INT140305

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Context Info
Confidence 0.21
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.54
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Drd1a) endoplasmic reticulum (Drd1a) plasma membrane (Drd1a)
nucleus (Drd1a) intracellular (Drd1a) signal transducer activity (Drd1a)
Anatomy Link Frequency
brain 2
nucleus 2
Drd1a (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 31 99.98 Very High Very High Very High
Ventral tegmentum 4 98.80 Very High Very High Very High
Nucleus accumbens 11 97.84 Very High Very High Very High
dopamine receptor 9 97.60 Very High Very High Very High
antagonist 4 96.88 Very High Very High Very High
opioid receptor 3 94.80 High High
gABA 4 89.92 High High
GABAergic 2 87.04 High High
Catecholamine 8 83.96 Quite High
Neurotransmitter 10 77.76 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 5 99.60 Very High Very High Very High
Sprains And Strains 114 67.56 Quite High
Disease 8 41.76 Quite Low
Schizophrenia 2 40.40 Quite Low
Eating Disorder 2 39.20 Quite Low
Manic Depressive Disorder 2 37.76 Quite Low
Anxiety Disorder 2 36.32 Quite Low
Drug Dependence 2 35.28 Quite Low
Cognitive Disorder 12 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As expected, dopaminergic systems are clearly downstream of Comt, including Maoa in the striatum, DRD1 and DRD2 binding density in multiple brain regions, and the response to the dopamine receptor antagonist haloperidol.
Negative_regulation (downstream) of DRD1 Binding (binding) of in brain associated with antagonist and dopamine receptor
1) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.07 Pain Relevance 0.45
Linkage of DRD1 and DRD2 binding was sex-specific and only detected in males.
Negative_regulation (detected) of DRD1 Binding (Linkage) of
2) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.12 Pain Relevance 0.38
After repeated METH exposure, striatal and nucleus accumbal dopamine D1 receptor binding was decreased in mu-OR knockout mice but was not changed in wild-type mice.
Negative_regulation (decreased) of D1 receptor Binding (binding) of in nucleus associated with targeted disruption and dopamine
3) Confidence 0.19 Published 2007 Journal J. Neurosci. Res. Section Abstract Doc Link 17139685 Disease Relevance 0.36 Pain Relevance 0.64

General Comments

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