INT14049

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Context Info
Confidence 0.70
First Reported 1991
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 102
Total Number 109
Disease Relevance 48.31
Pain Relevance 71.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GRIN1)
Anatomy Link Frequency
brain 5
neurons 4
neural 3
plasma 2
hippocampus 2
GRIN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor 1394 100.00 Very High Very High Very High
Glutamate 1018 100.00 Very High Very High Very High
Dopamine 208 100.00 Very High Very High Very High
Glutamate receptor 205 100.00 Very High Very High Very High
Neurotransmitter 190 100.00 Very High Very High Very High
nociceptor 62 100.00 Very High Very High Very High
Kinase C 28 100.00 Very High Very High Very High
agonist 200 99.96 Very High Very High Very High
Pyramidal cell 183 99.96 Very High Very High Very High
medulla 66 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 145 99.92 Very High Very High Very High
INFLAMMATION 304 99.86 Very High Very High Very High
Death 194 99.78 Very High Very High Very High
Toxicity 307 99.56 Very High Very High Very High
Myalgia 12 99.46 Very High Very High Very High
Substance Withdrawal Syndrome 8 99.44 Very High Very High Very High
Stress 712 99.40 Very High Very High Very High
Hyperalgesia 136 99.40 Very High Very High Very High
Pain 1000 99.24 Very High Very High Very High
Autism 2519 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The attenuation of glutamate-induced mechanical sensitization by ketamine suggests that this effect is mediated, in part, through activation of peripheral NMDA receptors.
Positive_regulation (activation) of NMDA associated with glutamate, ketamine and nmda receptor
1) Confidence 0.70 Published 2006 Journal Exp Brain Res Section Abstract Doc Link 16292641 Disease Relevance 0.52 Pain Relevance 1.19
Since frequent activation of NMDARs can cause a successive decrease of the response amplitude, the stimulus frequency was kept low, usually at one per minute.
Positive_regulation (activation) of NMDA
2) Confidence 0.67 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1959237 Disease Relevance 0.28 Pain Relevance 0.18
In both cotransfected cells and cultured hippocampal neurons the activation of NMDA receptors increases the number of D1 receptors on the plasma membrane surface and enhances D1 receptor-mediated cAMP accumulation via a SNARE-dependent mechanism.
Positive_regulation (activation) of NMDA in plasma associated with nmda receptor
3) Confidence 0.67 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14762133 Disease Relevance 0 Pain Relevance 0.48
The increased NMDA aAB level was observed during the first year after skull injury.
Positive_regulation (increased) of NMDA in skull associated with injury
4) Confidence 0.67 Published 2006 Journal Zh Nevrol Psikhiatr Im S S Korsakova Section Abstract Doc Link 16972597 Disease Relevance 0.83 Pain Relevance 0.31
Activation of NMDA receptors in the brainstem, rostral ventromedial medulla, and nucleus reticularis gigantocellularis mediates mechanical hyperalgesia produced by repeated intramuscular injections of acidic saline in rats.
Positive_regulation (Activation) of NMDA in brainstem associated with medulla, hyperalgesia, nociceptor, nmda receptor and rostral ventromedial medulla
5) Confidence 0.67 Published 2010 Journal J Pain Section Title Doc Link 19853525 Disease Relevance 0.60 Pain Relevance 0.98
The activation of NMDA receptors including NR2A and NR2B subunits and L-type voltage-gated calcium channels (L-VDCCs) causes an increase in postsynaptic calcium in dendritic spines [11,13].
Positive_regulation (activation) of NMDA in spines associated with calcium channel and nmda receptor
6) Confidence 0.67 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734546 Disease Relevance 0.31 Pain Relevance 0.98
Cdk5 was shown to facilitate the calpain-mediated degradation of NR2B upon activation of NMDARs.
Positive_regulation (activation) of NMDA
7) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 0.36 Pain Relevance 0.11
The immediate increase in glucocorticoids acts on hippocampal glucocorticoid receptors, normally unresponsive to low circulating levels of cortisol, while glutamate activates hippocampal NMDA receptors (see Figure 3 for detailed description).
Positive_regulation (activates) of NMDA associated with glutamate and nmda receptor
8) Confidence 0.67 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.92 Pain Relevance 0.58
Because activation of NMDA receptors is required for LTP, the reduction of LTP in BDE-47–treated mice could reflect an alteration of NMDA receptor-associated signaling elements.
