INT140465

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 2.11
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PECAM1) extracellular space (PECAM1) cell adhesion (PECAM1)
plasma membrane (PECAM1)
PECAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 3 100.00 Very High Very High Very High
Inflammation 3 100.00 Very High Very High Very High
aspirin 5 75.72 Quite High
cINOD 2 75.00 Quite High
Inflammatory marker 1 75.00 Quite High
Angina 2 52.12 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 7 100.00 Very High Very High Very High
Adhesions 6 100.00 Very High Very High Very High
INFLAMMATION 4 100.00 Very High Very High Very High
Coronary Artery Disease 9 99.84 Very High Very High Very High
Ganglion Cysts 2 95.08 Very High Very High Very High
Diabetic Retinopathy 5 75.00 Quite High
Hyperglycemia 1 69.44 Quite High
Death 1 66.00 Quite High
Cv General 3 Under Development 2 52.12 Quite High
Necrosis 1 34.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sulfasalazine (also as a representative of the salicylates) inhibited the diabetes-induced upregulation of several inflammatory gene products, which are regulated by NF-kappaB, including vascular cell adhesion molecule, intracellular adhesion molecule-1, inducible nitric oxide synthase, and cyclooxygenase-2 in whole-retinal lysate.
Negative_regulation (inhibited) of Positive_regulation (upregulation) of adhesion molecule associated with inflammation, diabetes mellitus and adhesions
1) Confidence 0.01 Published 2007 Journal Diabetes Section Abstract Doc Link 17259377 Disease Relevance 1.22 Pain Relevance 0.16
Revascularization seems to be an important factor suppressing both cytokine and adhesion molecule activation in CAD patients.
Negative_regulation (suppressing) of Positive_regulation (activation) of adhesion molecule associated with coronary artery disease, adhesions and cytokine
2) Confidence 0.00 Published 2006 Journal Heart Vessels Section Abstract Doc Link 17151818 Disease Relevance 0.89 Pain Relevance 0.22

General Comments

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