INT140503

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Context Info
Confidence 0.44
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 15
Disease Relevance 5.93
Pain Relevance 6.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp3) extracellular space (Mmp3) extracellular region (Mmp3)
proteinaceous extracellular matrix (Mmp3) nucleus (Mmp3) protein complex (Mmp3)
Anatomy Link Frequency
tears 2
chondrocytes 2
tendons 2
Mmp3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 689 100.00 Very High Very High Very High
spinal inflammation 2 99.28 Very High Very High Very High
Arthritis 36 98.92 Very High Very High Very High
Etanercept 2 98.66 Very High Very High Very High
Infliximab 2 98.36 Very High Very High Very High
Inflammation 61 98.08 Very High Very High Very High
Pain 22 96.72 Very High Very High Very High
chemokine 3 95.76 Very High Very High Very High
pulpitis 2 95.36 Very High Very High Very High
cytokine 18 95.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rotator Cuff Tears 270 99.48 Very High Very High Very High
Necrosis 3 99.34 Very High Very High Very High
Low Back Pain 2 99.28 Very High Very High Very High
Cancer 23 99.16 Very High Very High Very High
Arthritis 45 98.92 Very High Very High Very High
INFLAMMATION 66 98.08 Very High Very High Very High
Pain 21 96.72 Very High Very High Very High
Disease 71 96.52 Very High Very High Very High
Pulpitis 2 95.36 Very High Very High Very High
Cadaver 18 92.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pilocarpine (5 x 10(-11) mol/L to 5 x 10(-9) mol/L), acting on mAChRs, triggered a negative effect on NOS activity, PGE(2), and MMP-3 production.
Negative_regulation (effect) of Gene_expression (production) of MMP-3
1) Confidence 0.44 Published 2009 Journal J Endod Section Abstract Doc Link 19345799 Disease Relevance 0.29 Pain Relevance 0.34
We demonstrated that MMP 1 and 9 expression is increased, and MMP 3 expression is decreased in degenerated LHB compared with healthy controls.
Negative_regulation (decreased) of Gene_expression (expression) of MMP 3 associated with metalloproteinase
2) Confidence 0.24 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2998463 Disease Relevance 0.77 Pain Relevance 0.25
MMP 3 expression was significantly decreased compared to group I (p = 0.012), while no significant difference in MMP 3 expression was seen in Groups II-IV.
Negative_regulation (decreased) of Gene_expression (expression) of MMP 3 associated with metalloproteinase
3) Confidence 0.24 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2998463 Disease Relevance 0.40 Pain Relevance 0.53
Compared with controls, both MMP 1 and 9 expression was significantly increased whereas MMP 3 expression was significantly decreased (p = 0.027 and 0.035, respectively).
Negative_regulation (decreased) of Gene_expression (expression) of MMP 3 associated with metalloproteinase
4) Confidence 0.24 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2998463 Disease Relevance 0.26 Pain Relevance 0.35
[Effects of infliximab and etanercept, two types of anti-tumor necrosis factor-alpha inhibitor on serum level of matrix metalloproteinase 3 expression in patients with ankylosing spondylitis].
Negative_regulation (level) of Gene_expression (expression) of matrix metalloproteinase 3 associated with spinal inflammation, necrosis, infliximab, cancer, metalloproteinase and etanercept
5) Confidence 0.20 Published 2006 Journal Zhonghua Yi Xue Za Zhi Section Title Doc Link 17156669 Disease Relevance 0.30 Pain Relevance 0.48
Increased MMP 1 and 9 expression, and decreased MMP 3 expression are found in LHB degeneration.
Negative_regulation (decreased) of Gene_expression (expression) of MMP 3 associated with metalloproteinase
6) Confidence 0.18 Published 2010 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2998463 Disease Relevance 0.30 Pain Relevance 0.43
LHB degeneration is associated with increased MMP 1 and 9 expression and decreased MMP 3 expression.
Negative_regulation (decreased) of Gene_expression (expression) of MMP 3 associated with metalloproteinase
7) Confidence 0.18 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2998463 Disease Relevance 0.58 Pain Relevance 0.26
MMP 3 expression was significantly decreased compared to the control group (p = 0.043) but there was no significant difference compared to groups II and III.
Negative_regulation (decreased) of Gene_expression (expression) of MMP 3 associated with metalloproteinase
8) Confidence 0.18 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2998463 Disease Relevance 0.29 Pain Relevance 0.57
We demonstrated that MMP 1 and 9 expression is increased, and MMP 3 expression is decreased in degenerated LHB compared with healthy controls.
Negative_regulation (decreased) of Gene_expression (expression) of MMP 3 associated with metalloproteinase
9) Confidence 0.18 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2998463 Disease Relevance 0.30 Pain Relevance 0.53
MMP 1 and 9 expression was significantly higher in the presence of rotator cuff tears than in controls whereas MMP 3 expression was significantly decreased.
Negative_regulation (decreased) of Gene_expression (expression) of MMP 3 in tears associated with metalloproteinase and rotator cuff tears
10) Confidence 0.18 Published 2010 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2998463 Disease Relevance 0.51 Pain Relevance 0.53
However, multiple authors have confirmed our findings, of increased MMP 1 and 9 as well as decreased MMP 3 expression in degenerated Achilles tendons [26-28].
Negative_regulation (decreased) of Gene_expression (expression) of MMP 3 in tendons associated with metalloproteinase
11) Confidence 0.18 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2998463 Disease Relevance 0.35 Pain Relevance 0.49
g/ml, there was a significant inhibition of proMMP-3 production.
Negative_regulation (inhibition) of Gene_expression (production) of proMMP-3
12) Confidence 0.11 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.19 Pain Relevance 0.15
In our report, we found that MMP-3 mRNA expression and MMP (-1, -2, -3, -7, and -9) activities were decreased, while a slight downregulation of MMP-13 mRNA expression or activity was observed.
Negative_regulation (decreased) of Gene_expression (expression) of MMP-3 mRNA associated with metalloproteinase
13) Confidence 0.08 Published 2010 Journal PPAR Research Section Body Doc Link PMC2957135 Disease Relevance 0.08 Pain Relevance 0.47
Anti-FGF8 antibody suppressed the production of proMMP-3 and PGE2 from cultured chondrocytes.
Negative_regulation (suppressed) of Gene_expression (production) of proMMP-3 in chondrocytes
14) Confidence 0.08 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 1.03 Pain Relevance 0.53
It also blocked the IL-1-induced expression of matrix-specific proteases such as MMP-3, MMP-9, MMP-10, MMP-12, and ADAMTS-1.
Negative_regulation (blocked) of Gene_expression (expression) of MMP-3
15) Confidence 0.08 Published 2006 Journal Arthritis Res Ther Section Abstract Doc Link PMC1794517 Disease Relevance 0.26 Pain Relevance 0.18

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