INT140306

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Context Info
Confidence 0.20
First Reported 2007
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.36
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Drd1a) endoplasmic reticulum (Drd1a) plasma membrane (Drd1a)
nucleus (Drd1a) intracellular (Drd1a) signal transducer activity (Drd1a)
Anatomy Link Frequency
nucleus 2
Drd1a (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 1 99.98 Very High Very High Very High
opioid receptor 3 94.80 High High
dopamine receptor 3 75.00 Quite High
Opioid 2 75.00 Quite High
Endogenous opioid 2 73.92 Quite High
Nucleus accumbens 1 65.36 Quite High
Enkephalin 2 61.72 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 5 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After repeated METH exposure, striatal and nucleus accumbal dopamine D1 receptor binding was decreased in mu-OR knockout mice but was not changed in wild-type mice.
Neg (not) Regulation (changed) of D1 receptor Binding (binding) of in nucleus associated with targeted disruption and dopamine
1) Confidence 0.20 Published 2007 Journal J. Neurosci. Res. Section Abstract Doc Link 17139685 Disease Relevance 0.36 Pain Relevance 0.64

General Comments

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