INT140496

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Context Info
Confidence 0.29
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.43
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TRPC1) transmembrane transport (TRPC1)
Anatomy Link Frequency
B lymphocytes 1
platelets 1
TRPC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 2 98.68 Very High Very High Very High
Inflammation 20 96.96 Very High Very High Very High
cytokine 5 96.44 Very High Very High Very High
agonist 9 70.08 Quite High
antagonist 6 69.04 Quite High
Inflammatory mediators 3 25.00 Low Low
Hyperalgesia 1 25.00 Low Low
addiction 6 5.00 Very Low Very Low Very Low
TRP channel 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 27 96.96 Very High Very High Very High
Acidosis 1 96.80 Very High Very High Very High
Pathologic Processes 1 83.12 Quite High
Adhesions 10 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Neutrophil Disorders 4 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Pulmonary Disease 4 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Support for this hypothesis is derived from information obtained in human platelets and B lymphocytes, which suggests that TRPC1 is activated upon interaction with InsP3-Rs [57] and that it acts not only as a component of SOCs but also as a regulatory subunit of InsP3-Rs [58].
Positive_regulation (activated) of TRPC1 in B lymphocytes
1) Confidence 0.29 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
Transient receptor potential vanilloid (TRPV1), representing ion channel family, is activated in human and animal organism by capsaicin and some other factors such as heat, acidosis, and ion dysbalance.
Positive_regulation (activated) of Transient receptor associated with acidosis and qutenza
2) Confidence 0.13 Published 2006 Journal Eksp Klin Farmakol Section Abstract Doc Link 17153968 Disease Relevance 0.18 Pain Relevance 0.17
Support for this hypothesis is derived from information obtained in human platelets and B lymphocytes, which suggests that TRPC1 is activated upon interaction with InsP3-Rs [57] and that it acts not only as a component of SOCs but also as a regulatory subunit of InsP3-Rs [58].
Positive_regulation (activated) of TRPC1 in platelets
3) Confidence 0.10 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
In certain epithelial tissues, activation of transient receptor potential (TRP) vanilloid subtype 1 (TRPV1) by noxious stimuli induces pro-inflammatory cytokine release, which helps to mitigate the challenge.
Positive_regulation (activation) of transient receptor associated with inflammation and cytokine
4) Confidence 0.02 Published 2007 Journal J. Cell. Physiol. Section Abstract Doc Link 17508360 Disease Relevance 0.25 Pain Relevance 0.25

General Comments

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