INT14031

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Context Info
Confidence 0.78
First Reported 1990
Last Reported 2010
Negated 4
Speculated 3
Reported most in Abstract
Documents 107
Total Number 112
Disease Relevance 36.48
Pain Relevance 35.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Npy) extracellular region (Npy)
Anatomy Link Frequency
neurons 16
arcuate nucleus 11
brain 7
hypothalamus 6
mossy fibers 5
Npy (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 392 100.00 Very High Very High Very High
gABA 220 100.00 Very High Very High Very High
Cholecystokinin 176 100.00 Very High Very High Very High
Enkephalin 126 100.00 Very High Very High Very High
Neurotransmitter 84 100.00 Very High Very High Very High
Endocannabinoid 35 100.00 Very High Very High Very High
Dynorphin 29 100.00 Very High Very High Very High
interneuron 12 100.00 Very High Very High Very High
Dorsal horn neuron 9 99.96 Very High Very High Very High
Somatostatin 197 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 300 100.00 Very High Very High Very High
Appetite Loss 188 100.00 Very High Very High Very High
Obesity 1046 99.98 Very High Very High Very High
Convulsion 419 99.92 Very High Very High Very High
Injury 30 99.92 Very High Very High Very High
Sleep Disorders 75 99.72 Very High Very High Very High
Aids-related Complex 59 99.68 Very High Very High Very High
Repression 14 99.66 Very High Very High Very High
Diabetes Mellitus 95 99.54 Very High Very High Very High
Cancer 17 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, these METH injections were associated with increased expression of neuropeptide Y mRNA and changes in the expression of the NPY receptors Y1 and Y2.
Gene_expression (expression) of NPY associated with neuropeptide
1) Confidence 0.78 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15930374 Disease Relevance 0.67 Pain Relevance 0.41
Between 110 and 140 days postinoculation NPY mRNA expression was specifically up-regulated in CA3 pyramidal neurones, whereas expression of NPY in hilar neurones remained unaltered.
Gene_expression (expression) of NPY mRNA
2) Confidence 0.78 Published 1996 Journal Neuroreport Section Abstract Doc Link 8905686 Disease Relevance 0.31 Pain Relevance 0.36
Expression of NPY and NPY receptors is changed in the hippocampus of mice comparatively early after prion inoculation, indicating that this peptide system is affected in this spongiform degenerative disease in a region of importance for learning and memory.
Gene_expression (Expression) of NPY in hippocampus associated with hippocampus and disease
3) Confidence 0.77 Published 1999 Journal Horm. Metab. Res. Section Abstract Doc Link 10422730 Disease Relevance 0.43 Pain Relevance 0.45
Expression of NPY and NPY receptors is changed in the hippocampus of mice comparatively early after prion inoculation, indicating that this peptide system is affected in this spongiform degenerative disease in a region of importance for learning and memory.
Gene_expression (Expression) of NPY in hippocampus associated with hippocampus and disease
4) Confidence 0.77 Published 1999 Journal Horm. Metab. Res. Section Abstract Doc Link 10422730 Disease Relevance 0.43 Pain Relevance 0.46
Our findings suggest that abnormal NPY and enkephalin gene expression in the hypothalamus may be two important determinants of the expression of the diabetes mutation.
Gene_expression (expression) of NPY in hypothalamus associated with diabetes mellitus and enkephalin
5) Confidence 0.77 Published 1991 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1684630 Disease Relevance 0.43 Pain Relevance 0.31
Neuropeptide Y (NPY) was hardly detectable in our cultures (data not shown).


