INT140338

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.46
First Reported 2005
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 34
Total Number 35
Disease Relevance 23.82
Pain Relevance 9.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il17a) extracellular region (Il17a)
Anatomy Link Frequency
T cells 14
Th17 cells 6
osteoclast 2
CII 2
optic nerve 2
Il17a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 560 100.00 Very High Very High Very High
Inflammation 413 100.00 Very High Very High Very High
abatacept 16 99.98 Very High Very High Very High
Arthritis 582 99.80 Very High Very High Very High
rheumatoid arthritis 517 99.62 Very High Very High Very High
Inflammatory stimuli 8 98.76 Very High Very High Very High
Osteoarthritis 27 97.92 Very High Very High Very High
addiction 5 97.64 Very High Very High Very High
chemokine 83 90.32 High High
Angina 8 90.08 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 459 100.00 Very High Very High Very High
Arthropathy 10 100.00 Very High Very High Very High
Helminth Infection 4 99.88 Very High Very High Very High
Arthritis 579 99.80 Very High Very High Very High
Rheumatoid Arthritis 580 99.62 Very High Very High Very High
Infection 415 99.52 Very High Very High Very High
Sprains And Strains 283 99.12 Very High Very High Very High
Disease 446 99.00 Very High Very High Very High
Multiple Sclerosis 253 98.96 Very High Very High Very High
Immunization 92 98.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the mouse, differentiated Th17 cells responded rapidly in vitro to IL-12, by upregulating the expression of IFN-gamma and downregulating IL-17 expression.
Negative_regulation (downregulating) of Gene_expression (expression) of IL-17 in Th17 cells
1) Confidence 0.46 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 0.37 Pain Relevance 0.16
The actual numbers of IL-17A producing cells in these two T cell populations were extrapolated.
Negative_regulation (numbers) of Gene_expression (producing) of IL-17A in T cell
2) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.60 Pain Relevance 0
We demonstrate the kinetics of IL-17A production in lavage fluids of infected lungs and identify the IL-17A-producing lymphocytes as pulmonary ??
Negative_regulation (kinetics) of Gene_expression (production) of IL-17A in lymphocytes
3) Confidence 0.39 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2887844 Disease Relevance 1.26 Pain Relevance 0
Production of IL-17A in the lungs following intranasal infection with LVS
Negative_regulation (following) of Gene_expression (Production) of IL-17A in lungs associated with sprains and strains and infection
4) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.30 Pain Relevance 0.18
Concentrations of IL-4 protein in the optic nerve declined slightly in 19 days. mRNA expression of IL-17, IFN-gamma and IL-4 was consistent with their protein expression.
Negative_regulation (declined) of Gene_expression (expression) of IL-17 in optic nerve
5) Confidence 0.38 Published 2010 Journal Int. J. Mol. Med. Section Abstract Doc Link 20428790 Disease Relevance 0.80 Pain Relevance 0.37
Weinstock JV reported that helminth infection down-regulates IL-17 production by lamina propria mononuclear cells (LPMCs) and mesenteric lymph node cells at 2 weeks PI [21].
Negative_regulation (regulates) of Gene_expression (production) of IL-17 in mononuclear cells associated with helminth infection
6) Confidence 0.37 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2786920 Disease Relevance 0.56 Pain Relevance 0.09
and IL-17A production were markedly inhibited by treatment with anti–IL-6R mAb (Fig. 3 D).
Negative_regulation (inhibited) of Gene_expression (production) of IL-17A
7) Confidence 0.35 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2373835 Disease Relevance 0.22 Pain Relevance 0.03
Apart from regulation of Th17 cells in experimental mouse models for arthritis, Colin et al. showed modulatory effects of 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) on the memory Th17 activity in untreated early RA patients [14]. 1,25-(OH)2D3 reduced the levels of IL-17A and IFN-gamma and increased IL-4 in stimulated PBMC from treatment-naïve early RA patients [14].
Negative_regulation (reduced) of Gene_expression (levels) of IL-17A in Th17 cells associated with rheumatoid arthritis and arthritis
8) Confidence 0.34 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 0.91 Pain Relevance 0.52
The observed increase in expression levels of IL17A, IL17F, IL22 and IL26 and the downstream proinflammatory cytokines IL6 and IL1?
Negative_regulation (levels) of Gene_expression (expression) of IL17A associated with cytokine
9) Confidence 0.30 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 0.90 Pain Relevance 0.44
Since a previous study showed that IL-10 plays a crucial role in the vitamin D3-mediated inhibition of EAE [32], we further assessed the role of IL-10 on the inhibition of IL-17 production by 1,25(OH)2D3 in activated T cells upon stimulation with TGF-?
Negative_regulation (inhibition) of Gene_expression (production) of IL-17 in T cells associated with multiple sclerosis
10) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.10 Pain Relevance 0
Both SHED and BMMSC transplantations showed no significant changes in the level of IL10 and IL6 in MRL/lpr mice (Figures 5D and 5E); however, SHED transplantation provided a remarkable reduction of TH17 cells and IL17 level in MRL/lpr mice when compared to BMMSC transplantation (Figures 5C and 5F).
Negative_regulation (reduction) of Gene_expression (level) of IL17
11) Confidence 0.26 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 0.66 Pain Relevance 0.11
Furthermore, abatacept suppressed the production of inflammatory cytokines, such as IFN-gamma and IL-17.
Negative_regulation (suppressed) of Gene_expression (production) of IL-17 associated with inflammation, abatacept and cytokine
12) Confidence 0.24 Published 2010 Journal J. Immunol. Section Abstract Doc Link 20601593 Disease Relevance 0.59 Pain Relevance 0.78
Significantly decreased production of the proinflammatory cytokines IFN-gamma and IL-17 is observed in prostate-draining lymph node T cells from Elocalcitol-treated NOD mice stimulated by TCR ligation.
Negative_regulation (decreased) of Gene_expression (production) of IL-17 in T cells associated with diabetes mellitus and cytokine
13) Confidence 0.24 Published 2006 Journal J. Immunol. Section Abstract Doc Link 17142748 Disease Relevance 1.07 Pain Relevance 0.35
Upon B:9-23/IFA immunisation, we observed neither strong induction nor significant reduction of IL-17 production.
Negative_regulation (reduction) of Gene_expression (production) of IL-17 associated with immunization
14) Confidence 0.23 Published 2010 Journal Diabetologia Section Body Doc Link PMC2910887 Disease Relevance 0.61 Pain Relevance 0.14
blockade would result in reduced IL-17 expression, and to test this hypothesis in vivo, we investigated the dependence of IL-17 expression on TNF?
Negative_regulation (reduced) of Gene_expression (expression) of IL-17 associated with addiction
15) Confidence 0.23 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571924 Disease Relevance 0.80 Pain Relevance 0.47
The beneficial effect of CpdA required expression of the GR in T cells and was achieved by down regulating LFA-1 and CD44 on peripheral Th cells and by repressing IL-17 production.


