INT140542

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Context Info
Confidence 0.65
First Reported 2006
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 13.58
Pain Relevance 3.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SSTR2) cell-cell signaling (SSTR2) cytoplasm (SSTR2)
signal transducer activity (SSTR2)
Anatomy Link Frequency
blood vessels 2
liver 1
arms 1
SSTR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 1391 100.00 Very High Very High Very High
imagery 89 99.84 Very High Very High Very High
opioid receptor 25 99.44 Very High Very High Very High
agonist 59 89.16 High High
Enkephalin 3 81.52 Quite High
Opioid 16 76.88 Quite High
Dopamine 77 75.28 Quite High
abdominal pain 2 68.48 Quite High
palliative 15 66.96 Quite High
cva 4 27.12 Quite Low
Disease Link Frequency Relevance Heat
Glucagonoma 78 99.98 Very High Very High Very High
Adenocarcinoma 39 99.98 Very High Very High Very High
Gastrinoma 52 99.64 Very High Very High Very High
Insulinoma 156 99.60 Very High Very High Very High
Cancer 1255 99.56 Very High Very High Very High
Hypoglycemia 65 99.42 Very High Very High Very High
Somatostatinoma 52 98.88 Very High Very High Very High
Metastasis 200 98.56 Very High Very High Very High
Carcinoid 286 97.76 Very High Very High Very High
Pancreatic Cancer 52 96.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Somatostatin receptor scintigraphy (SRS, OctreoScan®), (e.g. 111In-pentetreotide) can visualise in vivo tumours and metastases that express the somatostatin receptor subtypes 2, 3 or 5 [16] except for metastatic insulinomas, of which only 50% express SSTR 2.
Gene_expression (express) of SSTR 2 associated with cancer, somatostatin, insulinoma and metastasis
1) Confidence 0.65 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 0.88 Pain Relevance 0.57
The loss of the SSTR 2 expression in some human adenocarcinomas seems to be responsible for loosing the regulation of cell proliferation [8].
Gene_expression (expression) of SSTR 2 associated with adenocarcinoma
2) Confidence 0.65 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 0.95 Pain Relevance 0.21
In conclusion, in many cases authors did not stratify patients in treatment arms, according to the histological presence of the SSTR 2 receptor or its clinical expression.
Gene_expression (expression) of SSTR 2 receptor in arms
3) Confidence 0.65 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 0.66 Pain Relevance 0.16
These effects may be attributable to SSTR 2 which is the most frequently expressed subtype and/or SSTR 5, 1 and 3 which are also expressed [90,91].
Gene_expression (expressed) of SSTR 2
4) Confidence 0.65 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 1.01 Pain Relevance 0.14
A complete clinical remission with regression of the metastatic lesions in the liver after one year of treatment was observed in a patient affected by metastatic insulinoma with severe hypoglycaemia treated with octreotide LAR expressing at immunohistochemical analysis of tissue specimens a strong membrane immunoreactivity for SSTR 2 in both the primary nodule and the metastases [85].
Gene_expression (expressing) of SSTR 2 in liver associated with hypoglycemia, insulinoma and metastasis
5) Confidence 0.65 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 0.98 Pain Relevance 0.11
SSTR 2 is the most frequently expressed [34].
Gene_expression (expressed) of SSTR 2
6) Confidence 0.65 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 1.21 Pain Relevance 0.14
It was observed that standard endothelial cells do not express the SSTR 2 that is present on the contrary, when they proliferate in order to form blood vessels.
Neg (not) Gene_expression (express) of SSTR 2 in blood vessels
7) Confidence 0.65 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 0.33 Pain Relevance 0.10
Pancreatic insulinomas had heterogeneous SSTRs expression while 100% of somatostatinomas expressed SSTR 5 and 100% gastrinomas and glucagonomas expressed SSTR 2 [11].
Gene_expression (expressed) of SSTR 2 associated with glucagonoma, gastrinoma, insulinoma and somatostatinoma
8) Confidence 0.56 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 0.74 Pain Relevance 0.35
It was observed that standard endothelial cells do not express the SSTR 2 that is present on the contrary, when they proliferate in order to form blood vessels.
Gene_expression (present) of SSTR 2 in blood vessels
9) Confidence 0.56 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 0.33 Pain Relevance 0.10
Novel strategies based on SSTR 2 receptor gene transfer to target tumor growth and angiogenesis might offer new prospectives of therapeutic interest mainly to treat unresectable tumours.
Gene_expression (transfer) of SSTR 2 receptor gene associated with cancer
10) Confidence 0.50 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 0.57 Pain Relevance 0.20
Takei et al. (2007) determined the expression of SSTR2 and SSTR5 by IHC and compared this with the results of octreotide suppression testing before surgery to define whether IHC of SSTR could be associated with the preoperative response to octreotide.
Spec (determined) Gene_expression (expression) of SSTR2
11) Confidence 0.45 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2522328 Disease Relevance 0.90 Pain Relevance 0.10
Several study conducted on pancreatic adenocarcinoma animal models demonstrated that intratumoural SSTR 2 gene transfer (using polyethylenimine synthetic vector) inhibited intratumoural production of somatostatin that was critical for the SSTR 2 antitumoral effect.
Gene_expression (transfer) of SSTR 2 associated with adenocarcinoma and somatostatin
12) Confidence 0.44 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 0.86 Pain Relevance 0.16
This review provides an update on the use of somatostatin analogues in the management of GEP NETs and discusses novel clinical strategies based on SSTR 2 gene transfer therapy.



