INT140621

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Context Info
Confidence 0.73
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 11
Disease Relevance 2.60
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Hcrt) cytoplasm (Hcrt)
Anatomy Link Frequency
neurons 4
pons 2
Hcrt (Mus musculus)
Pain Link Frequency Relevance Heat
Locus ceruleus 82 99.78 Very High Very High Very High
Opioid 2 99.64 Very High Very High Very High
Dynorphin 14 99.00 Very High Very High Very High
gABA 80 97.44 Very High Very High Very High
antagonist 17 95.16 Very High Very High Very High
Endocannabinoid 35 92.64 High High
Neuropeptide 31 88.00 High High
Cannabinoid 33 81.44 Quite High
medulla 13 78.92 Quite High
Glutamate 2 74.88 Quite High
Disease Link Frequency Relevance Heat
Sleep Disorders 476 99.08 Very High Very High Very High
Targeted Disruption 250 94.32 High High
Hypoxia 4 92.80 High High
Overdose 20 65.40 Quite High
Hyperglycemia 4 62.40 Quite High
Congenital Anomalies 4 60.64 Quite High
Vibrio Infection 10 57.84 Quite High
Apoptosis 16 47.36 Quite Low
Death 40 44.36 Quite Low
Depression 1 27.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As the protein is co-localized with HCRT, IGFBP3 could have been an autoantigen involved in the hypothesized autoimmune attack directed against the HCRT neurons.
Localization (localized) of HCRT in neurons
1) Confidence 0.73 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.38 Pain Relevance 0
All neurons showing colocalization of IGFBP3 and HCRT appeared to have a reduced hypocretin signal.
Localization (colocalization) of HCRT in neurons
2) Confidence 0.73 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.22 Pain Relevance 0.03
As hypocretin release is highest at this time of the day (equivalent to the evening in humans), higher IGFBP3 levels may affect hypocretin transmission only at times of highest demand, through the reduction of releasable peptide stores in terminals.
Localization (release) of hypocretin
3) Confidence 0.73 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.42 Pain Relevance 0.04
Similarly, the orexigenic effect of orexin A/hypocretin 1 is also blocked by rimonabant administration [23].
Localization (hypocretin) of orexin A
4) Confidence 0.73 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258435 Disease Relevance 0 Pain Relevance 0.53
To confirm in mice, we examined another region such as the locus coeruleus where the hypocretin-1 receptor is present [26], [27], and did not find hypocretin-2 receptor immunoreactive neurons.
Localization (find) of hypocretin in neurons associated with locus ceruleus
5) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.29 Pain Relevance 0.13
To confirm in mice, we examined another region such as the locus coeruleus where the hypocretin-1 receptor is present [26], [27], and did not find hypocretin-2 receptor immunoreactive neurons.
Localization (find) of hypocretin in neurons associated with locus ceruleus
6) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.23 Pain Relevance 0.13
This is the first study to find an additive effect of deletion of both HCRT and HCRT receptor bearing neurons in the pons.
Localization (deletion) of HCRT in pons
7) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.36 Pain Relevance 0.17
This is the first study to find an additive effect of deletion of both HCRT and HCRT receptor bearing neurons in the pons.
Localization (deletion) of HCRT receptor in pons
8) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.36 Pain Relevance 0.19
In these both hypocretin and MCH were visualized using the secondary antibody conjugated to the alexa 647 (Jackson Immunoresearch Laboratories, West grove, PA).
Localization (visualized) of hypocretin
9) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.12 Pain Relevance 0
Therefore we studied Hcrt KO mice and found that Igfbp3 expression was similar to that of WT mice (Fig. 1) indicating that loss of HCRT peptide itself did not induce changes in Igfbp3 expression.
Localization (loss) of HCRT
10) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.21 Pain Relevance 0
The hypocretin peptide is colocalized with an opioid peptide, dynorphin.
Localization (colocalized) of hypocretin peptide associated with dynorphin and opioid
11) Confidence 0.39 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 17167093 Disease Relevance 0 Pain Relevance 0.42

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