INT14043

Context Info Confidence 0.30 First Reported 1982 Last Reported 2010 Negated 0 Speculated 3 Reported most in Body Documents 52 Total Number 55 Disease Relevance 26.56 Pain Relevance 7.76

extracellular region (HP)

Anatomy Link Frequency Stage 1 2 brain 1 brainstem 1 pallidum 1 autonomic 1 HP (Homo sapiens)

Pain Link Frequency Relevance Heat Catecholamine 99 100.00 Dopamine 88 100.00 Clonidine 21 100.00 agonist 11 100.00 cINOD 46 99.76 cerebral cortex 1 99.36 medulla 9 99.12 Serotonin 11 98.88 opiate 2 98.52 Potency 8 97.54

Disease Link Frequency Relevance Heat Manic Depressive Disorder 2232 100.00 Hypertension 372 100.00 Cancer 147 100.00 Ulcers 48 100.00 Prehypertension 14 100.00 Metastasis 5 100.00 Infection 26 99.96 Cardiovascular Disease 57 99.92 Aggression 72 99.60 Obsessive-compulsive Disorder 2 99.46

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In both soluble and membrane fractions, the alpha 2-adrenoceptor binding being masked with (-)norepinephrine, [3H]clonidine bound to a low affinity site which was insensitive to (-)norepinephrine and which exhibited the same selectivity for various drugs as the [3H]idazoxan binding site. alpha 2-adrenoceptor binding was present in the membrane and the soluble fractions although it was difficult to detect in the soluble fraction because of inhibition of [3H]rauwolscine binding by the CHAPS detergent.

binding Binding (bound) of associated with clonidine

1) Confidence 0.30 Published 1994 Journal Neurochem. Int. Section Abstract Doc Link 7994199 Disease Relevance 0 Pain Relevance 0.33

I(2)-imidazoline binding site affinity of a structurally different type of ligands.

binding Binding (affinity) of

2) Confidence 0.30 Published 2002 Journal Bioorg. Med. Chem. Section Title Doc Link 11886814 Disease Relevance 0 Pain Relevance 0.09

Our results support the concept 1) the interaction between Hp infection and NSAID on gastro-duodenal ulcerations is antagonistic, 2) the Hp and NSAID are independent risk factors for peptic ulcerations in humans, 3) there is no need for the Hp eradication in NSAID-treated patients, and 4) the rate of ulcer complications (hemorrhage and perforation) remains constant despite the decrease in Hp and ulcer prevalence.

Hp Binding (interaction) of associated with ulcers, cinod, cva and infection

3) Confidence 0.29 Published 2002 Journal Med. Sci. Monit. Section Abstract Doc Link 12218957 Disease Relevance 2.61 Pain Relevance 1.20

Interaction of Helicobacter pylori (Hp) and nonsteroidal anti-inflammatory drugs (NSAID) on gastric mucosa and risk of ulcerations.

Hp Binding (Interaction) of associated with inflammation, ulcers and cinod

4) Confidence 0.29 Published 2002 Journal Med. Sci. Monit. Section Title Doc Link 12218957 Disease Relevance 1.70 Pain Relevance 0.88

The biochemical and pharmacological characteristics of [125I]YLFQPQRFamide binding to mounted tissue sections were comparable to those reported for the rat in a previous study. [125I]YLFQPQRFamide appeared to interact reversibly with high affinity binding sites (Kd = 0.06 nM), distinct from opiate receptors.

binding Spec (appeared) Binding (interact) of associated with opiate

5) Confidence 0.28 Published 1994 Journal Brain Res. Section Abstract Doc Link 8137150 Disease Relevance 0.09 Pain Relevance 0.40

These results indicate that potency increases with decreasing binding strength of the pi-HOMO electrons, suggesting that charge transfer may be important for interaction with specific or nonspecific binding sites.

binding Binding (interaction) of associated with potency

6) Confidence 0.27 Published 1982 Journal Mol. Pharmacol. Section Abstract Doc Link 7155122 Disease Relevance 0.15 Pain Relevance 0.28

PGE2 is associated with tumor metastases, IL-6 with cancer cell invasion, and haptoglobin with implantation and angiogenesis.

haptoglobin Binding (associated) of in PGE2 associated with cancer and metastasis

7) Confidence 0.14 Published 2000 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 10678579 Disease Relevance 1.97 Pain Relevance 0.42

Phenothiazines bind to a single common site of the erythrocyte membranes with relatively high binding affinities (K = 10(4)-10(5) M-1).

binding Binding (bind) of in M-1

8) Confidence 0.11 Published 1990 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 1981902 Disease Relevance 0.09 Pain Relevance 0.09

Statistical analysis of treatment effects on mean DBP and SBP and on mechanistic parameters was performed taking into account the study population, BP class (i.e. prehypertension or stage 1 hypertension), treatment, and interaction between treatment and BP class.

BP Binding (interaction) of in stage 1 associated with prehypertension and hypertension

9) Confidence 0.06 Published 2010 Journal Nutr J Section Body Doc Link PMC2989300 Disease Relevance 0.40 Pain Relevance 0

Most cardiovascular disease is associated with BP levels below the current definition of hypertension (WHO 2002), and there is a continuous association between usual BP and cardiovascular event risk down to 115 mm Hg SBP and 75 mm Hg DBP (PSC 2000).