Negative_regulation (repressing) of Gene_expression (production) of IL-17 in T cells
16) Confidence 0.22 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2781169 Disease Relevance 0.65 Pain Relevance 0.10
In addition, particular attention was paid to the IL-17 gene family since IL-17A protein was one of the cytokines that discriminated between BCG and the other pro-inflammatory stimuli (Table 3).
Negative_regulation (discriminated) of Gene_expression (one) of IL-17A protein associated with inflammatory stimuli and cytokine
17) Confidence 0.21 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 0.29 Pain Relevance 0.51
We also confirmed that 1,25(OH)2D3 inhibited Foxp3 and IL-17 expression in a dose-dependent manner (data not shown).
Negative_regulation (inhibited) of Gene_expression (expression) of IL-17
18) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0 Pain Relevance 0
The VDR signal on the CD4+ T cells inhibits the expression of IL-17, IL-2, Foxp3, and CCR6 but enhances the expression of IL-10.
Negative_regulation (inhibits) of Gene_expression (expression) of IL-17 in T cells
19) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.38 Pain Relevance 0.09
After onset of arthritis, mice were treated with soluble TNFR-Fc for 10 d and the production of IL-17 and IFN?
Negative_regulation (treated) of Gene_expression (production) of IL-17 associated with arthritis
20) Confidence 0.16 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571924 Disease Relevance 0.67 Pain Relevance 0.39

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox