INT140381

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Context Info
Confidence 0.12
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.21
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ikbkb) kinase activity (Ikbkb) cytoplasm (Ikbkb)
Anatomy Link Frequency
T cells 2
Ikbkb (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1 89.44 High High
Neuritis 1 88.48 High High
Multiple sclerosis 4 82.16 Quite High
Disease Link Frequency Relevance Heat
Death 2 92.52 High High
INFLAMMATION 1 89.44 High High
Optic Neuritis 1 88.48 High High
Paralysis 1 86.08 High High
Recurrence 5 84.88 Quite High
Multiple Sclerosis 6 83.48 Quite High
Brain Disease 1 75.00 Quite High
Disease 1 71.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Opn promoted the survival of activated T cells by inhibiting the transcription factor Foxo3a, by activating the transcription factor NF-kappaB through induction of phosphorylation of the kinase IKKbeta and by altering expression of the proapoptotic proteins Bim, Bak and Bax.
Positive_regulation (induction) of Phosphorylation (phosphorylation) of IKKbeta in T cells
1) Confidence 0.12 Published 2007 Journal Nat. Immunol. Section Abstract Doc Link 17143274 Disease Relevance 1.21 Pain Relevance 0.29

General Comments

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