INT140342

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Context Info
Confidence 0.11
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 4.27
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (SGCB) cytoskeleton organization (SGCB) cytoplasm (SGCB)
SGCB (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 27 99.08 Very High Very High Very High
headache 4 53.12 Quite High
bradykinin 8 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 456 100.00 Very High Very High Very High
Disease 149 100.00 Very High Very High Very High
Migraine With Aura 22 99.08 Very High Very High Very High
Adhesions 4 88.64 High High
Increased Venous Pressure Under Development 16 78.16 Quite High
Hypertension 43 74.48 Quite High
Anxiety Disorder 27 65.60 Quite High
Headache Disorders 1 53.52 Quite High
Hemiplegia 1 37.04 Quite Low
Inborn Genetic Diseases 24 32.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
demonstrated that sGC is a nucleotide sensor whose responsiveness to NO is regulated by ATP.
Regulation (regulated) of sGC
1) Confidence 0.11 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC555773 Disease Relevance 0.31 Pain Relevance 0
Building on his experience in Galveston—where he, Tips, Smith, and McNutt had developed a model of “whole family” or “family centered” genetic counselling66—Lynch argued the case for clinically-trained genetic counsellors to address the problems of hereditary cancer.67 In an increasingly specialized and fractured health care system, such a genetic counsellor would, ideally, be someone able to mediate all the information given to patients and their families; provide a more nuanced communication of the nature of disease and heredity; address the families' emotional responses to these efforts; and elicit better information on other family members who might be at risk.
Regulation (responses) of families associated with cancer and disease
2) Confidence 0.03 Published 2006 Journal Medical History Section Body Doc Link PMC1483189 Disease Relevance 0.81 Pain Relevance 0
Building on his experience in Galveston—where he, Tips, Smith, and McNutt had developed a model of “whole family” or “family centered” genetic counselling66—Lynch argued the case for clinically-trained genetic counsellors to address the problems of hereditary cancer.67 In an increasingly specialized and fractured health care system, such a genetic counsellor would, ideally, be someone able to mediate all the information given to patients and their families; provide a more nuanced communication of the nature of disease and heredity; address the families' emotional responses to these efforts; and elicit better information on other family members who might be at risk.
Regulation (responses) of families associated with cancer and disease
3) Confidence 0.03 Published 2006 Journal Medical History Section Body Doc Link PMC1483189 Disease Relevance 0.78 Pain Relevance 0
Lynch hoped that by targeting cancer families it would be possible to catch more cancers at an earlier stage than was hitherto possible.
Regulation (targeting) of families associated with cancer
4) Confidence 0.02 Published 2006 Journal Medical History Section Body Doc Link PMC1483189 Disease Relevance 1.21 Pain Relevance 0
The families we identified with FHM mutations in the CACNA1A and ATP1A2 genes were extended, multiple affected families whereas the remaining FHM families were smaller.
Regulation (affected) of families associated with migraine
5) Confidence 0.00 Published 2007 Journal Brain Section Abstract Doc Link 17142831 Disease Relevance 1.16 Pain Relevance 1.25

General Comments

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