INT140498

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Context Info
Confidence 0.56
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 1.58
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Tef)
Anatomy Link Frequency
hepatocyte 2
Tef (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 2 25.00 Low Low
carbamazepine 8 5.00 Very Low Very Low Very Low
Bile 4 5.00 Very Low Very Low Very Low
Paracetamol 4 5.00 Very Low Very Low Very Low
member 8 4 5.00 Very Low Very Low Very Low
antiepileptic Drug 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 4 99.96 Very High Very High Very High
Leukemia 4 99.08 Very High Very High Very High
Peptic Ulcer 2 92.88 High High
Aging 88 91.64 High High
Pressure And Volume Under Development 2 82.16 Quite High
Repression 12 66.20 Quite High
Cancer 4 59.92 Quite High
Wound Healing 1 58.00 Quite High
Disease 16 29.44 Quite Low
Toxicity 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The genes for two of these transcription factors, Dbp and Tef, were found to be differentially expressed throughout the life cycle in an age- and sex-specific manner (Figure 5A) and also to be highly correlated between the sexes (Pearson, R = 0.94).
Gene_expression (expressed) of Tef
1) Confidence 0.56 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0.16 Pain Relevance 0
In conclusion, it was shown that TEF presents antiinflammatory and antiulcer effects, partly due to its antioxidant action, known to be present in polyphenols, including tannins.
Gene_expression (presents) of TEF associated with inflammation
2) Confidence 0.52 Published 2007 Journal Phytother Res Section Abstract Doc Link 17154231 Disease Relevance 0.67 Pain Relevance 0
Master circadian regulators Clock and Arntl/Bmal1 (aryl hydrocarbon receptor nuclear translocator-like) control the expression of the PARbZip family of transcription factors which is comprised of three members: Dbp (albumin site D-binding protein), Tef (thyrotroph embryonic factor), and Hlf (hepatocyte leukemia factor).
Gene_expression (expression) of thyrotroph embryonic factor in hepatocyte associated with leukemia
3) Confidence 0.44 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0.32 Pain Relevance 0
Master circadian regulators Clock and Arntl/Bmal1 (aryl hydrocarbon receptor nuclear translocator-like) control the expression of the PARbZip family of transcription factors which is comprised of three members: Dbp (albumin site D-binding protein), Tef (thyrotroph embryonic factor), and Hlf (hepatocyte leukemia factor).
Gene_expression (expression) of Tef in hepatocyte associated with leukemia
4) Confidence 0.44 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0.32 Pain Relevance 0
It is interesting to note that the pattern of SCN-controlled clock genes, Dbp, Tef, and Hlf (Hlf's 1.3-fold change did not meet criteria for inclusion in list of DEGs) display a conspicuous correlation with these reports (Figure 5A).
Gene_expression (pattern) of Tef
5) Confidence 0.44 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0.12 Pain Relevance 0

General Comments

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