INT140401

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Context Info
Confidence 0.47
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.22
Pain Relevance 2.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PEPD) cellular amino acid metabolic process (PEPD)
PEPD (Homo sapiens)
Pain Link Frequency Relevance Heat
Paroxysmal extreme pain disorder 66 100.00 Very High Very High Very High
primary erythermalgia 5 99.06 Very High Very High Very High
carbamazepine 12 98.14 Very High Very High Very High
Nav1.7 79 98.12 Very High Very High Very High
dorsal root ganglion 59 96.68 Very High Very High Very High
hyperexcitability 15 96.40 Very High Very High Very High
addiction 29 83.64 Quite High
Pain 41 81.28 Quite High
Neuropathic pain 2 71.12 Quite High
burning pain 1 60.88 Quite High
Disease Link Frequency Relevance Heat
Somatoform Disorder 67 100.00 Very High Very High Very High
Erythermalgia 39 100.00 Very High Very High Very High
Ganglion Cysts 60 96.68 Very High Very High Very High
Pain 35 81.28 Quite High
Increased Venous Pressure Under Development 2 77.08 Quite High
Neuropathic Pain 8 71.12 Quite High
Erythema 4 61.92 Quite High
Syndrome 2 29.08 Quite Low
Hypopituitarism 1 24.16 Low Low
Disease 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Carbamazepine, a drug that is effective in PEPD, but not PE, showed selective block of persistent current associated with PEPD mutants, but did not affect the negative activation threshold of a PE mutant.
PEPD Binding (associated) of associated with primary erythermalgia, paroxysmal extreme pain disorder and carbamazepine
1) Confidence 0.47 Published 2006 Journal Neuron Section Abstract Doc Link 17145499 Disease Relevance 1.21 Pain Relevance 1.19
Our findings also confirm the impairment of fast-inactivation previously associated with PEPD mutations, but show that, in addition, a PEPD mutation can enhance the response of the Nav1.7 channel to small, slow depolarizations and accelerate repriming.
PEPD Binding (associated) of associated with paroxysmal extreme pain disorder and nav1.7
2) Confidence 0.16 Published 2008 Journal Mol Pain Section Body Doc Link PMC2556659 Disease Relevance 0.74 Pain Relevance 1.04
Most mutations that underlie IEM and PEPD increase amplitude of ramp currents of mutant Nav1.7 channels even when the peak currents were either unchanged or even reduced [2].
PEPD Binding (underlie) of associated with paroxysmal extreme pain disorder, erythermalgia and nav1.7
3) Confidence 0.12 Published 2010 Journal Mol Pain Section Body Doc Link PMC2898769 Disease Relevance 0.27 Pain Relevance 0.74

General Comments

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