Gene_expression (detectable) of NPY associated with neuropeptide
6) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722079 Disease Relevance 0 Pain Relevance 0.31
Proenkephalin mRNA in both saline- and ACTH-treated CRHR1 null mice were higher than in control animals (215.8% P <0.05, 268.9% P <0.01) whereas expression of neuropeptide Y and chromogranin B did not differ.
Gene_expression (expression) of neuropeptide Y associated with neuropeptide
7) Confidence 0.75 Published 2002 Journal Mol. Psychiatry Section Abstract Doc Link 12399950 Disease Relevance 0.11 Pain Relevance 0.22
These results suggest that the synthesis of NPY, ENK and NT is enhanced in TIDA neurons during lactation and that these neuromessengers may be co-released together with DA from the ME to regulate the suckling-induced prolactin secretion at the hypothalamic and/or pituitary levels.
Gene_expression (synthesis) of NPY in neurons associated with enkephalin
8) Confidence 0.75 Published 1993 Journal J. Neuroendocrinol. Section Abstract Doc Link 8680430 Disease Relevance 0.09 Pain Relevance 0.63
Results demonstrated three features with regard to the selective roles of PC2 in determining the production of NPY, somatostatin-28, enkephalin, VIP, galanin, and CRF in neuroendocrine tissues.
Gene_expression (production) of NPY associated with somatostatin and enkephalin
9) Confidence 0.72 Published 2003 Journal Neuropeptides Section Abstract Doc Link 12860111 Disease Relevance 0 Pain Relevance 0.71
Our results suggest that the up-regulated expression of neuropeptide Y mRNA might contribute to the increased weights of adult mu-opioid receptor knockout mice.
Gene_expression (expression) of neuropeptide Y mRNA associated with targeted disruption, neuropeptide and opioid receptor
10) Confidence 0.69 Published 2006 Journal Neuroreport Section Abstract Doc Link 16738492 Disease Relevance 0.61 Pain Relevance 0.34
Here we report that mice lacking the NPY gene show normal conditioned place aversion to opiate withdrawal, but show attenuated opiate withdrawal somatic signs.
Neg (lacking) Gene_expression (lacking) of NPY gene associated with opiate and withdrawal
11) Confidence 0.68 Published 2006 Journal Synapse Section Abstract Doc Link 16952158 Disease Relevance 0 Pain Relevance 0.64
Assay of NPY
Gene_expression (Assay) of NPY
12) Confidence 0.66 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC3024290 Disease Relevance 0.43 Pain Relevance 0.21
First, we analyzed POMC, AgRP and NPY mRNAs levels in these clamped mice (figure 2B) and observed a significant 3 fold increase in POMC mRNA levels and a 2.3 and 1.6 fold decrease respectively in AgRP and NPY mRNA levels in the eGHI mice compared to the control mice (figure 2B).
Spec (analyzed) Gene_expression (levels) of NPY
13) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0.05 Pain Relevance 0
CGRP and ANP mRNAs did not change across the estrous cycle, while expression of galanin and NPY mRNAs were strongly linked to the estrous cycle.
Gene_expression (expression) of NPY
14) Confidence 0.65 Published 2005 Journal Neuropeptides Section Abstract Doc Link 15936815 Disease Relevance 0.49 Pain Relevance 0.63
NPY was absent in controls but was expressed in A-fiber neurons after CCI.
Neg (absent) Gene_expression (absent) of NPY in neurons associated with eae
15) Confidence 0.65 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17348016 Disease Relevance 0.92 Pain Relevance 1.55
NPY was absent in controls but was expressed in A-fiber neurons after CCI.
Neg (absent) Gene_expression (expressed) of NPY in neurons associated with eae
16) Confidence 0.65 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17348016 Disease Relevance 0.92 Pain Relevance 1.56
For example, NPY levels were decreased in ileum of PC2 deficient mice, but NPY content was not altered in hypothalamus that is abundant in NPY.
Gene_expression (abundant) of NPY in hypothalamus
17) Confidence 0.62 Published 2003 Journal Neuropeptides Section Abstract Doc Link 12860111 Disease Relevance 0 Pain Relevance 0.89
Interestingly, expression of the orexigenic acting NPY in the hypothalamic arcuate nucleus was reduced in Dyn(-/-) mice.
Gene_expression (expression) of NPY in arcuate nucleus
18) Confidence 0.60 Published 2007 Journal Mol. Endocrinol. Section Abstract Doc Link 17456788 Disease Relevance 0.43 Pain Relevance 0.20
In addition, these METH injections were associated with increased expression of neuropeptide Y mRNA and changes in the expression of the NPY receptors Y1 and Y2.
Gene_expression (expression) of neuropeptide Y mRNA associated with neuropeptide
19) Confidence 0.60 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15930374 Disease Relevance 0.67 Pain Relevance 0.41
Here we examined, using in situ hybridization histochemistry, the expression of neuropeptide Y (NPY), an inducible and abundant neuropeptide in mammalian brain with known neuroregulatory functions, and glial fibrillary acidic protein (GFAP), a marker for astroglial activation, in the hippocampus at different time points following intracerebral prion inoculation in male CD-1 mice.
Gene_expression (expression) of neuropeptide Y in brain associated with neuropeptide and hippocampus
20) Confidence 0.60 Published 1996 Journal Neuroreport Section Abstract Doc Link 8905686 Disease Relevance 0.27 Pain Relevance 0.33

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