INT140373

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Context Info
Confidence 0.48
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 0.28
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Rhoa) mitochondrion (Rhoa) cell morphogenesis (Rhoa)
intracellular (Rhoa) GTPase activity (Rhoa) cytoplasm (Rhoa)
Rhoa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 2 93.44 High High
cINOD 1 86.32 High High
Serotonin 2 80.08 Quite High
Spinal cord 6 75.00 Quite High
dexamethasone 9 5.00 Very Low Very Low Very Low
addiction 9 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 1 84.88 Quite High
Spinal Cord Injury 6 75.00 Quite High
Hepatocellular Cancer 12 30.84 Quite Low
Contusions 1 25.00 Low Low
Adhesions 3 5.00 Very Low Very Low Very Low
Stress 3 5.00 Very Low Very Low Very Low
Volume Depletion And Dehydration 3 5.00 Very Low Very Low Very Low
Hypertension 1 5.00 Very Low Very Low Very Low
Hypoxia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Coimmunoprecipitations demonstrated that 5-HT associated with RhoA both in vitro and in vivo.
RhoA Binding (associated) of
1) Confidence 0.48 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17142836 Disease Relevance 0 Pain Relevance 0.26
The GTP-binding protein RhoA regulates microfilament dynamics in many cell types and mediates the inhibition of axonal regeneration by myelin and chondroitin sulfate proteoglycans.
RhoA Binding (binding) of
2) Confidence 0.32 Published 2009 Journal J. Neurotrauma Section Abstract Doc Link 19125588 Disease Relevance 0.28 Pain Relevance 0.18
Although the actual mechanism facilitating peroxisome acto-myosin interaction is not known, binding of RhoA-GTP to the peroxisomal membrane may trigger this process possibly by activating NMM IIA.
RhoA Binding (binding) of
3) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2975642 Disease Relevance 0 Pain Relevance 0
Concomitantly, activated RhoA may favor peroxisome association with the actin cytoskeleton possibly by recruiting Rho kinase (ROCKII).
RhoA Binding (association) of
4) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2975642 Disease Relevance 0 Pain Relevance 0
Our studies indicate a sequence of events in which activated RhoA by binding to peroxisomes detaches the organelles from microtubules.
RhoA Binding (binding) of
5) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2975642 Disease Relevance 0 Pain Relevance 0

General Comments

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