INT140610

Context Info Confidence 0.05 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.74 Pain Relevance 0.08

nucleoplasm (ATF4) DNA binding (ATF4) microtubule organizing center (ATF4) cytoplasm (ATF4) nucleus (ATF4) cytoskeleton (ATF4)

SNAR-I (Homo sapiens) ATF4 (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 1 77.80

Disease Link Frequency Relevance Heat Cancer 4 97.32 Stomach Cancer 2 92.12 Hypoxia 1 86.12 INFLAMMATION 1 77.56 Apoptosis 5 76.20

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Both the ATF4 and ATF6 pathways were activated by celecoxib, and suppression of ATF4 and ATF6 mRNA expression by small interfering RNA (siRNA) inhibited the celecoxib-dependent up-regulation of ORP150.

small interfering RNA Negative_regulation (suppression) of Gene_expression (expression) of ATF4

1) Confidence 0.05 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17167033 Disease Relevance 0.74 Pain Relevance 0.08

General Comments

This test has worked.