INT14060

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Context Info
Confidence 0.53
First Reported 1983
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 3.53
Pain Relevance 3.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Insr) endosome (Insr) plasma membrane (Insr)
nucleus (Insr)
Anatomy Link Frequency
sciatic nerve 4
dorsal 3
N-IL 2
ventral 1
Insr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
mu opioid receptor 12 100.00 Very High Very High Very High
antagonist 7 99.60 Very High Very High Very High
narcan 3 99.14 Very High Very High Very High
agonist 4 98.96 Very High Very High Very High
Hippocampus 10 98.88 Very High Very High Very High
Nerve growth factor 8 98.16 Very High Very High Very High
Sciatic nerve 4 97.12 Very High Very High Very High
Morphine 2 96.74 Very High Very High Very High
dexamethasone 3 94.56 High High
unmyelinated 4 83.20 Quite High
Disease Link Frequency Relevance Heat
Stress 10 98.76 Very High Very High Very High
Diabetes Mellitus 18 97.32 Very High Very High Very High
Hyperalgesia 2 80.80 Quite High
Nociception 10 77.76 Quite High
Neuropathic Pain 6 76.80 Quite High
Opiate Addiction 1 76.28 Quite High
Ganglion Cysts 2 60.36 Quite High
Drug Dependence 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acute morphine administration (10 mg/kg) did not affect levels of ir-beta EP in any tissue, baseline or post-stress; however, naloxone (10 mg/kg) consistently and significantly prevented the reduction in N-IL ir-beta EP otherwise found following prolonged stress.
Negative_regulation (prevented) of Negative_regulation (reduction) of N-IL ir-beta EP in N-IL associated with stress, narcan and morphine
1) Confidence 0.53 Published 1983 Journal Neuroendocrinology Section Abstract Doc Link 6300719 Disease Relevance 0.71 Pain Relevance 0.57
Treatment with a D(4) R antagonist (L745,870, 1mg/kg) blocked downregulation of MOR IR, showing that the D(4) R agonist effects observed were specific.
Negative_regulation (blocked) of Negative_regulation (downregulation) of IR associated with antagonist, agonist and mu opioid receptor
2) Confidence 0.43 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17366605 Disease Relevance 0.08 Pain Relevance 1.14
Osmopump delivery prevented the decline of NGFR-TrkA, insulin receptor (P < 0.05), and IGF-IR (P < 0.005) expressions in DRGs and improved NGF content (P < 0.05) in sciatic nerve.
Negative_regulation (prevented) of Negative_regulation (decline) of insulin receptor in sciatic nerve associated with nerve growth factor and sciatic nerve
3) Confidence 0.39 Published 2006 Journal Diabetes Section Abstract Doc Link 17130507 Disease Relevance 1.37 Pain Relevance 0.46
Osmopump delivery prevented the decline of NGFR-TrkA, insulin receptor (P < 0.05), and IGF-IR (P < 0.005) expressions in DRGs and improved NGF content (P < 0.05) in sciatic nerve.
Negative_regulation (prevented) of Negative_regulation (decline) of IGF-IR in sciatic nerve associated with nerve growth factor and sciatic nerve
4) Confidence 0.39 Published 2006 Journal Diabetes Section Abstract Doc Link 17130507 Disease Relevance 1.37 Pain Relevance 0.46
Daily DGG pretreatment almost completely abolished WDS at control threshold intensities, and significantly inhibited stimulation-induced decrease of DYN-IR in both dorsal and ventral hippocampus.
Negative_regulation (inhibited) of Negative_regulation (decrease) of DYN-IR in dorsal associated with hippocampus
5) Confidence 0.27 Published 1991 Journal Brain Res. Section Abstract Doc Link 1685342 Disease Relevance 0 Pain Relevance 0.40
Daily DGG pretreatment almost completely abolished WDS at control threshold intensities, and significantly inhibited stimulation-induced decrease of DYN-IR in both dorsal and ventral hippocampus.
Negative_regulation (inhibited) of in ventral Negative_regulation (decrease) of DYN-IR in dorsal associated with hippocampus
6) Confidence 0.09 Published 1991 Journal Brain Res. Section Abstract Doc Link 1685342 Disease Relevance 0 Pain Relevance 0.40

General Comments

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