INT140645

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Context Info
Confidence 0.78
First Reported 2006
Last Reported 2008
Negated 2
Speculated 1
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 4.48
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DSG3) cell adhesion (DSG3) plasma membrane (DSG3)
Anatomy Link Frequency
pancreas 1
BxPC-3 1
T cells 1
DSG3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 45 95.52 Very High Very High Very High
Pain 5 75.60 Quite High
corticosteroid 44 55.24 Quite High
Inflammation 20 32.12 Quite Low
agonist 4 29.44 Quite Low
methotrexate 4 22.12 Low Low
Disease Link Frequency Relevance Heat
Pemphigoid 148 99.84 Very High Very High Very High
Pancreatic Cancer 114 99.16 Very High Very High Very High
Bullous Skin Disease 14 97.28 Very High Very High Very High
Pancreatitis 51 95.52 Very High Very High Very High
Autoimmune Disease 16 93.88 High High
Disease 50 93.08 High High
Adenocarcinoma 42 90.20 High High
Hepatocellular Cancer 2 83.28 Quite High
Lichen 2 75.00 Quite High
Malignant Neoplastic Disease 22 72.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The EC1/EC2 Dsg349–60REWVKFAKPCRE peptide was synthesized using standard Fmoc (N-(9-fluorenyl)methoxycarbonyl) solid phase peptide synthesis.
Gene_expression (synthesized) of Dsg349
1) Confidence 0.78 Published 2006 Journal J Transl Med Section Body Doc Link PMC1630706 Disease Relevance 0.43 Pain Relevance 0
Following a series of in vitro and animal experiments [32-34], our studies have progressively focused on the Dsg349–60REWVKFAKPCRE peptide sequence that 1) is uniquely expressed in Dsg3 and, consequently, cannot induce/provoke collateral secondary autoimmune cross-reactions [22-34]; 2) is hosted in a Dsg3 domain involved in the intramolecular epitope spreading characterizing the progression of PV from mucous to muco-cutaneous stage [35]; 3) does not produce pathogenic antibodies [33].
Gene_expression (expressed) of Dsg3 associated with pemphigoid
2) Confidence 0.78 Published 2006 Journal J Transl Med Section Body Doc Link PMC1630706 Disease Relevance 0.58 Pain Relevance 0.03
Since the ability of the antibodies used to detect Dsg3 by immunohistochemistry was verified using sections of normal human skin as a positive control (data not shown), these findings indicate that Dsg3 is not expressed at detectable levels in human pancreas.
Neg (not) Gene_expression (expressed) of Dsg3 in pancreas
3) Confidence 0.71 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.34 Pain Relevance 0.06
As regards PV, the HLA selective presentation of DSG3 peptides in PV has been thoroughly analyzed, starting from the premise that peptide presentation to T cells may be important in the initiation or progression of autoimmune diseases.
Gene_expression (peptides) of DSG3 in T cells associated with autoimmune disease and pemphigoid
4) Confidence 0.59 Published 2006 Journal J Transl Med Section Body Doc Link PMC1630706 Disease Relevance 0.59 Pain Relevance 0
Immunoblotting using normal human epidermal extract detected the 210-kD envoplakin, 190-kD periplakin and 130-kD Dsg3.
Gene_expression (detected) of Dsg3
5) Confidence 0.58 Published 2006 Journal J. Dermatol. Section Abstract Doc Link 17169086 Disease Relevance 0.71 Pain Relevance 0.08
The expression of Dsg1, Dsg2, and Dsg3 in pancreatic tissues was examined by immunohistochemistry and their expression in two pancreatic cancer cell lines, BxPC-3 and Panc-1, was determined by western blot analysis.
Spec (examined) Gene_expression (expression) of Dsg3 in BxPC-3 associated with pancreatic cancer
6) Confidence 0.55 Published 2008 Journal BMC Cancer Section Abstract Doc Link PMC2628383 Disease Relevance 0.48 Pain Relevance 0.06
In contrast, Dsg3 was not detected in any of the pancreatic tissues (data not shown).
Neg (not) Gene_expression (detected) of Dsg3
7) Confidence 0.55 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.71 Pain Relevance 0.27
Following a series of in vitro and animal experiments [32-34], our studies have progressively focused on the Dsg349–60REWVKFAKPCRE peptide sequence that 1) is uniquely expressed in Dsg3 and, consequently, cannot induce/provoke collateral secondary autoimmune cross-reactions [22-34]; 2) is hosted in a Dsg3 domain involved in the intramolecular epitope spreading characterizing the progression of PV from mucous to muco-cutaneous stage [35]; 3) does not produce pathogenic antibodies [33].
Gene_expression (expressed) of Dsg349 associated with pemphigoid
8) Confidence 0.53 Published 2006 Journal J Transl Med Section Body Doc Link PMC1630706 Disease Relevance 0.65 Pain Relevance 0.03

General Comments

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