Positive_regulation (activation) of NMDA associated with nmda receptor and long-term potentiation
9) Confidence 0.67 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1892123 Disease Relevance 0.05 Pain Relevance 0.42
Furthermore, activation of NK1 receptors or NMDA receptors is required for LTP.
Positive_regulation (activation) of NMDA associated with nmda receptor and long-term potentiation
10) Confidence 0.67 Published 2007 Journal Mol Pain Section Body Doc Link PMC1904186 Disease Relevance 0.43 Pain Relevance 1.28
In contrast, theta-burst potentiation (see Additional File 2 for information on different stimulation protocols), which requires activation of both NMDA receptors and voltage-dependent Ca2+-channels was not affected by corticosterone treatment.
Positive_regulation (activation) of NMDA associated with nmda receptor
11) Confidence 0.67 Published 2010 Journal Mol Brain Section Body Doc Link PMC2841592 Disease Relevance 0 Pain Relevance 0.35
Because activation of NMDA receptors results in an influx of Ca2+ and, as mentioned above, Ca2+ determines the AHP amplitude [99], corticosteroid-NMDA receptor interactions have been analyzed in a number of studies using electrophysiological recordings as the endpoint.
Positive_regulation (activation) of NMDA associated with corticosteroid and nmda receptor
12) Confidence 0.67 Published 2010 Journal Mol Brain Section Body Doc Link PMC2841592 Disease Relevance 0 Pain Relevance 0.50
Loss of consciousness will occur, if the brain's representational activity falls below a critical threshold. (2) Higher-order mental representations are instantiated by neural cell assemblies. (3) The formation of such assemblies involves the activation of the NMDA receptor channel complex.
Positive_regulation (activation) of NMDA in neural associated with nmda receptor and unconsciousness
13) Confidence 0.67 Published 1998 Journal Toxicol. Lett. Section Abstract Doc Link 10049147 Disease Relevance 0.10 Pain Relevance 0.20
A significant increase in the level of the NR1 subunit mRNA was found in the locus coeruleus and the hypothalamic paraventricular nucleus following 3 days of intracerebroventricular (i.c.v.) morphine infusion (26 nmol microl(-1) h(-1)) through osmotic minipumps.
Positive_regulation (increase) of NR1 in nucleus associated with locus ceruleus, intracerebroventricular and morphine
14) Confidence 0.67 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9988122 Disease Relevance 0.17 Pain Relevance 0.94
This LTP did not require the activation of postsynaptic gamma-aminobutyric acid-A (GABA(A)) receptors but depended on the activation of NMDA receptors.
Positive_regulation (activation) of NMDA associated with gaba and nmda receptor
15) Confidence 0.67 Published 2000 Journal J. Neurophysiol. Section Abstract Doc Link 10980014 Disease Relevance 0 Pain Relevance 0.31
These results indicate that injection of glutamate into the masseter muscle evokes afferent discharges in rats and muscle pain in humans in part through activation of peripheral NMDA receptors.
Positive_regulation (activation) of NMDA in muscle associated with pain, glutamate, nmda receptor and myalgia
16) Confidence 0.59 Published 2003 Journal J. Neurophysiol. Section Abstract Doc Link 12815021 Disease Relevance 0.48 Pain Relevance 1.54
RESULTS: A significant increase in mRNA and protein for NMDA, AMPA, and KA receptor subunits was detected in inflamed compared with normal skin.
Positive_regulation (increase) of NMDA in skin
17) Confidence 0.53 Published 2008 Journal Br J Anaesth Section Body Doc Link 18238837 Disease Relevance 0.09 Pain Relevance 0
Since elevating extracellular/extrasynaptic glutamate by stimulating cystine exchange could also activate NMDA receptors similar to spillover effects of synaptically released glutamate [147], this aspect should not be overlooked in searching for the appropriate therapeutic dose of NAC.
Positive_regulation (activate) of NMDA associated with glutamate and nmda receptor
18) Confidence 0.49 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.62 Pain Relevance 0.51
The significant role of NMDA receptors and production of NO. in central sensitization, hyperalgesia, and chronic pain has been demonstrated in numerous models of peripheral injury.
Positive_regulation (role) of NMDA associated with hyperalgesia, central sensitization, lasting pain, nmda receptor and injury
19) Confidence 0.49 Published 1999 Journal Med. Clin. North Am. Section Abstract Doc Link 10386116 Disease Relevance 0.74 Pain Relevance 0.57
Hence, the rescue of spatial learning observed in Neto1-null mice may also be dependent on NR2B-NMDARs.
Positive_regulation (dependent) of NMDA
20) Confidence 0.49 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.25

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