INT14033

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Context Info
Confidence 0.33
First Reported 1980
Last Reported 2007
Negated 1
Speculated 2
Reported most in Abstract
Documents 10
Total Number 12
Disease Relevance 3.47
Pain Relevance 8.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpe) extracellular space (Cpe) extracellular region (Cpe)
Golgi apparatus (Cpe)
Anatomy Link Frequency
neuronal 2
hypothalamus 2
neurons 2
striatum 2
vas deferens 2
Cpe (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 62 100.00 Very High Very High Very High
substance P 12 100.00 Very High Very High Very High
Dynorphin 4 100.00 Very High Very High Very High
Somatostatin 4 100.00 Very High Very High Very High
GABA receptor 1 99.84 Very High Very High Very High
Dopamine 19 99.60 Very High Very High Very High
Hippocampus 1 99.56 Very High Very High Very High
cerebral cortex 2 98.92 Very High Very High Very High
antagonist 6 98.84 Very High Very High Very High
gABA 4 98.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sprains And Strains 6 99.90 Very High Very High Very High
Targeted Disruption 22 99.30 Very High Very High Very High
Diabetes Mellitus 3 98.96 Very High Very High Very High
Disease 11 97.00 Very High Very High Very High
Aids-related Complex 1 94.00 High High
Parkinson's Disease 2 86.60 High High
Depression 1 83.32 Quite High
Body Weight 1 81.68 Quite High
Alcohol Addiction 1 78.20 Quite High
Drug Dependence 1 66.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the ethanol-treated group, there was a significant (P<0.05) reduction of the levels of Met-enkephalin in serum to 70.5% of control levels.
Negative_regulation (reduction) of Gene_expression (levels) of Met-enkephalin associated with enkephalin
1) Confidence 0.33 Published 2006 Journal Peptides Section Abstract Doc Link 16672169 Disease Relevance 0.14 Pain Relevance 0.78
To address this issue we examined operant responding for palatable food reinforcers in mice lacking the expression of beta-endorphin, enkephalin or both peptides congenic to two different genetic backgrounds; C57BL/6J and DBA/2J.
Negative_regulation (lacking) of Neg (lacking) Gene_expression (expression) of enkephalin associated with enkephalin
2) Confidence 0.22 Published 2007 Journal Neuroscience Section Abstract Doc Link 17049174 Disease Relevance 0.17 Pain Relevance 0.51
Enkephalin biosynthesis and release in mouse striatum are inhibited by GABA receptor stimulation: compared changes in preproenkephalin mRNA and Tyr-Gly-Gly levels.
Negative_regulation (inhibited) of Gene_expression (biosynthesis) of Enkephalin in striatum associated with gaba receptor and enkephalin
3) Confidence 0.14 Published 1990 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 2170800 Disease Relevance 0 Pain Relevance 0.87
Both transgenic and knock-in mice, however, showed a marked decrease in the level of expression of enkephalin mRNA in striatal neurons without significant decreases in mRNAs encoding substance P, GAD65, or GAD67.
Negative_regulation (decrease) of Gene_expression (expression) of enkephalin in neurons associated with targeted disruption, enkephalin and substance p
4) Confidence 0.13 Published 2000 Journal Exp. Neurol. Section Abstract Doc Link 10739639 Disease Relevance 0.82 Pain Relevance 0.60
The data indicate that decreased expression of enkephalin mRNA may be an early sign of neuronal dysfunction due to the Huntington's disease mutation.
Negative_regulation (decreased) of Gene_expression (expression) of enkephalin in neuronal associated with enkephalin and disease
5) Confidence 0.13 Published 2000 Journal Exp. Neurol. Section Abstract Doc Link 10739639 Disease Relevance 0.85 Pain Relevance 0.56
To test whether endogenous opioid peptides are necessary for the rewarding effects of ethanol, we examined operant oral self-administration of ethanol in mice congenic to the C57BL/6J strain but lacking expression of beta-endorphin, enkephalin or both peptides.
Negative_regulation (lacking) of Gene_expression (expression) of enkephalin associated with endogenous opioid, enkephalin and sprains and strains
6) Confidence 0.09 Published 2004 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 15388297 Disease Relevance 0.18 Pain Relevance 0.27
Our findings suggest that abnormal NPY and enkephalin gene expression in the hypothalamus may be two important determinants of the expression of the diabetes mutation.
Spec (determinants) Negative_regulation (determinants) of Gene_expression (expression) of enkephalin gene in hypothalamus associated with diabetes mellitus and enkephalin
7) Confidence 0.09 Published 1991 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1684630 Disease Relevance 0.43 Pain Relevance 0.31
Results demonstrated three features with regard to the selective roles of PC2 in determining the production of NPY, somatostatin-28, enkephalin, VIP, galanin, and CRF in neuroendocrine tissues.
Spec (determining) Negative_regulation (determining) of Gene_expression (production) of enkephalin associated with somatostatin and enkephalin
8) Confidence 0.06 Published 2003 Journal Neuropeptides Section Abstract Doc Link 12860111 Disease Relevance 0 Pain Relevance 0.72
D1(-/-)D3(-/-) mice evidenced decreased dynorphin and substance P but normal enkephalin expression, whereas dopamine D2-like and GABA(A) receptor binding were increased.
Negative_regulation (decreased) of Gene_expression (expression) of enkephalin associated with gaba, dopamine, dynorphin, enkephalin and substance p
9) Confidence 0.06 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12860471 Disease Relevance 0.31 Pain Relevance 1.45
Striatal expression of substance P and enkephalin mRNAs was reduced by about 50% and 30%, respectively, whereas the expression of GAD67 and GAD65 mRNAs was slightly increased and unaltered, respectively.
Negative_regulation (reduced) of Gene_expression (expression) of enkephalin associated with enkephalin and substance p
10) Confidence 0.06 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11432985 Disease Relevance 0.09 Pain Relevance 0.65
In addition, the level of expression of enkephalin and substance P, which were altered in D2R-/-, were also reestablished to normal levels after A2AR antagonist treatment.
Negative_regulation (reestablished) of Gene_expression (expression) of enkephalin associated with antagonist, enkephalin and substance p
11) Confidence 0.04 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10908627 Disease Relevance 0.39 Pain Relevance 0.62
In contrast, MIF-I had no effect on the inhibition of the stimulated mouse vas deferens produced by Leu-enkephalin.
Negative_regulation (inhibition) of Gene_expression (produced) of Leu-enkephalin in vas deferens associated with enkephalin
12) Confidence 0.01 Published 1980 Journal Peptides Section Abstract Doc Link 6117839 Disease Relevance 0.08 Pain Relevance 0.87

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