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Context Info
Confidence 0.58
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.73
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ATF4) DNA binding (ATF4) microtubule organizing center (ATF4)
cytoplasm (ATF4) nucleus (ATF4) cytoskeleton (ATF4)
Anatomy Link Frequency
reticulum 1
ATF4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 10 93.80 High High
aspirin 5 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 3 97.44 Very High Very High Very High
Cancer 16 96.72 Very High Very High Very High
Stomach Cancer 5 92.44 High High
Hypoxia 1 85.52 High High
Adhesions 4 79.12 Quite High
Apoptosis 20 77.76 Quite High
INFLAMMATION 8 76.96 Quite High
Colon Cancer 40 50.00 Quite Low
Hypersensitivity 5 5.00 Very Low Very Low Very Low
Leukemia 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The celecoxib-mediated up-regulation of S100P was suppressed by the transfection of cells with small interfering RNA for activating transcription factor 4 (ATF4), a transcription factor involved in the endoplasmic reticulum stress response.
Transcription (transcription) of ATF4 in reticulum associated with stress
1) Confidence 0.58 Published 2009 Journal J. Biol. Chem. Section Abstract Doc Link 19073601 Disease Relevance 0.79 Pain Relevance 0.32
Both the ATF4 and ATF6 pathways were activated by celecoxib, and suppression of ATF4 and ATF6 mRNA expression by small interfering RNA (siRNA) inhibited the celecoxib-dependent up-regulation of ORP150.
Transcription (expression) of ATF4
2) Confidence 0.49 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17167033 Disease Relevance 0.73 Pain Relevance 0.08
Among these were transcription factors such as activating transcription factor 4 (ATF4) and early growth response 1 (EGR1) (Table 2).
Transcription (transcription) of ATF4
3) Confidence 0.37 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.21 Pain Relevance 0

General Comments

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