INT140637

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Context Info
Confidence 0.40
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 9.48
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (IFI27) molecular_function (IFI27)
Anatomy Link Frequency
T cells 1
IFI27 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 52 84.68 Quite High
Inflammation 77 82.96 Quite High
cINOD 25 72.88 Quite High
cytokine 39 56.68 Quite High
rheumatoid arthritis 6 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
Crohn's disease 5 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
Chronic pancreatitis 3 5.00 Very Low Very Low Very Low
Paracetamol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 418 100.00 Very High Very High Very High
Takayasu Arteritis 100 99.64 Very High Very High Very High
Systemic Lupus Erythematosus 8 98.08 Very High Very High Very High
Carcinoma 15 97.92 Very High Very High Very High
Idiopathic Thrombocytopenic Purpura 8 97.76 Very High Very High Very High
Apoptosis 252 97.68 Very High Very High Very High
Breast Cancer 132 97.52 Very High Very High Very High
Endometrial Cancer 17 97.20 Very High Very High Very High
Autoimmune Disease 65 95.72 Very High Very High Very High
Infection 3 94.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
on both the expression and activity of cyclin-dependent kinase inhibitors [CDKI] such as p21 and p27.
Negative_regulation (inhibitors) of p27
1) Confidence 0.40 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1208869 Disease Relevance 0.51 Pain Relevance 0
Curiously, the remnants of p27 staining were confined to the nuclear envelope (arrows, Fig. 9, C and 9F; see also Fig. 10A), suggesting a degradation of p27 in the nuclear core, and/or a defect of p27 synthesis/transport.
Negative_regulation (defect) of p27
2) Confidence 0.40 Published 2001 Journal BMC Clin Pathol Section Body Doc Link PMC59662 Disease Relevance 0.07 Pain Relevance 0
In contrast, interferon gamma (IFN-G) and interferon-induced genes (G1P2, IFI44, IFIT1, IFIT2 and IFI27) were down-regulated in many TA patients, which distinguish TA from SLE and ITP, as these genes are up-regulated in the latter autoimmune diseases.
Negative_regulation (regulated) of IFI27 associated with takayasu arteritis, autoimmune disease, idiopathic thrombocytopenic purpura and systemic lupus erythematosus
3) Confidence 0.29 Published 2010 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2993541 Disease Relevance 1.83 Pain Relevance 0.17
In contrast, interferon gamma (IFN-G) and interferon-induced genes (G1P2, IFI44, IFIT1, IFIT2 and IFI27) were down-regulated in many TA patients, which distinguish TA from SLE and ITP, as these genes are up-regulated in the latter autoimmune diseases.
Negative_regulation (down) of IFI27 associated with takayasu arteritis, autoimmune disease, idiopathic thrombocytopenic purpura and systemic lupus erythematosus
4) Confidence 0.29 Published 2010 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2993541 Disease Relevance 1.82 Pain Relevance 0.17
The tumor suppressor p27 was not down-regulated in the present case.
Negative_regulation (down) of p27 associated with cancer
5) Confidence 0.25 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC1947947 Disease Relevance 1.39 Pain Relevance 0
These kinases are activated by cyclins D and E and inactivated by CDK inhibitors (CDKIs) including: p27, p16, and p21[44].
Negative_regulation (inhibitors) of p27
6) Confidence 0.23 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2913917 Disease Relevance 0.83 Pain Relevance 0
Cadmium may activate oncogenes such as c-myc, mdm2, and cellular tumor antigen p53; inhibit tumor suppressor genes such as wild-type p53 and p27; and consequently promote the proliferation of initiated cells (Fang et al. 2002).
Negative_regulation (inhibit) of p27 associated with cancer
7) Confidence 0.21 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1332665 Disease Relevance 0.57 Pain Relevance 0
Concerning cell cycle, PKB is able to phosphorylate cdk inhibitors, such as p21 and p27, leading to PCNA activation [168, 169].
Negative_regulation (inhibitors) of p27
8) Confidence 0.12 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.80 Pain Relevance 0.13
BRCA1 could be characterized as having a basal phenotype, ER-negative and HER2-negative, with up-regulation of cyclin A and caspase 3, but downregulation of cyclin D1 and D3, CDKIs (p16, p21, p27), and BCL2, the opposite phenotype from most BRCA2 carcinomas.
Negative_regulation (downregulation) of p27 associated with carcinoma
9) Confidence 0.11 Published 2006 Journal Proteome Sci Section Body Doc Link PMC1456950 Disease Relevance 1.13 Pain Relevance 0.21
Consequently, the down-regulation of p27 was reported to be associated with trastuzumab resistance in breast cancer cell lines (Nahta et al 2004).
Negative_regulation (regulation) of p27 associated with breast cancer
10) Confidence 0.05 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721347 Disease Relevance 0.33 Pain Relevance 0
Interestingly, few dietary compounds listed in this review also have effect on APC, cdk inhibitors p21(Waf1/Cip1) and p27.
Negative_regulation (inhibitors) of p27
11) Confidence 0.05 Published 2006 Journal Curr Cancer Drug Targets Section Abstract Doc Link 17168675 Disease Relevance 0.19 Pain Relevance 0
Interestingly, levels of key cell cycle inhibitors p21, p27, and p53 did not significantly differ in control and Gal-4 co-cultured activated T cells (not shown).
Negative_regulation (inhibitors) of p27 in T cells
12) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0 Pain Relevance 0

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