INT140436

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Context Info
Confidence 0.39
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.34
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (TWIST1) DNA binding (TWIST1) transcription factor binding (TWIST1)
Anatomy Link Frequency
brain 1
parenchyma 1
TWIST1 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal-cord stimulation 15 100.00 Very High Very High Very High
headache 1 78.44 Quite High
Spinal cord 1 75.00 Quite High
cva 1 72.12 Quite High
ischemia 3 67.84 Quite High
fibrosis 5 66.00 Quite High
Neuropathic pain 1 50.00 Quite Low
Quantitative sensory testing 1 50.00 Quite Low
cytokine 6 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Focal Nodular Hyperplasia 2 97.76 Very High Very High Very High
Alcoholic Liver Diseases 2 96.68 Very High Very High Very High
Hyperplasia 2 96.64 Very High Very High Very High
Prostate Cancer 53 96.24 Very High Very High Very High
Necrosis 4 95.68 Very High Very High Very High
Gallstones 2 94.84 High High
Stroke 1 90.24 High High
Cancer 55 86.40 High High
Brain Injury 1 85.96 High High
Apoptosis 10 85.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, both VAV3 and TWIST1 are known to interact with growth factor signaling, which could be the effector mechanism in stimulating cellular proliferation.
TWIST1 Binding (interact) of associated with hyperplasia
1) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.77 Pain Relevance 0.03
In contrast, the results of thermal thresholds and tolerance to electrical stimulation at 2000 Hz tests did not change with the SCS trial.
SCS Neg (not) Binding (change) of
2) Confidence 0.36 Published 2006 Journal Pain Pract Section Body Doc Link 17147592 Disease Relevance 0.24 Pain Relevance 0
Accumulated evidence will be reviewed by the Washington State Health Technology Assessment Program to make decisions regarding all Washington State agencies' coverage for SCS.
SCS Binding (coverage) of
3) Confidence 0.36 Published 2010 Journal Med Care Section Body Doc Link 20473203 Disease Relevance 0 Pain Relevance 0
The authors' experimental studies confirm that SCS 1) interacts with CO2 with the mechanism of regulation of CBF in a competitive way and produce a reversible functional sympathectomy; 2) produces similar flowmetric changes in the brain as well as in the eyes; 3) can improve both clinical and haemodynamic ischemic stroke in humans; 4) prevents hemodynamic deterioration in the experimental combined ischemic and traumatic brain injury; 5) prevents experimental early vasospasm.
SCS 1 Binding (interacts) of in brain associated with stroke, increased venous pressure under development, brain injury and spinal-cord stimulation
4) Confidence 0.36 Published 2008 Journal J Neurosurg Sci Section Abstract Doc Link 18500217 Disease Relevance 0.72 Pain Relevance 0.44
The reciprocal interactions between SCs and their microenvironment, through cell-cell and cell-matrix connections as well as the secretion of soluble factors, influence SC behavior [17, 18].
SCs Binding (interactions) of
5) Confidence 0.06 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2963137 Disease Relevance 0.08 Pain Relevance 0
In such conditions, intermediates between hepatic SCs and hepatoblasts and between hepatoblasts and adult parenchyma are observed and amplification of one or both pluripotent cell subpopulations can occur [28].
SCs Binding (intermediates) of in parenchyma
6) Confidence 0.05 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2963137 Disease Relevance 0.52 Pain Relevance 0

General Comments

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