INT140350

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Context Info
Confidence 0.36
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 3.97
Pain Relevance 4.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (C2) extracellular region (C2)
Anatomy Link Frequency
anterior 1
cartilage 1
posterior 1
C2 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 30 100.00 Very High Very High Very High
Kinase C 13 100.00 Very High Very High Very High
psoriasis 1 99.04 Very High Very High Very High
Pain 103 98.48 Very High Very High Very High
Potency 13 98.48 Very High Very High Very High
Spinal cord 14 98.28 Very High Very High Very High
Eae 36 97.84 Very High Very High Very High
Glutamate receptor 12 96.52 Very High Very High Very High
Antinociceptive 180 95.44 Very High Very High Very High
Glutamate 84 94.68 High High
Disease Link Frequency Relevance Heat
Skin Cancer 1 99.56 Very High Very High Very High
Psoriasis 2 99.04 Very High Very High Very High
Pain 89 98.48 Very High Very High Very High
Nociception 67 98.36 Very High Very High Very High
Inflammatory Pain 7 97.84 Very High Very High Very High
Injury 41 92.52 High High
Arthritis 44 91.56 High High
INFLAMMATION 139 90.80 High High
Hypersensitivity 5 90.28 High High
Synovitis 3 89.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Analysis of the chemical structure showed that the relaxant activity was progressively diminished by the presence of hydroxyl group at C-3, saturation of the C-2, C-3 double bound, saturation of the C-2, C-3 double bound coupled with lack of the C-4 carbonyl and glycosylation.
C-2 Binding (saturation) of
1) Confidence 0.36 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18840426 Disease Relevance 0 Pain Relevance 0.16
This assay was used during the initial studies with compounds C1 and C2 in order to establish differences in potency using different routes of administration.
C2 Binding (compounds) of associated with potency
2) Confidence 0.28 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2817697 Disease Relevance 0.18 Pain Relevance 0.81
Different groups of animals (n = 8) were treated p.o. with compounds C1 and C2 (300 mg.kg-1), morphine hydrochloride (20 mg.kg-1), or vehicle, or i.p. with compounds C1 and C2 (10, 30, 100, 300 mg.kg-1) or vehicle.
C2 Binding (compounds) of associated with morphine
3) Confidence 0.28 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2817697 Disease Relevance 0.16 Pain Relevance 0.42
Compound C2 showed dose-related activity too, reducing by 51%, 56%, 66%, and 69% (p ?
C2 Binding (Compound) of
4) Confidence 0.28 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2817697 Disease Relevance 0.34 Pain Relevance 0.77
Different groups of animals (n = 8) were treated i.p. with compounds C1 and C2 (10, 30, 100 and 300 mg.kg-1) (dose- related to determine ED50).
C2 Binding (compounds) of
5) Confidence 0.28 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2817697 Disease Relevance 0.22 Pain Relevance 0.49
Different groups of animals (n = 8) were treated p.o. with compounds C1 and C2 (300 mg.kg-1), morphine hydrochloride (20 mg.kg-1), or vehicle, or i.p. with compounds C1 and C2 (10, 30, 100, 300 mg.kg-1) or vehicle.
C2 Binding (compounds) of associated with morphine
6) Confidence 0.28 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2817697 Disease Relevance 0.15 Pain Relevance 0.40
Compounds C1 and C2 were evaluated in the hot-plate thermal nociception model by p.o. route.
C2 Binding (Compounds) of associated with nociception
7) Confidence 0.28 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2817697 Disease Relevance 0.24 Pain Relevance 0.43
We previously demonstrated that the C2 domain of PKC plays a critical role in these interactions.
C2 Binding (interactions) of associated with kinase c
8) Confidence 0.25 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17142835 Disease Relevance 0.14 Pain Relevance 0.42
How the alternative pathway is activated is still a matter of speculation: one method would be the formation and stabilization of surface-bound C3b-IgG fragments on the acellular cartilage surface, leading to formation of the C3 and C5 convertase.
C5 convertase Binding (formation) of in cartilage
9) Confidence 0.20 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 0.84 Pain Relevance 0.19
It binds to the RAGE C1 and C2 domains instead of the V domain [49].
C2 Binding (binds) of
10) Confidence 0.06 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 1.03 Pain Relevance 0.17
Antibody interference assays have shown that complex C1 is composed of Sp1 whereas complexes C2 and C3 consist mainly of Sp3 [9,15].
C2 Binding (complexes) of
11) Confidence 0.06 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0
With ligation of the C2 nerve root, direct access anterior to the spinal cord is possible.
C2 Binding (ligation) of in anterior associated with spinal cord
12) Confidence 0.04 Published 2010 Journal Journal of Craniovertebral Junction and Spine Section Body Doc Link PMC2944856 Disease Relevance 0 Pain Relevance 0.05
It winds around the lateral aspect and then the posterior aspect of the C2-C3 zygapophyseal joint.
C2 Binding (winds) of in posterior
13) Confidence 0.03 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693602 Disease Relevance 0.05 Pain Relevance 0.05
The comparison of the three methods used for the choice of cane length revealed that C2 was associated with the lowest energy expenditure, even though C2 was similar to C3 in length.
C2 Binding (associated) of
14) Confidence 0.03 Published 2008 Journal Clinics Section Body Doc Link PMC2664218 Disease Relevance 0.16 Pain Relevance 0.08
Other preoperative variables that were assessed included risk factors for nonunion, pathological abnormality responsible for C1-C2 instability, subject's clinical status including pain and presenting radiological findings.
C2 Binding (instability) of associated with pain
15) Confidence 0.03 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2995783 Disease Relevance 0.30 Pain Relevance 0.12
WHR was measured during walking without a cane (WWC) as well as walking with C1 (WC1), walking with C2 (WC2) and walking with C3 (WC3), providing the mean of 10 WHR measurements for each variable.
C2 Binding (walking) of
16) Confidence 0.02 Published 2008 Journal Clinics Section Body Doc Link PMC2664218 Disease Relevance 0.16 Pain Relevance 0.11
1 and has a calcium-binding C2 and two catalytic HKD domains.
C2 Binding (binding) of
17) Confidence 0.01 Published 2008 Journal Journal of Experimental Botany Section Body Doc Link PMC2561145 Disease Relevance 0 Pain Relevance 0

General Comments

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