INT140525

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Context Info
Confidence 0.62
First Reported 2007
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.59
Pain Relevance 2.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ptn) endoplasmic reticulum (Ptn)
Anatomy Link Frequency
DRG 2
Ptn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 5 99.68 Very High Very High Very High
Neuropathic pain 6 99.56 Very High Very High Very High
Eae 10 98.96 Very High Very High Very High
Morphine 5 98.24 Very High Very High Very High
cytokine 4 98.04 Very High Very High Very High
Pain 2 98.04 Very High Very High Very High
Sciatic nerve 2 96.52 Very High Very High Very High
Hippocampus 4 93.24 High High
GABAergic 4 92.48 High High
antagonist 28 86.56 High High
Disease Link Frequency Relevance Heat
Sprains And Strains 12 99.64 Very High Very High Very High
Neuropathic Pain 8 99.56 Very High Very High Very High
Injury 10 98.96 Very High Very High Very High
Nervous System Injury 4 91.88 High High
Gliosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Different pattern of pleiotrophin and midkine expression in neuropathic pain: correlation between changes in pleiotrophin gene expression and rat strain differences in neuropathic pain.
Regulation (changes) of Gene_expression (expression) of pleiotrophin gene associated with neuropathic pain, sprains and strains and cytokine
1) Confidence 0.62 Published 2008 Journal Growth Factors Section Title Doc Link 18365878 Disease Relevance 1.24 Pain Relevance 0.75
Real time RT-PCR revealed minimal changes in PTN/MK gene expression in the spinal cord after CCI despite the strain considered, but marked changes were detected in DRG.
Regulation (changes) of Gene_expression (expression) of PTN in DRG associated with eae, sprains and strains and spinal cord
2) Confidence 0.45 Published 2008 Journal Growth Factors Section Abstract Doc Link 18365878 Disease Relevance 1.36 Pain Relevance 0.64
Pleiotrophin gene expression was not altered by any treatment; however midkine mRNA levels were increased after chronic treatment with morphine.
Neg (not) Regulation (altered) of Gene_expression (expression) of Pleiotrophin gene associated with morphine
3) Confidence 0.38 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17157293 Disease Relevance 0 Pain Relevance 0.92
Second, across the cycle of posture-related corrections, bicuculline affected PTN responses not uniformly but in a strong phase-dependent manner, being maximal in the period of higher PTN activity.
Regulation (affected) of Gene_expression (responses) of PTN
4) Confidence 0.13 Published 2007 Journal The European Journal of Neuroscience Section Body Doc Link PMC2777253 Disease Relevance 0 Pain Relevance 0.18

General Comments

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