INT140476

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Context Info
Confidence 0.27
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 8
Disease Relevance 5.86
Pain Relevance 2.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (FABP3) cytoskeletal protein binding (FABP3) cytosol (FABP3)
Anatomy Link Frequency
chest 2
FABP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 78 98.60 Very High Very High Very High
ischemia 27 74.48 Quite High
Disease Link Frequency Relevance Heat
Acute Coronary Syndrome 148 99.40 Very High Very High Very High
Myocardial Infarction 101 99.20 Very High Very High Very High
Angina 56 98.60 Very High Very High Very High
Cv General 3 Under Development 22 95.00 High High
Necrosis 6 75.00 Quite High
Cv Unclassified Under Development 16 74.48 Quite High
Disease 16 59.28 Quite High
Coronary Artery Disease 11 45.92 Quite Low
Injury 3 44.60 Quite Low
Dyspnea 4 39.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The test characteristics of H-FABP and cardiac troponin T serum levels at admission revealed a greater sensitivity of H-FABP in the first 4 hours of symptoms (86% vs 42%, p <0.05).
Regulation (sensitivity) of H-FABP
1) Confidence 0.27 Published 2010 Journal Am. J. Cardiol. Section Abstract Doc Link 20102882 Disease Relevance 0.63 Pain Relevance 0.18
Sensitivity of TnT, CK-MB, and H-FABP in the first group (within 6 h of chest pain) were 38%, 76%, and 95% respectively.
Regulation (Sensitivity) of H-FABP in chest associated with angina
2) Confidence 0.27 Published 2006 Journal Heart Vessels Section Abstract Doc Link 17151819 Disease Relevance 1.24 Pain Relevance 0.68
Sensitivity of TnT, CK-MB, and H-FABP tests in the second time period (within 6-24 h of chest pain) were 100%, 90%, and 91% respectively.
Regulation (Sensitivity) of H-FABP in chest associated with angina
3) Confidence 0.27 Published 2006 Journal Heart Vessels Section Abstract Doc Link 17151819 Disease Relevance 1.21 Pain Relevance 0.62
The sensitivity of H-FABP was significantly higher than TnT (P=0.014).
Regulation (sensitivity) of H-FABP
4) Confidence 0.27 Published 2006 Journal Heart Vessels Section Abstract Doc Link 17151819 Disease Relevance 1.16 Pain Relevance 0.62
Using 2 by 2 tables the diagnostic value of the H-FABP test alone and in combination with the clinical score will be assessed, using AMI as the outcome, and positive and negative predictive values, sensitivity and specificity will be calculated with 95% confidence interval.
Regulation (value) of H-FABP associated with myocardial infarction
5) Confidence 0.15 Published 2008 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2358877 Disease Relevance 0.51 Pain Relevance 0.30
We will validate the diagnostic accuracy of this clinical score and estimate the added value of the H-FABP bedside test.


Regulation (value) of H-FABP
6) Confidence 0.15 Published 2008 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2358877 Disease Relevance 0.45 Pain Relevance 0
Several previous hospital-based studies showed the potential value of H-FABP in diagnosing ACS.
Regulation (value) of H-FABP associated with acute coronary syndrome
7) Confidence 0.15 Published 2008 Journal BMC Cardiovasc Disord Section Abstract Doc Link PMC2358877 Disease Relevance 0.35 Pain Relevance 0.09
This will lead to 2 different areas under the ROC-curve (AUC), where the difference in AUC presents the added value of the H-FABP test.
Regulation (value) of H-FABP
8) Confidence 0.15 Published 2008 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2358877 Disease Relevance 0.30 Pain Relevance 0

General Comments

This test has worked.

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