INT140363

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Context Info
Confidence 0.58
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 2.49
Pain Relevance 2.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Rhoa) mitochondrion (Rhoa) cell morphogenesis (Rhoa)
intracellular (Rhoa) GTPase activity (Rhoa) cytoplasm (Rhoa)
Anatomy Link Frequency
smooth muscle 1
spinal cord 1
Rhoa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 16 99.76 Very High Very High Very High
Spinal cord 18 99.64 Very High Very High Very High
Serotonin 6 98.10 Very High Very High Very High
Pain 3 97.88 Very High Very High Very High
fluoxetine 6 97.64 Very High Very High Very High
Root ganglion neuron 3 95.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 7 99.64 Very High Very High Very High
Injury 15 99.44 Very High Very High Very High
Pain 3 97.88 Very High Very High Very High
Ganglion Cysts 3 95.36 Very High Very High Very High
Spinal Cord Injury 12 90.48 High High
Contusions 4 86.80 High High
Hypertension 3 5.00 Very Low Very Low Very Low
Hypoxia 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Long-term 5-HT stimulation also led to the inhibition of the RhoA/Rho kinase component of arterial contraction.
Negative_regulation (inhibition) of RhoA
1) Confidence 0.58 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17142836 Disease Relevance 0 Pain Relevance 0.21
This association was calcium-dependent and inhibited by fluoxetine and monodansylcadaverin. 5-HT promotes the association of RhoA with the E3 ubiquitin ligase Smurf1, and 5-HT-induced RhoA depletion was inhibited by the proteasome inhibitor MG132 and the RhoA inhibitor Tat-C3.
Negative_regulation (depletion) of RhoA associated with fluoxetine
2) Confidence 0.58 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17142836 Disease Relevance 0 Pain Relevance 0.25
Here we analyze the mechanisms of RhoA regulation by serotonin (5-HT) in arterial smooth muscle. 5-HT (0.1-10 microM) induced activation of RhoA followed by RhoA depletion at 24-72 h.
Negative_regulation (depletion) of RhoA in smooth muscle associated with serotonin
3) Confidence 0.58 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17142836 Disease Relevance 0 Pain Relevance 0.23
Nonsteroidal anti-inflammatory drugs promote axon regeneration via RhoA inhibition.
Negative_regulation (inhibition) of RhoA associated with inflammation and cinod
4) Confidence 0.55 Published 2007 Journal J. Neurosci. Section Title Doc Link 17428993 Disease Relevance 0.66 Pain Relevance 0.46
Here, we show that the nonsteroidal antiinflammatory drugs (NSAIDs) ibuprofen and indomethacin, the drugs widely used as pain relievers in the clinic, can surmount axon growth restrictions from myelin and proteoglycans by potently inhibiting their downstream pathway RhoA signal.
Negative_regulation (inhibiting) of RhoA associated with pain, inflammation and cinod
5) Confidence 0.55 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17428993 Disease Relevance 0.67 Pain Relevance 0.47
Unlike most other nonsteroidal anti-inflammatory drugs, ibuprofen suppresses basal RhoA activity (Zhou et al., 2003).
Negative_regulation (suppresses) of RhoA associated with inflammation and cinod
6) Confidence 0.50 Published 2009 Journal J. Neurotrauma Section Abstract Doc Link 19125588 Disease Relevance 0.34 Pain Relevance 0.22
Systemic administration of ibuprofen to spinal cord-lesioned rodents reverses the active RhoA signal around injury area measured via Rho-GTP binding assay.
Negative_regulation (reverses) of RhoA in spinal cord associated with injury and spinal cord
7) Confidence 0.41 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17428993 Disease Relevance 0.82 Pain Relevance 0.63

General Comments

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