INT140413

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Context Info
Confidence 0.78
First Reported 2006
Last Reported 2010
Negated 13
Speculated 2
Reported most in Body
Documents 113
Total Number 147
Disease Relevance 139.25
Pain Relevance 25.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (AQP4) plasma membrane (AQP4) transmembrane transport (AQP4)
cytoplasm (AQP4)
Anatomy Link Frequency
astrocytes 10
plasma 6
brain 6
M-1 6
spinal cord 4
AQP4 (Homo sapiens)
Pain Link Frequency Relevance Heat
intrathecal 596 99.98 Very High Very High Very High
Multiple sclerosis 1415 99.88 Very High Very High Very High
Spinal cord 782 99.82 Very High Very High Very High
Central nervous system 770 99.82 Very High Very High Very High
Inflammation 681 99.68 Very High Very High Very High
cerebral cortex 65 99.68 Very High Very High Very High
Glutamate 864 99.04 Very High Very High Very High
addiction 112 98.88 Very High Very High Very High
Neuritis 1392 98.56 Very High Very High Very High
Demyelination 341 98.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuromyelitis Optica 8005 100.00 Very High Very High Very High
Targeted Disruption 451 99.98 Very High Very High Very High
Demyelinating Disease 2807 99.90 Very High Very High Very High
Atrophy 224 99.88 Very High Very High Very High
Thymoma 6 99.84 Very High Very High Very High
Recurrence 1676 99.68 Very High Very High Very High
INFLAMMATION 665 99.68 Very High Very High Very High
Prion Diseases 192 99.60 Very High Very High Very High
Systemic Lupus Erythematosus 355 99.50 Very High Very High Very High
Creutzfeldt Jakob Disease 321 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AQP4 autoantibodies from serum of NMO patients bound to AQP4 expressed on thymoma cell membrane.


Gene_expression (expressed) of AQP4
1) Confidence 0.78 Published 2010 Journal J. Neuroimmunol. Section Body Doc Link 20728226 Disease Relevance 0.11 Pain Relevance 0
AIM: We studied the expression of AQP4 by thymoma from patients with and without myasthenia gravis (MG).
Gene_expression (expression) of AQP4
2) Confidence 0.78 Published 2010 Journal J. Neuroimmunol. Section Body Doc Link 20728226 Disease Relevance 0.19 Pain Relevance 0
Serum NMO-IgG autoantibodies (Abs), a specific finding in NMO patients, target the water channel protein aquaporin-4 (AQP4), which is expressed as a long (M-1) or a short (M-23) isoform.


Gene_expression (expressed) of aquaporin-4 in M-1 associated with neuromyelitis optica
3) Confidence 0.78 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2864757 Disease Relevance 1.39 Pain Relevance 0.13
Thus we suggest that only M-23 AQP4 should be used as target antigen for the early detection of AQP4-IgG.
Gene_expression (detection) of AQP4-IgG
4) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864757 Disease Relevance 0.92 Pain Relevance 0.11
Additionally, serum Abs to full length AQP4 were also detected in the patient with isolated myelitis, but not in the patient with SLE-myelitis, who were both positive for M-23 AQP4-IgG.
Neg (not) Gene_expression (detected) of AQP4 associated with systemic lupus erythematosus and demyelinating disease
5) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864757 Disease Relevance 2.00 Pain Relevance 0.21
Serum NMO-IgG autoantibodies (Abs), a specific finding in NMO patients, target the water channel protein aquaporin-4 (AQP4), which is expressed as a long (M-1) or a short (M-23) isoform.


Gene_expression (expressed) of AQP4 in M-1 associated with neuromyelitis optica
6) Confidence 0.78 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2864757 Disease Relevance 1.39 Pain Relevance 0.13
However, AQP4-IgM were also detected in a low percentage of patients with MS and OND.
Gene_expression (detected) of AQP4-IgM associated with multiple sclerosis and neurological disease
7) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864757 Disease Relevance 1.13 Pain Relevance 0.14
In contrast, AQP4-IgG Abs were not present in patients with MS, OND, and non-neuropsychiatric SLE and in HC, which supports their high relevance as biological markers.
Neg (not) Gene_expression (present) of AQP4-IgG associated with multiple sclerosis, neurological disease and systemic lupus erythematosus
8) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864757 Disease Relevance 2.00 Pain Relevance 0.19
Expression of AQP4 in HEK-293A cells
Gene_expression (Expression) of AQP4
9) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864757 Disease Relevance 2.39 Pain Relevance 0.85
The target antigen of NMO-IgG was recently identified as aquaporin-4 (AQP4) water channel protein, which is mainly expressed in brain and spinal cord.
Gene_expression (expressed) of aquaporin-4 in spinal cord associated with neuromyelitis optica and spinal cord
10) Confidence 0.77 Published 2006 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 17146196 Disease Relevance 1.31 Pain Relevance 0.14
In the present study, we have established human cell lines that stably express human AQP4 and used these cells to detect and titrate anti-AQP4 antibody present in the sera of patients with NMO by immunofluorescence assay.
Gene_expression (express) of AQP4 associated with neuromyelitis optica
11) Confidence 0.77 Published 2006 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 17146196 Disease Relevance 1.38 Pain Relevance 0.13
JSCK transfected the HEK293 cells with human AQP4 gene and is one of the investigators who interpreted the immunofluorescence results.
Gene_expression (transfected) of AQP4 gene
12) Confidence 0.77 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2941752 Disease Relevance 0 Pain Relevance 0
Transfected HEK 293 cells express human AQP4 homotetramers closely packed on cell membranes [37], and allow detection of AQP4 autoantibodies binding to extracellular epitopes of human AQP4.
Gene_expression (express) of AQP4
13) Confidence 0.77 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2941752 Disease Relevance 1.48 Pain Relevance 0.19
AQP4 autoantibodies seropositivity rates are reported to be higher by IIFA using transfected mammalian cells which express human AQP4 on their cell membranes (cell-based IIFA) than by IIFA using mammalian CNS tissue (tissue-based IIFA).
Gene_expression (express) of AQP4
14) Confidence 0.77 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2941752 Disease Relevance 0.74 Pain Relevance 0.25
Cells were examined under a microscope for green fluorescence over cell membranes from expression of the GFP-AQP4 fusion protein, and stably transfected cells were selected by G418 (Invitrogen) at 1200 ?
Gene_expression (expression) of AQP4
15) Confidence 0.77 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2941752 Disease Relevance 0 Pain Relevance 0
A specific auto-antibody, NMO-IgG, was detected in the serum of NMO patients, and aquaporin-4 water channel protein was detected as its target antigen; aquaporin-4 water channel protein is localized at the end-feet of astrocytes.
Gene_expression (detected) of aquaporin-4 in astrocytes associated with neuromyelitis optica
16) Confidence 0.75 Published 2010 Journal Brain Nerve Section Abstract Doc Link 20844302 Disease Relevance 1.57 Pain Relevance 0.32
Expression of AQP4 in the brain and spinal cord is associated with astrocyte membranes that appose endothelial cell basal membranes.
Gene_expression (Expression) of AQP4 in spinal cord associated with spinal cord
17) Confidence 0.73 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2904295 Disease Relevance 1.85 Pain Relevance 0.46
Several studies have reported that areas of CNS inflammation correlate with expression pattern of AQP4 in NMO [22,23].
Gene_expression (expression) of AQP4 associated with neuromyelitis optica, inflammation and central nervous system
18) Confidence 0.73 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2904295 Disease Relevance 1.99 Pain Relevance 0.52
We recently demonstrated in vitro the pathogenicity of NMO-IgG for nonneural cells transgenically expressing AQP4, and that NMO serum IgM is not AQP4 specific.
Gene_expression (expressing) of AQP4 associated with neuromyelitis optica
19) Confidence 0.71 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 1.52 Pain Relevance 0.34
Transport-competent EAAT2 protein is up-regulated in differentiating astrocyte progenitors and in nonneural cells expressing AQP4 transgenically.
Gene_expression (expressing) of AQP4 in astrocyte
20) Confidence 0.71 Published 2008 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2571922 Disease Relevance 0.97 Pain Relevance 0.40

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