in any of the corresponding controls (n = 5) (Figure 6C, D).
Neg (not) Regulation (detected) of Gene_expression (expression) of NPY in mossy fibers
2) Confidence 0.35 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0.57 Pain Relevance 0.13
Hypothalamic expression levels of peptides known to be involved in appetite regulation, such as NPY, POMC, and AGRP, are changed upon food deprivation, and neurons expressing these molecules are essential components in the control of energy homeostasis [8].
Regulation (changed) of Gene_expression (expression) of NPY in neurons associated with appetite loss
3) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827556 Disease Relevance 1.42 Pain Relevance 0
In addition, these METH injections were associated with increased expression of neuropeptide Y mRNA and changes in the expression of the NPY receptors Y1 and Y2.
Regulation (changes) of Gene_expression (expression) of NPY associated with neuropeptide
4) Confidence 0.27 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15930374 Disease Relevance 0.67 Pain Relevance 0.41
Between 110 and 140 days postinoculation NPY mRNA expression was specifically up-regulated in CA3 pyramidal neurones, whereas expression of NPY in hilar neurones remained unaltered.
Regulation (unaltered) of Gene_expression (expression) of NPY
5) Confidence 0.27 Published 1996 Journal Neuroreport Section Abstract Doc Link 8905686 Disease Relevance 0.32 Pain Relevance 0.37
A study of 5 neuropeptides in 5 strains of mice has identified neuropeptide Y (NPY) as a gene whose expression in the hypothalamus is controlled by nutritional status, suggesting that hypothalamic NPY neurons are a link in the neural network regulating feeding behavior and energy metabolism.
Regulation (controlled) of Gene_expression (expression) of NPY in neurons associated with neuropeptide and sprains and strains
6) Confidence 0.27 Published 1991 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1684630 Disease Relevance 0.33 Pain Relevance 0.30
Recurrent seizures induce two temporally distinct changes in NPY expression in hippocampus.
Regulation (changes) of Gene_expression (expression) of NPY in hippocampus associated with convulsion and hippocampus
7) Confidence 0.22 Published 1990 Journal Prog. Brain Res. Section Abstract Doc Link 2203104 Disease Relevance 0.76 Pain Relevance 0.67
In studies described here, we examined the influence of recurrent limbic seizures on the expression of enkephalin, dynorphin, cholecystokinin, and neuropeptide Y (NPY) in rat and mouse hippocampus using immunohistochemical, in situ hybridization and blot hybridization techniques.
Spec (examined) Regulation (influence) of Gene_expression (expression) of NPY in hippocampus associated with convulsion, dynorphin, neuropeptide, hippocampus, enkephalin and cholecystokinin
8) Confidence 0.22 Published 1990 Journal Prog. Brain Res. Section Abstract Doc Link 2203104 Disease Relevance 0.50 Pain Relevance 0.61
Adrenalectomy blocked the effects of fasting and diabetes on hypothalamic AGRP, NPY, and POMC expression.
Regulation (effects) of Gene_expression (expression) of NPY associated with diabetes mellitus
9) Confidence 0.20 Published 2003 Journal BMC Physiol Section Abstract Doc Link PMC179893 Disease Relevance 1.00 Pain Relevance 0

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