INT140547

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Context Info
Confidence 0.02
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.33
Pain Relevance 2.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PSMB10) nucleoplasm (PSMB10) peptidase activity (PSMB10)
small molecule metabolic process (PSMB10) nucleus (PSMB10) cellular nitrogen compound metabolic process (PSMB10)
Anatomy Link Frequency
embryonic kidney 1
PSMB10 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 20 99.84 Very High Very High Very High
Opioid 8 99.52 Very High Very High Very High
MU agonist 2 99.44 Very High Very High Very High
tolerance 8 99.24 Very High Very High Very High
agonist 18 98.78 Very High Very High Very High
Enkephalin 18 84.52 Quite High
Taxol 4 48.16 Quite Low
Inflammation 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 94 99.48 Very High Very High Very High
Cancer 114 99.28 Very High Very High Very High
Breast Cancer 136 98.96 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 34 94.72 High High
Stress 2 92.00 High High
Recurrence 4 91.12 High High
Death 10 91.00 High High
Disease 18 83.44 Quite High
Disease Progression 4 80.72 Quite High
Fatigue 2 71.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of agonist-induced down-regulation of the delta-opioid receptor with a proteasome inhibitor attenuates opioid tolerance in human embryonic kidney 293 cells.
Negative_regulation (inhibitor) of proteasome in embryonic kidney associated with tolerance, agonist, opioid receptor and opioid
1) Confidence 0.02 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 17159161 Disease Relevance 0 Pain Relevance 1.35
The results of this study demonstrated that inhibition of agonist-induced down regulation with a proteasome inhibitor attenuated opioid tolerance in a cellular model, and suggest that coadministration of a proteasome inhibitor with chronic opioid agonist treatment may be useful for limiting opioid tolerance in vivo.
Negative_regulation (inhibitor) of proteasome associated with mu agonist, tolerance, agonist and opioid
2) Confidence 0.02 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17159161 Disease Relevance 0 Pain Relevance 1.57
Bortezomib is also a potent inhibitor of the 26S proteasome, with broad anti-tumour activity (Table 1).
Negative_regulation (inhibitor) of proteasome associated with cancer
3) Confidence 0.00 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 1.08 Pain Relevance 0
Thus, combined treatment with HDACi and proteasome inhibitors potentiates apoptosis in breast cancer cells, representing a novel potential therapeutic strategy in breast cancer [20].
Negative_regulation (inhibitors) of proteasome associated with breast cancer and apoptosis
4) Confidence 0.00 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 1.25 Pain Relevance 0

General Comments

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