INT140446

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Title
Documents 2
Total Number 2
Disease Relevance 0.35
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Scn9a)
Scn9a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nav1.7 1 100.00 Very High Very High Very High
Nerve growth factor 10 99.84 Very High Very High Very High
primary erythermalgia 2 99.44 Very High Very High Very High
Neuropeptide 1 99.02 Very High Very High Very High
antagonist 1 96.80 Very High Very High Very High
sodium channel 2 94.48 High High
tetrodotoxin 3 92.88 High High
Disease Link Frequency Relevance Heat
Channelopathies 1 99.96 Very High Very High Very High
Erythermalgia 2 99.44 Very High Very High Very High
Reprotox - General 1 2 80.56 Quite High
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NGF did not affect the Nav1.7 mRNA level, but the total VGSC alpha-subunit protein level was upregulated.
Positive_regulation (upregulated) of Nav1.7 associated with nerve growth factor and nav1.7
1) Confidence 0.49 Published 2007 Journal J. Cell. Physiol. Section Abstract Doc Link 17149708 Disease Relevance 0.16 Pain Relevance 0.85
Primary erythermalgia as a sodium channelopathy: screening for SCN9A mutations: exclusion of a causal role of SCN10A and SCN11A.
Positive_regulation (screening) of SCN9A associated with primary erythermalgia, channelopathies and erythermalgia
2) Confidence 0.48 Published 2008 Journal Arch Dermatol Section Title Doc Link 18347287 Disease Relevance 0.20 Pain Relevance 0.33

General Comments

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