INT140371

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Context Info
Confidence 0.46
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Rhoa) mitochondrion (Rhoa) cell morphogenesis (Rhoa)
intracellular (Rhoa) GTPase activity (Rhoa) cytoplasm (Rhoa)
Rhoa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 2 97.80 Very High Very High Very High
Serotonin 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Hypertension 1 5.00 Very Low Very Low Very Low
Hypoxia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This association was calcium-dependent and inhibited by fluoxetine and monodansylcadaverin. 5-HT promotes the association of RhoA with the E3 ubiquitin ligase Smurf1, and 5-HT-induced RhoA depletion was inhibited by the proteasome inhibitor MG132 and the RhoA inhibitor Tat-C3.
Positive_regulation (induced) of Negative_regulation (depletion) of RhoA associated with fluoxetine
1) Confidence 0.46 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17142836 Disease Relevance 0 Pain Relevance 0.26

General Comments

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