INT140449

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Context Info
Confidence 0.68
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.84
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Tap1) mitochondrion (Tap1) endoplasmic reticulum (Tap1)
ATPase activity (Tap1) plasma membrane (Tap1) transmembrane transport (Tap1)
Anatomy Link Frequency
tendon 1
superior 1
spleen 1
Tap1 (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 6 100.00 Very High Very High Very High
rheumatoid arthritis 17 84.20 Quite High
depression 5 72.12 Quite High
sSRI 2 48.08 Quite Low
Pain 6 27.20 Quite Low
Potency 7 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Viral Infection 15 99.78 Very High Very High Very High
Rupture 23 99.38 Very High Very High Very High
Flatfoot 14 91.56 High High
Tendinitis And Tenosynovitis 20 91.36 High High
Disease 2 86.08 High High
Rheumatoid Arthritis 21 84.20 Quite High
Depression 7 75.00 Quite High
Infection 57 59.00 Quite High
Congenital Anomalies 5 50.12 Quite High
Stress 1 35.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During an acute viral infection, however, TAP activity increases significantly owing to the rapid increase in the available intracellular peptide pool [31].
Positive_regulation (increases) of TAP associated with viral infection
1) Confidence 0.68 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.21 Pain Relevance 0
Increased TAP activity leads to more viral epitopes presented on the cell surface by MHC class I, resulting in increased immune responses.
Positive_regulation (Increased) of TAP
2) Confidence 0.68 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.16 Pain Relevance 0
The increase in VSV-specific CD8+ cells observed with VV-hTAP1,2 coinfections indicates a TAP-dependent increase in APC cross-priming and cross-presentation activity and is explained by an increase in TAP expression and peptide-transport activity in the APCs of the spleen.
Positive_regulation (increase) of TAP-dependent in spleen
3) Confidence 0.49 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.06 Pain Relevance 0
A post hoc analysis indicated that escitalopram was superior to fluoxetine on two items of the HAM-D-17: "depressed mood" (P =.023) and "work and interest" (P =.024).
Positive_regulation (superior) of HAM-D-17 in superior associated with fluoxetine
4) Confidence 0.44 Published 2008 Journal Depress Anxiety Section Abstract Doc Link 17149753 Disease Relevance 0.39 Pain Relevance 0.67
FHL tendon rupture was associated with a limited range of motion of MTP1, measured as a significant higher score of the JAM motion MTP1 (?
Positive_regulation (range) of MTP1 in tendon associated with rupture
5) Confidence 0.32 Published 2007 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2198913 Disease Relevance 1.03 Pain Relevance 0.07

General Comments

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