Gene_expression (transfer) of SSTR 2 associated with somatostatin
13) Confidence 0.44 Published 2010 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC2845555 Disease Relevance 0.26 Pain Relevance 0.44
Buscail et al initially demonstrated that in human pancreatic adenocarcinoma SSTR 2 expression was specifically los[8].
Gene_expression (expression) of SSTR 2 associated with adenocarcinoma
14) Confidence 0.44 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 0.96 Pain Relevance 0.14
Immunohistochemically, both components were positive for synaptophysin and somatostatin receptor 2 with the latter one being consistent with the positive octreotid scan.
Gene_expression (positive) of somatostatin receptor 2 associated with somatostatin
15) Confidence 0.36 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2997098 Disease Relevance 1.19 Pain Relevance 0.17
The immunohistochemical expression of somatostatin receptor 2 (SSTR2) and the quantitative mRNA analysis of SSTR2 and SSTR5 were assessed in 12 tumours.
Gene_expression (expression) of SSTR2 associated with cancer and somatostatin
16) Confidence 0.32 Published 2006 Journal Endocr. Relat. Cancer Section Abstract Doc Link 17158766 Disease Relevance 0.83 Pain Relevance 0.19
The immunohistochemical expression of somatostatin receptor 2 (SSTR2) and the quantitative mRNA analysis of SSTR2 and SSTR5 were assessed in 12 tumours.
Gene_expression (expression) of SSTR2 associated with cancer and somatostatin
17) Confidence 0.25 Published 2006 Journal Endocr. Relat. Cancer Section Abstract Doc Link 17158766 Disease Relevance 0.91 Pain Relevance 0.20
HEK293 cells have been reported to possess mRNA for a number of receptors that were not found to be expressed at statistically significant levels in our study: 5HT1D, 5HT6, 5HT7, ADRA2(a-c), ADRAB2, AGTR1, BDKRB2, DRD2, GPR1, GPR161, GRM4, P2YR2 and SSTR2 [17,26,46-50].
Gene_expression (expressed) of SSTR2
18) Confidence 0.17 Published 2011 Journal BMC Genomics Section Body Doc Link PMC3024950 Disease Relevance 0 Pain Relevance 0
An example of an instance of the Internalization concept is provided by confocal microscopy studies carried out on co-expressed sst2A somatostatin receptor and ?
Gene_expression (expressed) of sst2A somatostatin receptor associated with somatostatin
19) Confidence 0.02 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC1904246 Disease Relevance 0 Pain Relevance 0.46

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