INT140385

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.29
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Spp1, FOXO3) nucleoplasm (FOXO3) embryo development (FOXO3)
DNA binding (FOXO3) response to stress (FOXO3) cytosol (FOXO3)
Anatomy Link Frequency
T cells 1
Spp1 (Mus musculus)
FOXO3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1 95.48 Very High Very High Very High
Neuritis 1 94.52 High High
Multiple sclerosis 4 85.72 High High
Disease Link Frequency Relevance Heat
Death 2 98.56 Very High Very High Very High
INFLAMMATION 1 95.48 Very High Very High Very High
Optic Neuritis 1 94.52 High High
Paralysis 1 92.12 High High
Recurrence 5 90.92 High High
Multiple Sclerosis 6 89.52 High High
Disease 1 77.16 Quite High
Brain Disease 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Opn promoted the survival of activated T cells by inhibiting the transcription factor Foxo3a, by activating the transcription factor NF-kappaB through induction of phosphorylation of the kinase IKKbeta and by altering expression of the proapoptotic proteins Bim, Bak and Bax.
Opn Negative_regulation (inhibiting) of Foxo3a in T cells
1) Confidence 0.04 Published 2007 Journal Nat. Immunol. Section Abstract Doc Link 17143274 Disease Relevance 1.29 Pain Relevance 0.30

General Comments

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