BP Binding (association) of associated with cardiovascular disease, primary sclerosing cholangitis and hypertension

10) Confidence 0.06 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993997 Disease Relevance 0.95 Pain Relevance 0

Most cardiovascular disease is associated with BP levels below the current definition of hypertension (WHO 2002), and there is a continuous association between usual BP and cardiovascular event risk down to 115 mm Hg SBP and 75 mm Hg DBP (PSC 2000).

BP Binding (associated) of associated with cardiovascular disease, primary sclerosing cholangitis and hypertension

11) Confidence 0.05 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993997 Disease Relevance 0.90 Pain Relevance 0

Moreover, she is keenly aware that the cluster of behaviors that we call BP has been recognized for millennia and across cultures.

BP Binding (recognized) of associated with manic depressive disorder

12) Confidence 0.05 Published 2010 Journal Child Adolesc Psychiatry Ment Health Section Body Doc Link PMC2846895 Disease Relevance 0.56 Pain Relevance 0

Consistent with Burke's point about stress as a possible precipitant of the symptoms associated with BP and other diagnoses, is the research of workshop participant and child psychiatrist Boris Birmaher (and his colleagues), which suggests that low socio economic status is predictive of worse long-term BP outcomes [10].

BP Binding (associated) of associated with stress and manic depressive disorder

13) Confidence 0.05 Published 2010 Journal Child Adolesc Psychiatry Ment Health Section Body Doc Link PMC2846895 Disease Relevance 0.90 Pain Relevance 0

That is, because BP is associated with high heritability estimates and is treated primarily with medications, physicians may (erroneously) infer that psychosocial treatments will not be helpful, or may be less inclined to delve deeply into the quality of the child's home environment or family relations.

BP Binding (associated) of associated with manic depressive disorder

14) Confidence 0.05 Published 2010 Journal Child Adolesc Psychiatry Ment Health Section Body Doc Link PMC2846895 Disease Relevance 1.06 Pain Relevance 0.14

While some symptoms now associated with the BP label can be found in previous versions of the DSM in descriptions of disorders such as "unsocialized aggressive reaction of childhood," "adjustment reaction of childhood," and "schizophrenic reaction, childhood type," DSM's description of BP did not in the past and does not now explicitly address diagnosis of this disorder in childhood.

BP Binding (associated) of associated with manic depressive disorder and schizophrenia

15) Confidence 0.05 Published 2010 Journal Child Adolesc Psychiatry Ment Health Section Body Doc Link PMC2846895 Disease Relevance 0.85 Pain Relevance 0

Kinetics of [3H]UK-14,304 and [3H]clonidine binding indicated more complex agonist-receptor interactions than equilibrium data did.

binding Binding (interactions) of associated with agonist and clonidine

16) Confidence 0.04 Published 1989 Journal Mol. Pharmacol. Section Abstract Doc Link 2564632 Disease Relevance 0 Pain Relevance 1.11

Nevertheless, control of BP is important for patients receiving VSP inhibitor therapy for the following five reasons:Serious adverse events have been associated with unmanaged hypertension (1–3,5,34), and these could be prevented with control of BP before and early in the course of VSP inhibitor therapy.These agents can cause dramatic increases in BP from pretreatment measurements (as high as 29 mmHg systolic and 27 mmHg diastolic in one prospective clinical investigation) (35) during the first week of treatment (35,36), and currently, it cannot be predicted which patients will have this magnitude of BP elevation.Although minimalist approaches to hypertension for patients with incurable disease might be favored in certain circumstances, management of comorbidities, including hypertension, could improve overall survival.

BP Binding (approaches) of associated with hypertension and disease

17) Confidence 0.04 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2864290 Disease Relevance 0.82 Pain Relevance 0

One large study (37) demonstrated that the burden of comorbidities, especially when unmanaged, affects cancer patient survival as much as stage at diagnosis.As the indications for these agents expand to more chronic treatment courses, curative, and perhaps preventive settings, the goals of BP management then become similar to those for primary prevention of cardiovascular disease.Active control of hypertension should allow patients to tolerate the highest effective dose of VSP inhibitor therapy and benefit from the tumor growth control for the longest period, improving quality and length of life with VSP inhibitor therapy.

BP Binding (management) of associated with cardiovascular disease, cancer and hypertension

18) Confidence 0.04 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2864290 Disease Relevance 0.94 Pain Relevance 0

If the BP goal is not achieved, it may not be necessary to delay starting VSP inhibitor therapy until antihypertensive therapy is fully titrated, as long as the BP is below the level that is likely to be associated with acute complications.

BP Spec (likely) Binding (associated) of

19) Confidence 0.04 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2864290 Disease Relevance 0.14 Pain Relevance 0

Nevertheless, control of BP is important for patients receiving VSP inhibitor therapy for the following five reasons:Serious adverse events have been associated with unmanaged hypertension (1–3,5,34), and these could be prevented with control of BP before and early in the course of VSP inhibitor therapy.These agents can cause dramatic increases in BP from pretreatment measurements (as high as 29 mmHg systolic and 27 mmHg diastolic in one prospective clinical investigation) (35) during the first week of treatment (35,36), and currently, it cannot be predicted which patients will have this magnitude of BP elevation.Although minimalist approaches to hypertension for patients with incurable disease might be favored in certain circumstances, management of comorbidities, including hypertension, could improve overall survival.

BP Binding (control) of associated with hypertension and disease

20) Confidence 0.04 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2864290 Disease Relevance 0.65 Pain Relevance 0

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