INT140380

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Context Info
Confidence 0.31
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.50
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ikbkb) kinase activity (Ikbkb) cytoplasm (Ikbkb)
Anatomy Link Frequency
T cells 1
Ikbkb (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1 88.92 High High
Neuritis 1 87.96 High High
Multiple sclerosis 4 82.16 Quite High
tolerance 6 29.72 Quite Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 3 92.00 High High
INFLAMMATION 1 88.92 High High
Optic Neuritis 1 87.96 High High
Paralysis 1 85.56 High High
Recurrence 5 84.36 Quite High
Multiple Sclerosis 6 82.96 Quite High
Diabetes Mellitus 22 80.12 Quite High
Obesity 11 76.00 Quite High
Insulin Resistance 7 75.04 Quite High
Brain Disease 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IKBKB can phosphorylate IRS1 on Ser307, thereby rendering IRS1 less amenable to become phosphorylated on tyrosine residues required to propagate the signal to downstream effectors such as protein kinase B [23].
Phosphorylation (phosphorylate) of IKBKB
1) Confidence 0.31 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952334 Disease Relevance 0.30 Pain Relevance 0
Opn promoted the survival of activated T cells by inhibiting the transcription factor Foxo3a, by activating the transcription factor NF-kappaB through induction of phosphorylation of the kinase IKKbeta and by altering expression of the proapoptotic proteins Bim, Bak and Bax.
Phosphorylation (phosphorylation) of IKKbeta in T cells
2) Confidence 0.14 Published 2007 Journal Nat. Immunol. Section Abstract Doc Link 17143274 Disease Relevance 1.20 Pain Relevance 0.29

General Comments

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