INT140400

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Context Info
Confidence 0.36
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 3.59
Pain Relevance 2.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Scn9a)
Scn9a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nav1.7 5 100.00 Very High Very High Very High
Nav1.2 1 98.24 Very High Very High Very High
Pain 6 98.12 Very High Very High Very High
primary erythermalgia 5 97.56 Very High Very High Very High
carbamazepine 1 92.88 High High
nav1.8 1 91.20 High High
Limbic system 2 90.12 High High
Paroxysmal extreme pain disorder 6 89.44 High High
Hippocampus 2 88.72 High High
sodium channel 2 86.24 High High
Disease Link Frequency Relevance Heat
Bronchopulmonary Dysplasia 18 99.24 Very High Very High Very High
Pain 6 98.12 Very High Very High Very High
Erythermalgia 5 97.24 Very High Very High Very High
Dissociative Disorders 2 92.40 High High
Somatoform Disorder 6 89.44 High High
Increased Venous Pressure Under Development 1 85.52 High High
Injury 66 82.04 Quite High
Attention Deficit Hyperactivity Disorder 2 79.00 Quite High
Borderline Personality 4 75.00 Quite High
Mental Disorders 2 74.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both the genes coding for the a subunit Nav1.7 (Scn9a) and the ?
Scn9a Binding (coding) of associated with nav1.7
1) Confidence 0.36 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2900267 Disease Relevance 0.19 Pain Relevance 0.29
The aim of the present study was to test for associations between SCN9A gene variants and BPD as well as BPD-related phenotypes.
SCN9A Binding (associations) of associated with bronchopulmonary dysplasia
2) Confidence 0.32 Published 2008 Journal J Psychiatr Res Section Abstract Doc Link 18439623 Disease Relevance 1.18 Pain Relevance 0.41
Other mutations in SCN9A associated with more negative activation thresholds are known to cause primary erythermalgia (PE).
SCN9A Binding (associated) of associated with primary erythermalgia and erythermalgia
3) Confidence 0.30 Published 2006 Journal Neuron Section Abstract Doc Link 17145499 Disease Relevance 1.17 Pain Relevance 1.13
In addition, p-values<0.05 were observed in the analysis of associations between SCN9A markers and dissociative symptoms.
SCN9A Binding (associations) of
4) Confidence 0.27 Published 2008 Journal J Psychiatr Res Section Abstract Doc Link 18439623 Disease Relevance 1.06 Pain Relevance 0.32

General Comments

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