INT14032

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Context Info
Confidence 0.43
First Reported 1991
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 1.48
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Npy) extracellular region (Npy)
Anatomy Link Frequency
arcuate nucleus 4
hypothalamus 2
Npy (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 8 100.00 Very High Very High Very High
Somatostatin 6 99.92 Very High Very High Very High
Neuropeptide 25 96.72 Very High Very High Very High
Dynorphin 4 83.12 Quite High
Neurotransmitter 6 81.56 Quite High
cocaine 3 80.88 Quite High
Kinase C 1 80.32 Quite High
Central nervous system 18 78.96 Quite High
Endogenous opioid 3 54.00 Quite High
agonist 20 51.04 Quite High
Disease Link Frequency Relevance Heat
Repression 2 100.00 Very High Very High Very High
Diabetes Mellitus 6 98.96 Very High Very High Very High
Stress 15 94.56 High High
Targeted Disruption 10 83.48 Quite High
Sprains And Strains 8 83.36 Quite High
Eating Disorder 1 76.24 Quite High
Weight Loss 3 75.00 Quite High
Body Weight 10 68.76 Quite High
Hypoglycemia 3 59.20 Quite High
Obesity 68 54.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, expression of the orexigenic acting NPY in the hypothalamic arcuate nucleus was reduced in Dyn(-/-) mice.
Negative_regulation (reduced) of Gene_expression (expression) of NPY in arcuate nucleus
1) Confidence 0.43 Published 2007 Journal Mol. Endocrinol. Section Abstract Doc Link 17456788 Disease Relevance 0.43 Pain Relevance 0.20
Our findings suggest that abnormal NPY and enkephalin gene expression in the hypothalamus may be two important determinants of the expression of the diabetes mutation.
Spec (determinants) Negative_regulation (determinants) of Gene_expression (expression) of NPY in hypothalamus associated with diabetes mellitus and enkephalin
2) Confidence 0.42 Published 1991 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1684630 Disease Relevance 0.43 Pain Relevance 0.31
Results demonstrated three features with regard to the selective roles of PC2 in determining the production of NPY, somatostatin-28, enkephalin, VIP, galanin, and CRF in neuroendocrine tissues.
Spec (determining) Negative_regulation (determining) of Gene_expression (production) of NPY associated with somatostatin and enkephalin
3) Confidence 0.39 Published 2003 Journal Neuropeptides Section Abstract Doc Link 12860111 Disease Relevance 0 Pain Relevance 0.71
Based on the published data cited above, we would have expected to see increased Npy and decreased Crh expression in the hypothalami of deprived pups.
Negative_regulation (decreased) of Gene_expression (expression) of Npy
4) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827556 Disease Relevance 0.23 Pain Relevance 0.03
POMC/CART and NPY/AgRP neuronal pathways from the arcuate nucleus
Negative_regulation (/) of Gene_expression (neuronal) of NPY in arcuate nucleus
5) Confidence 0.27 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.13 Pain Relevance 0.11
Upon binding to its receptor in the ARH, insulin triggers a repression of the AgRP and NPY gene expression and an increase in POMC gene expression [26], [42].
Negative_regulation (repression) of Gene_expression (expression) of NPY gene associated with repression
6) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0.27 Pain Relevance 0.11

General Comments

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